DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp61F and KIF18A

DIOPT Version :9

Sequence 1:	NP_476818.1	Gene:	Klp61F / 38135	FlyBaseID:	FBgn0004378	Length:	1066	Species:	Drosophila melanogaster
Sequence 2:	NP_112494.3	Gene:	KIF18A / 81930	HGNCID:	29441	Length:	898	Species:	Homo sapiens

Alignment Length:	948	Identity:	257/948 - (27%)
Similarity:	411/948 - (43%)	Gaps:	182/948 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 NIQVYVRVRPLNSRERCIRSAEVVDVVGPREVV----------------TRHTLDSKLTK--KFT 65
            :::|.|||||.|::|:.....:||.||....:|                |...:..|..|  ||.
Human    11 HMKVVVRVRPENTKEKAAGFHKVVHVVDKHILVFDPKQEEVSFFHGKKTTNQNVIKKQNKDLKFV 75

  Fly    66 FDRSFGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSD 130
            ||..|...|.|.:|:.....|::...||||||||.|||.||.||||||:|:.           .:
Human    76 FDAVFDETSTQSEVFEHTTKPILRSFLNGYNCTVLAYGATGAGKTHTMLGSA-----------DE 129

  Fly   131 IGIIPRALSHLF---DELRMMEVEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSVII 192
            .|::...:.||:   ||::..::..| .:||||:|||::.|||.......:|   :.|:|| |::
Human   130 PGVMYLTMLHLYKCMDEIKEEKICST-AVSYLEVYNEQIRDLLVNSGPLAVR---EDTQKG-VVV 189

  Fly   193 QGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIGKL 257
            .||......|.:::..||:.|.:.|....|.|||.|||||.||.|.:..::........::|.|:
Human   190 HGLTLHQPKSSEEILHLLDNGNKNRTQHPTDMNATSSRSHAVFQIYLRQQDKTASINQNVRIAKM 254

  Fly   258 NLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVD---RAPHVPYRESKLTRLLQE 319
            :|:||||||..|.:| .||.|..|..|||:|||.||.||.||.|   :..|:|||.|||||||::
Human   255 SLIDLAGSERASTSG-AKGTRFVEGTNINRSLLALGNVINALADSKRKNQHIPYRNSKLTRLLKD 318

  Fly   320 SLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQ-----NKPEVNQKLTKKT-VLKEYTEE 378
            ||||..:|.:||.:||.....::|.:||:||:|||:|:     |...||..:|:.. :..|...|
Human   319 SLGGNCQTIMIAAVSPSSVFYDDTYNTLKYANRAKDIKSSLKSNVLNVNNHITQYVKICNEQKAE 383

  Fly   379 IDKLKRDLMAARDKNGIYLAEETYGEITLKLESQNRELNEKMLLLKALKDELQNKEKIFSE-VSM 442
            |..||..|.|..::.. :..|....::.:. ..|.:|:.....:|..|   .||:|:|..| :.:
Human   384 ILLLKEKLKAYEEQKA-FTNENDQAKLMIS-NPQEKEIERFQEILNCL---FQNREEIRQEYLKL 443

  Fly   443 SLVEKTQELKKTEENLLNTKGTLLLTK-KV------------LTKTKRRYKEKK---ELV----- 486
            .::.|..|||...:...:.:..::.:: ||            :.||:|.|.||:   ||.
Human   444 EMLLKENELKSFYQQQCHKQIEMMCSEDKVEKATGKRDHRLAMLKTRRSYLEKRREEELKQFDEN 508

  Fly   487 ---ASHMKTEQVLTTQAQEILAAADLATD-DTHQLHGTIERRRELDEKIRR----SCDQFKDRMQ 543
               ...::.|..|.:|...|  ..:|..| ..|.||   .:.::|..:||.    :|.|.:...|
Human   509 TNWLHRVEKEMGLLSQNGHI--PKELKKDLHCHHLH---LQNKDLKAQIRHMMDLACLQEQQHRQ 568

  Fly   544 DNLEMIGGSLNLYQDQQAALKEQ-LSQEMVNSSYVSQRLALNSSKSIEMLKEMCAQSLQDQ---- 603
            .. .::...|...:.|...|||. ||.....|.:......:...|.:....:...|..|:.
Human   569 TE-AVLNALLPTLRKQYCTLKEAGLSNAAFESDFKEIEHLVERKKVVVWADQTAEQPKQNDLPGI 632

  Fly   604 -----------------------TNL---------HNKLIGEVMKISDQHSQAFVAKLMEQMQQQ 636
                                   |||         ..||:...:|  .||:   :.....|..|.
Human   633 SVLMTFPQLGPVQPIPCCSSSGGTNLVKIPTEKRTRRKLMPSPLK--GQHT---LKSPPSQSVQL 692

  Fly   637 QLLMSKEIQTNLQVIEENNQ--RHKAMLDSMQEKFATIIDSSLQSVEEHAKQMHKKLEQLGAMSL 699
            ...:|||:|..:...|:..:  ::.:.:..|:....|   :|.|::..:... ...|:.|..:::
Human   693 NDSLSKELQPIVYTPEDCRKAFQNPSTVTLMKPSSFT---TSFQAISSNINS-DNCLKMLCEVAI 753

  Fly   700 PDAEELQNLQEELANERALAQQEDALLESMMMQMEQIKNLRSKNSISMSVH------LNKMEESR 758
            |.            |.|....|||  |:|.....|.||:.:.|.....|:.      |.:::.|.
Human   754 PH------------NRRKECGQED--LDSTFTICEDIKSSKCKLPEQESLPNDNKDILQRLDPSS 804

  Fly   759 LTRNHRIDDIKSGIQDYQKLGIEASQSAQAELTSQMEAGMLCLDQGVANCSMLQVHMKNLNQKYE 823
            .:..|.: .:.|.:..|..:...|.:  :.:|||......|..|               :|..:.
Human   805 FSTKHSM-PVPSMVPSYMAMTTAAKR--KRKLTSSTSNSSLTAD---------------VNSGFA 851

  Fly   824 KETNENVGSVRVHHNQVEIICQESKQQLEAVQEKTEVN 861
            |...::        |..|...||:|..:|..:...::|
Human   852 KRVRQD--------NSSEKHLQENKPTMEHKRNICKIN 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	145/374 (39%)
		Kinesin	25..356	CDD:278646	139/354 (39%)
		Microtub_bind	923..>1009	CDD:290642
KIF18A	NP_112494.3	KISc_KIP3_like	11..355	CDD:276821	141/360 (39%)
		Kinesin	17..355	CDD:278646	139/354 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	667..690		6/27 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	830..871		12/63 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910