DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp61F and AT2G37420

DIOPT Version :9

Sequence 1:	NP_476818.1	Gene:	Klp61F / 38135	FlyBaseID:	FBgn0004378	Length:	1066	Species:	Drosophila melanogaster
Sequence 2:	NP_001323679.1	Gene:	AT2G37420 / 818318	AraportID:	AT2G37420	Length:	1039	Species:	Arabidopsis thaliana

Alignment Length:	1126	Identity:	349/1126 - (30%)
Similarity:	560/1126 - (49%)	Gaps:	241/1126 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RQPQKKSNQ--------NIQVYVRVRPLNSRERCIRSAEVVDVVG----PREVVTRHTLDSK-LT 61
            |:|...||:        |:||.:|.:||:..|   :.:.|..|:.    .|||...||:.:| :.
plant    31 RRPDSFSNRLDRDNKEVNVQVILRCKPLSEEE---QKSSVPRVISCNEMRREVNVLHTIANKQVD 92

  Fly    62 KKFTFDRSFGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWE 126
            :.|.||:.|||:|:|..:|...::|::.|||.|::||||||||||||||:||.|...   |...:
plant    93 RLFNFDKVFGPKSQQRSIYDQAIAPIVHEVLEGFSCTVFAYGQTGTGKTYTMEGGMR---KKGGD 154

  Fly   127 DDSDIGIIPRALSHLFDELRMMEVEYTMRISYLELYNEELCDLLSTDDTTK---------IRIFD 182
            ..::.|:||||:.|:||.|.....:|:|::::|||||||:.|||:.||:::         |.:.:
plant   155 LPAEAGVIPRAVRHIFDTLEAQNADYSMKVTFLELYNEEVTDLLAQDDSSRSSEDKQRKPISLME 219

  Fly   183 DSTKKGSVIIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIE 247
            |.  ||||:::||||..|:|.:|:|.|||:|..:|:||.||:|.:|||||:||:|.|||:|..:.
plant   220 DG--KGSVVLRGLEEEVVYSANDIYALLERGSSKRRTADTLLNKRSSRSHSVFTITVHIKEESMG 282

  Fly   248 GEDMLKIGKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVDRAPHVPYRESK 312
            .|:::|.|||||||||||||:.::|...| |.||...||:|||||||||.|||:.:.|||||:||
plant   283 DEELIKCGKLNLVDLAGSENILRSGARDG-RAREAGEINKSLLTLGRVINALVEHSSHVPYRDSK 346

  Fly   313 LTRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTE 377
            |||||::||||:|||.|||||||....:|||||||:||:|||||:||||.||||:|..:||:...
plant   347 LTRLLRDSLGGKTKTCIIATISPSAHSLEETLSTLDYAYRAKNIKNKPEANQKLSKAVLLKDLYL 411

  Fly   378 EIDKLKRDLMAARDKNGIYLAEETYGEITLKLESQNRELNEKMLL--LKALKDELQNKEKIFSEV 440
            |::::|.|:.|||||||:|:|.|.|.:         .|:.:|..:  ::.|::||...|   |||
plant   412 ELERMKEDVRAARDKNGVYIAHERYTQ---------EEVEKKARIERIEQLENELNLSE---SEV 464

  Fly   441 SM----------SLVEKTQELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEKKELVASHMK-TEQ 494
            |.          .|::...:||..:.||.|:...||..|:...:...:.|| ||::.|.|| :|.
plant   465 SKFCDLYETEKEKLLDVESDLKDCKRNLHNSNKDLLDLKENYIQVVSKLKE-KEVIVSRMKASET 528

  Fly   495 VLTTQAQEILAAADLATDDTHQLHGTIERRRELDEKIRRSCDQFKDRMQDNLE------------ 547
            .|..:|:.:......|::|.:.|...::::.:|:...:....:|..::..||:
plant   529 SLIDRAKGLRCDLQHASNDINSLFTRLDQKDKLESDNQSMLLKFGSQLDQNLKDLHRTVLGSVSQ 593

