DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sac1 and synj2

DIOPT Version :9

Sequence 1:	NP_001189016.1	Gene:	Sac1 / 38137	FlyBaseID:	FBgn0283500	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001135511.1	Gene:	synj2 / 100216051	XenbaseID:	XB-GENE-980087	Length:	1553	Species:	Xenopus tropicalis

Alignment Length:	554	Identity:	168/554 - (30%)
Similarity:	254/554 - (45%)	Gaps:	105/554 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 APQSFIIEPNGGDELLVIGRHDKVTRVQPASGGLVANLRPTRR------------ICGVLGTIHL 70
            ||.|.::|....::.|:.            ..|.||.|.|..|            ..|.||.:.|
Frog    16 APYSVLLESRNREDCLLF------------ESGTVATLTPDEREVIRGQYERLQDAYGCLGELCL 68

  Fly    71 LS----CDYLLVATHRLFVGVLNGAVVWRLAGYDIIPYIPNSFQRKENENYLRLLRQTLDTKFFY 131
            .|    .::|::.:....||.:..|.|:::...|   :.|...:.||.|. :..||:.|::..||
Frog    69 KSGNIPLNFLILVSGCSSVGRILDAEVYKITATD---FCPLQEETKEEER-VTALRKILNSGMFY 129

  Fly   132 FSY-----RYDLTNSLQRQREVAQSRPEVSGLLQRAEQRFVWNGYV---LR--QFNCDKMEKFQL 186
            ||:     .:|||:..|:|  ...|..| ||      ..|.||..:   |:  |.:|   ..:.|
Frog   130 FSWPNAGSNFDLTHRAQKQ--AVNSSCE-SG------NWFFWNRLLHVPLKHYQVSC---ADWLL 182

  Fly   187 PLVLGFVSINQVQINGQTFFWSIITRRSVQRAGTRLFCRGSDEQGHVANFVETEQIVEFNGQLTG 251
            .::.|.|.|..|..:.:.....:|:|.|..|||.|...||.|:.|||:|||||||.|..:..::.
Frog   183 KVICGGVEIRTVYASHRKAKACLISRISCARAGARFHIRGVDDDGHVSNFVETEQTVYVDDDVSS 247

  Fly   252 FVQTRGSMPFHWHQLPNLRYKPRPVLVPGKDHLAAC-GLH------------FKEQIRLYGNNVA 303
            |||.|||:|..|.|         |.|..|..||... ||.            .|||   ||..|.
Frog   248 FVQIRGSVPMFWEQ---------PGLQVGSHHLKLTRGLEANAPAFDRHMMLLKEQ---YGKQVL 300

  Fly   304 VNLVDHKGAEGELEATYARLV-REMGNPQVRYESFDFHSECRKMRWDRL-NILIDRLAHEQDQFG 366
            |||:..||.|..|...:.:|: ..:....|...:||:|...:..:.::| |:|..:|..:.::||
Frog   301 VNLLRSKGGEEVLSRAFKKLLWASLHADDVPMINFDYHQIVKGGKIEKLENLLKPQLKLDLEEFG 365

  Fly   367 VYHVFDDGKLVSTQTGVFRTNCIDCLDRTNVVQSMLARRSLTAVLQKLGVLHVGQKVEHASDIFE 431
            |: ...|......|.|.||.||:|||.|||.|||.:|...|...|:.||::.:...:|.    ||
Frog   366 VF-TRGDNLTPRLQKGTFRINCLDCLHRTNSVQSYIALEVLRTQLESLGLVDMKSVMER----FE 425

  Fly   432 SIFKGVWADNADLVSLQYSGTCALKTDFTRTGKRTKSGAMQDGKNSLMRYYLNNFADGQRQDSID 496
            ..:|.:|..|...:|:.::|:.||:      || .|.|.::||..::.|....||.||.:|::||
Frog   426 ESYKSMWTANGHNMSMIFTGSRALE------GK-AKVGKLKDGARTVSRTIQTNFFDGAKQEAID 483

  Fly   497 LFL------------GKYLVNDNEGGAVPSPLES 518
            |.|            |:.|::.:....:||.|:|
Frog   484 LMLMGDFFNEQYADKGRMLMDSSALLVIPSVLKS 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sac1	NP_001189016.1	COG5329	3..566	CDD:227637	168/554 (30%)
Sac1	NP_001189016.1	Syja_N	62..344	CDD:280532	97/309 (31%)
synj2	NP_001135511.1	Syja_N	60..342	CDD:280532	97/309 (31%)
		INPP5c_Synj2	531..863	CDD:197333
		RRM_SF	876..1010	CDD:302621
		TonB_N	<1206..1280	CDD:292650
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D359616at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920