DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp61F and AT2G36200

DIOPT Version :9

Sequence 1:	NP_476818.1	Gene:	Klp61F / 38135	FlyBaseID:	FBgn0004378	Length:	1066	Species:	Drosophila melanogaster
Sequence 2:	NP_001189688.1	Gene:	AT2G36200 / 818192	AraportID:	AT2G36200	Length:	1040	Species:	Arabidopsis thaliana

Alignment Length:	1060	Identity:	332/1060 - (31%)
Similarity:	541/1060 - (51%)	Gaps:	131/1060 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SRQPQKKSNQNIQVYVRVRPLNSRERCIRSAEVV---DVVGPREVVTRHTLDSK-LTKKFTFDRS 69
            |.:..|:...|:||.:|.||.:..|....:.:|:   |:  .|||.....:..| :.:.||||:.
plant     2 SSRHDKEKGVNVQVLLRCRPFSDDELRSNAPQVLTCNDL--QREVAVSQNIAGKHIDRVFTFDKV 64

  Fly    70 FGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSS--WEDDSDIG 132
            |||.::|.|:|...|.|::.|||.|:|||:|||||||||||:||.| |....||:  ....::.|
plant    65 FGPSAQQKDLYDQAVVPIVNEVLEGFNCTIFAYGQTGTGKTYTMEG-ECRRSKSAPCGGLPAEAG 128

  Fly   133 IIPRALSHLFDELRMMEVEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTK--------KGS 189
            :||||:..:||.|...:.||::::::|||||||:.|||:.:|.:::...:...|        ||.
plant   129 VIPRAVKQIFDTLEGQQAEYSVKVTFLELYNEEITDLLAPEDLSRVAAEEKQKKPLPLMEDGKGG 193

  Fly   190 VIIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKI 254
            |:::||||..|.|.::::.|||:|..:|:||.|.:|.||||||::|||.:||:|...|||:::|.
plant   194 VLVRGLEEEIVTSANEIFTLLERGSSKRRTAETFLNKQSSRSHSLFSITIHIKEATPEGEELIKC 258

  Fly   255 GKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVDRAPHVPYRESKLTRLLQE 319
            |||||||||||||:|::|...| |.||...||:|||||||||:|||:...|||||:|||||||::
plant   259 GKLNLVDLAGSENISRSGARDG-RAREAGEINKSLLTLGRVISALVEHLGHVPYRDSKLTRLLRD 322

  Fly   320 SLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLKR 384
            ||||||||.||||:||....:|||||||:||||||||:||||||||:.|.|::|:...||::||.
plant   323 SLGGRTKTCIIATVSPAVHCLEETLSTLDYAHRAKNIRNKPEVNQKMMKSTLIKDLYGEIERLKA 387

  Fly   385 DLMAARDKNGIYLAEETYGEITLKLESQNRELNEKMLLLKALKDELQNKEKI------------- 436
            ::.|:|:|||:|:.:|.|    .:.||:.:.:.|:   ::.:..:::|.:|:
plant   388 EVYASREKNGVYMPKERY----YQEESERKVMAEQ---IEQMGGQIENYQKVSFFLLCRSKFYTY 445

  Fly   437 ------------------FSEVSMSLV-------EKTQELKKTEENLLNTKGTLLLTKKVLTKTK 476
                              ..|:....|       :.|.:|..||:||..|...|..|.:.|.|::
plant   446 MWELHVNNGYLHICCDQQLEELQDKYVGQVRECSDLTTKLDITEKNLSQTCKVLASTNEELKKSQ 510

  Fly   477 RRYKEKKELVASHMKTEQVLTTQAQEILAAADLATDDTHQLHGTIERRRELDEKIRRSCDQFKDR 541
            ...|||..:::...|:|.||..||..:.:..:.||.|...||..|.|..:|....|:..|.::..
plant   511 YAMKEKDFIISEQKKSENVLVQQACILQSNLEKATKDNSSLHQKIGREDKLSADNRKVVDNYQVE 575