  Fly   548 ----------------------------MIGGSLNLYQDQQAALKEQLSQ----------EMVNS 574
                                        .||.:.:.|....||||| ||:          |..|:
plant   594 QQQQLRTMEEHTHSFLAHKYDATRDLESRIGKTSDTYTSGIAALKE-LSEMLQKKASSDLEKKNT 657

  Fly   575 SYVSQRLALNSSKSIEMLKEMCAQSLQDQT----NLHNKLIGEVMKISDQHSQAFVAKLMEQMQQ 635
            |.|||         ||.:::....|..:.:    ::|| |:.:..|:     .|..|:..||...
plant   658 SIVSQ---------IEAVEKFLTTSATEASAVAQDIHN-LLNDQKKL-----LALAARQQEQGLV 707

  Fly   636 QQLLMSKEIQTNLQVIEEN--NQRHKAMLDSMQEKFATIIDSSLQSVEEHAKQMHKKLEQLGAMS 698
            :.:..::||..:...|..|  ||.|            .::::...|..|.::|:
plant   708 RSMRSAQEISNSTSTIFSNIYNQAH------------DVVEAIRASQAEKSRQL----------- 749

  Fly   699 LPDAEELQNLQEELANERALAQQEDALLESMMMQMEQIKNLRSKNSISMSVHLNKMEESRLTRNH 763
              ||.|:: .:||...|...|..:.:|:         :..|.||.:..:|...:.:.|..:....
plant   750 --DAFEMK-FKEEAEREEKQALNDISLI---------LSKLTSKKTAMISDASSNIREHDIQEEK 802

  Fly   764 RIDDIKSGIQ-----------DY---QKLGIEASQSAQAELTSQMEAGML-CLDQGVANCS---- 809
            |:.:..||:|           ||   :|.....:..|.||..:.|::.:. ||  |.||.|
plant   803 RLYEQMSGMQQVSIGAKEELCDYLKKEKTHFTENTIASAESITVMDSYLEDCL--GRANDSKTLW 865

  Fly   810 -MLQVHMKNLNQKYEKETNENVGSVRVHHNQVEIICQESKQQLEAVQEKTEVNLEQMVDARQQLI 873
             ..:..:||||.||::|.|              :..::..::.|.||::.......| ||.....
plant   866 ETTETGIKNLNTKYQQELN--------------VTMEDMAKENEKVQDEFTSTFSSM-DANFVSR 915

  Fly   874 TEDRQRFIGHATVATDLVQESNRQFSEHAEHQRQQLQICEQELVRFQQSELKTYAPTGTTPSKRD 938
            |.:.     ||.|...|:|:     .|:.|.....::.|..::...|::.       |...|.
plant   916 TNEL-----HAAVNDSLMQD-----RENKETTEAIVETCMNQVTLLQENH-------GQAVSN-- 961

  Fly   939 FVYPRTLVATSPHQEIVRRYRQELDWSDLDTTATIDECSEGEHDVSMHSVQELSETETIMNSTPI 1003
                   :.....|.:::.|  ::|....:|..        :..:::.|:..:.|..|:.:...:
plant   962 -------IRNKAEQSLIKDY--QVDQHKNETPK--------KQSINVPSLDSIEEMRTLFSQNTL 1009

  Fly  1004 E----PVDGVTVKRGCGTTRN 1020
            .    .::.::.|:|.|...|
plant  1010 SEEHTSLEKISTKQGLGEANN 1030

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	186/369 (50%)
		Kinesin	25..356	CDD:278646	175/344 (51%)
		Microtub_bind	923..>1009	CDD:290642	9/89 (10%)
AT2G37420	NP_001323679.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	349	1.000	Domainoid score	I223
eggNOG	1	0.900	-	-		E2759_KOG0243
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	497	1.000	Inparanoid score	I320
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D179272at2759
OrthoFinder	1	1.000	-	-		FOG0002556
OrthoInspector	1	1.000	-	-		otm2697
orthoMCL	1	0.900	-	-		OOG6_102884
Panther	1	1.100	-	-	O	PTHR47970
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1681
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830