Protein Alignment Klp61F and KIF3B

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: NP_004789.1
• Gene: KIF3B / 9371
• HGNCID: 6320
• Length: 747
• Species: Homo sapiens
• Alignment Length: 813
• Identity: 245/813 - (30%)
• Similarity: 400/813 - (49%)
• Gaps: 158/813 - (19%)

  Fly    15 KSNQNIQVYVRVRPLNSRERCIRSAEVVDV---VGPREVVTRHTLDSKLTKKFTFDRSFGPESKQ 76
            ||:::::|.||.||:|.:|:.....:||||   :|...|........::.|.||||..:...:||
Human     5 KSSESVRVVVRCRPMNGKEKAASYDKVVDVDVKLGQVSVKNPKGTAHEMPKTFTFDAVYDWNAKQ 69

  Fly    77 CDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGIIPRALSHL 141
            .::|.....||::.||.|:|.|:|||||||||||:||.|..        .|....|:||.:..|:
Human    70 FELYDETFRPLVDSVLQGFNGTIFAYGQTGTGKTYTMEGIR--------GDPEKRGVIPNSFDHI 126

  Fly   142 FDEL-RMMEVEYTMRISYLELYNEELCDLLSTDDTTKIRIFD--DSTKKGSVIIQGLEEIPVHSK 203
            |..: |....:|.:|.||||:|.||:.||||.|.|.::.:.:  |:    .|.::.|......|.
Human   127 FTHISRSQNQQYLVRASYLEIYQEEIRDLLSKDQTKRLELKERPDT----GVYVKDLSSFVTKSV 187

  Fly   204 DDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIGKLNLVDLAGSENV 268
            .::..::..|.:.|....|.||..|||||.:|.|.:...|.|::||:.:::||||||||||||..
Human   188 KEIEHVMNVGNQNRSVGATNMNEHSSRSHAIFVITIECSEVGLDGENHIRVGKLNLVDLAGSERQ 252

  Fly   269 SKAGNEKGIRVRETVNINQSLLTLGRVITALVD-RAPHVPYRESKLTRLLQESLGGRTKTSIIAT 332
            :|.| .:|.|::|...||.||..||.||:|||| ::.|:|||:||||||||:||||..||.::|.
Human   253 AKTG-AQGERLKEATKINLSLSALGNVISALVDGKSTHIPYRDSKLTRLLQDSLGGNAKTVMVAN 316

  Fly   333 ISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLKRDL-------MAAR 390
            :.|...::||||:||.||:|||||:|||.||:. .|..:|:|:.|||.:||..|       ...|
Human   317 VGPASYNVEETLTTLRYANRAKNIKNKPRVNED-PKDALLREFQEEIARLKAQLEKRSIGRRKRR 380

  Fly   391 DK-------NGIYLAEETYGEITLKLESQN---------RELNEKMLLLKALKDELQNKEKIFSE 439
            :|       .|....||..||     |.:.         ||..||:        |:: |..|..:
Human   381 EKRREGGGSGGGGEEEEEEGE-----EGEEEGDDKDDYWREQQEKL--------EIE-KRAIVED 431

  Fly   440 VSMSLVEKTQELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEKKELVASHMKTEQVLTTQAQEIL 504
            .|:...||.:.||:.|:.:               :..||.|:..|::.:.:|..:      .::|
Human   432 HSLVAEEKMRLLKEKEKKM---------------EDLRREKDAAEMLGAKIKAME------SKLL 475

  Fly   505 AAADLATDDTHQLHGTIE-RRRELDEKIRRSCD---QFKDRMQDNLEMIGGSLNLYQDQQAALKE 565
            .......|.|::....:| :|:|:.|:.||..:   |.:.|.::.||               |||
Human   476 VGGKNIVDHTNEQQKILEQKRQEIAEQKRREREIQQQMESRDEETLE---------------LKE 525

  Fly   566 QLSQEMVNSSYVSQRLALNSSKSIEMLKEMCAQSLQDQTNLHNKLIGEVMKISDQHSQAFVAKLM 630
            ..|.       :.|.:.:.:.|    ||::.::....:..:|:        :.::|     .|..
Human   526 TYSS-------LQQEVDIKTKK----LKKLFSKLQAVKAEIHD--------LQEEH-----IKER 566

  Fly   631 EQMQQQQLLMSKEIQTNLQVIEENNQRHKAMLDSMQEKFATIIDSSLQSVEEHAKQMH--KKLEQ 693
            ::::|.|..:::|::....:||.        ...::|| :.|::.:....||...::|  .:||.
Human   567 QELEQTQNELTRELKLKHLIIEN--------FIPLEEK-SKIMNRAFFDEEEDHWKLHPITRLEN 622

  Fly   694 LGAMSLPDAEELQNLQEELANERALAQQEDALLESMMMQMEQIKNLRSKNSISMSVHLNKMEESR 758
            ...|..|        ...:..:|.|:|....   |||::.|  ...|::|.:.:.:.:    .||
Human   623 QQMMKRP--------VSAVGYKRPLSQHARM---SMMIRPE--ARYRAENIVLLELDM----PSR 670

  Fly   759 LTRNHRIDDI--------KSGIQDYQKLGIEAS 783
            .||::....|        .:.:||..::.::||
Human   671 TTRDYEGPAIAPKVQAALDAALQDEDEIQVDAS 703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	151/354 (43%)
		SMC_prok_B	<408..728	CDD:274008	61/334 (18%)
		SMC_prok_B	<651..>921	CDD:274008	30/143 (21%)
		Microtub_bind	923..>1004	CDD:464048
KIF3B	NP_004789.1	KISc_KIF3	8..340	CDD:276822	144/344 (42%)
		Smc	<355..>581	CDD:440809	61/299 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	374..412		8/42 (19%)
		Globular	580..747		30/150 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	699..747		2/5 (40%)