  Fly   542 MQDNLEMIGGSLNLYQDQQAALKEQ-LSQEMVNSSYVSQ-RLALNSSKSIEMLKEMCAQSLQDQT 604
            :.:.:.      ||:....:.|.:| :..:.||.  :|| ||..::...:||.|::.|.  :|..
plant   576 LSEQIS------NLFNRVASCLSQQNVHLQGVNK--LSQSRLEAHNKAILEMKKKVKAS--RDLY 630

  Fly   605 NLHNKLIGEVMKISDQHSQAFVAKLMEQMQQQQLLMSKEIQTNLQVIEENNQRHKAMLDSMQEKF 669
            :.|.:.:..|:::...::.|.       :::...|.:....:..:.:...::...::.|.:|...
plant   631 SSHLEAVQNVVRLHKANANAC-------LEEVSALTTSSACSIDEFLASGDETTSSLFDELQSAL 688

  Fly   670 ATIIDSSLQSVEEHAKQMHKKLEQLGAMSLPDAEELQNLQEELAN-ERALAQQEDALLESMMMQM 733
            ::..........|..::.|..:||...||...:...|.|.||..| |...|:..|:.:.| ::..
plant   689 SSHQGEMALFARELRQRFHTTMEQTQEMSEYTSTFFQKLMEESKNAETRAAEANDSQINS-IIDF 752

  Fly   734 EQIKNLRSKNSIS---------MSVHLNKMEESRLTRNHRIDD-------------------IKS 770
            ::....:||:...         :|.|:.:..|...:|.|...|                   .|.
plant   753 QKTYEAQSKSDTDKLIADLTNLVSSHIRRQHELVDSRLHNFKDAVSSNKTFLDEHVSAVNNLTKD 817

  Fly   771 GIQDYQKLGIEASQSAQ--AELTSQMEAGM-LCLDQGVANCSMLQVHMKNLNQKYEKETNENVGS 832
            ..:.::...::|...|:  |:.::.....| |.|.|.|.:......|.|..::..::.|::.|..
plant   818 AKRKWETFSMQAENEAREGADFSAAKHCRMELLLQQSVGHAESAFKHCKITHESLKEMTSKQVTD 882

  Fly   833 VRVHHNQVEIICQESKQQLEAVQEKTEVNLEQMVDARQQLITEDRQRFIGHATVATDLVQESNRQ 897
            |   .:.|...| :|.:|.:|..:......|:.|......|.:..:|.......:...:.|:.|.
plant   883 V---SSLVRSAC-DSNEQHDAEVDSARTAAEKDVTKNSDDIIQQIERMSEDEKASVSKILENVRS 943

  Fly   898 FSEHAEHQRQQLQICEQELVR------FQQSELKTYAPTGTTPSKRDFVYPRTLVATS----PHQ 952
            ..:..| ..||.|.|:...:.      |||..:: |.|||.||:|.:...|......|    |.:
plant   944 HEKTLE-SFQQDQCCQARCIEDKAQETFQQQYME-YEPTGATPTKNEPEIPTKATIESLRAMPIE 1006

  Fly   953 EIVRRYRQELDWSDLDTTAT 972
            .:|..:|:...:....|..|
plant  1007 TLVEEFRENNSYESFATKET 1026

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	185/361 (51%)
		Kinesin	25..356	CDD:278646	174/344 (51%)
		Microtub_bind	923..>1009	CDD:290642	14/54 (26%)
AT2G36200	NP_001189688.1	KISc_BimC_Eg5	10..368	CDD:276815	185/361 (51%)
AT2G36200	NP_001189688.1	Kinesin	18..359	CDD:278646	174/344 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	349	1.000	Domainoid score	I223
eggNOG	1	0.900	-	-		E2759_KOG0243
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	497	1.000	Inparanoid score	I320
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D179272at2759
OrthoFinder	1	1.000	-	-		FOG0002556
OrthoInspector	1	1.000	-	-		otm2697
orthoMCL	1	0.900	-	-		OOG6_102884
Panther	1	1.100	-	-	LDO	PTHR47970
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1681
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830