Protein Alignment Klp61F and Kif19b

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: XP_006249035.1
• Gene: Kif19b / 679924
• RGDID: 1598146
• Length: 976
• Species: Rattus norvegicus
• Alignment Length: 1111
• Identity: 268/1111 - (24%)
• Similarity: 465/1111 - (41%)
• Gaps: 230/1111 - (20%)

  Fly     5 GGNTSRQPQKKSNQNIQVYVRVRPLNSRERCIRSAEVVDVVGPREVV-------TRHTLDSKLTK 62
            |..|.|:.:.| :|.:.|.:|:|||||.|....:..:...||.:.||       ...||.:..::
  Rat    14 GSPTLREMEPK-DQQLMVALRIRPLNSTELEEGATVIAHKVGDQVVVLMDPGEDPEDTLRAHRSR 77

  Fly    63 K--FTFDRSFGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSW 125
            :  |.||..|..::.|..||.|.:..|:|.|::|||.||||||.:|.||||||:|.
  Rat    78 ERTFIFDTVFDQQASQETVYRVTIQHLVEGVISGYNATVFAYGPSGAGKTHTMLGM--------- 133

  Fly   126 EDDSDIGIIPRALSHLFDELRMME--VEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKG 188
              |::.||..:.|:.||..:...:  :||::.:||||:|||.:.|||: ..:..:.:.:||  :|
  Rat   134 --DAEPGIYLQTLTDLFQAIEETQDNMEYSVSMSYLEIYNEVIRDLLN-PSSGFLELREDS--RG 193

  Fly   189 SVIIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLK 253
            |:.|.|:.|:...:..::.:||.||..:|....|..|..|||||.|..:.||.|..|.:..:.::
  Rat   194 SIQIAGITEVSTSNAQEIMQLLTKGNRQRTQEPTATNKTSSRSHAVLQVTVHQRSRGGDLAEEVR 258

  Fly   254 IGKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVD----RAPHVPYRESKLT 314
            :|:|.:|||||||..::..| :|.|::|..:||:|||.||..|.||.:    ||.:|.:|:||||
  Rat   259 LGRLFMVDLAGSERAAQTQN-RGKRMKEGAHINRSLLALGNCINALSEKGGSRAQYVNFRDSKLT 322

  Fly   315 RLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEI 379
            |||:::|||.::|.:||.|||.....||:.:||.||:|||||:.:.:.| .|.....:.:||:.|
  Rat   323 RLLKDALGGNSRTVMIAHISPASTSFEESRTTLLYAYRAKNIKTRVKRN-LLNVSYRIAQYTDVI 386

  Fly   380 DKLKRDLMAARDKNGIYLAEETYGEITLKLESQNRELNEKMLLLKALKDELQNKEKIFSEVSMSL 444
            ..|:|::                                         :.|::|
  Rat   387 SDLRREI-----------------------------------------EHLKSK----------- 399

  Fly   445 VEKTQELKKTEENLLNTKGTL---------LLTKKVLTKTKRRYKEKKELVASHMKTE----QVL 496
            :||..:.||::.::|:.:.|:         |...|:..:....:||:.|:..|.::.|    ::.
  Rat   400 IEKQDKEKKSDPSVLDIQVTVPQDAEEDSRLQMNKIRAQLIGAFKEQMEMRRSLVELENTNIELH 464

  Fly   497 TTQAQEILAAADLATDDTHQLHGTIERRRELDEKIRRSCDQFKDRMQDNLEMIGGSLNLY---QD 558
            ...::.:|..||. ....|  |..:::.::..|.:....::.:......:.:....:||.   |.
  Rat   465 IDMSRHLLTIADW-EKTLH--HANMDKSKKDKEPVDADGEEVEASEPPEVALAREEVNLLLAEQQ 526

  Fly   559 QQAALKEQLSQEMVNSSYVSQRL------ALNSSKSIEMLKEMC-AQSLQ-DQTNLH-------N 608
            :.||||..|.|.:.::...:.::      .:.|....|:|:.:| |..|: :.|.|.       |
  Rat   527 KTAALKAGLEQRLAHAKQKASQMEKLLPRQVTSEDQREVLQLLCRAHELEVENTELQADNLCRKN 591

  Fly   609 KLIGEVMKISDQHSQAFVAKLMEQMQ-QQQLLMSKEIQTNLQVIEENNQRHKAMLDSMQEKFATI 672
            .|..:...|...|....:.:  |.:| |:||:..|    .|.|.|...|:::.....:.|
  Rat   592 LLCQKDFVIQRYHQHRLLCE--EVIQGQRQLMQDK----GLSVPEPLEQQYRLYSRELGE----- 645

  Fly   673 IDSSLQSVEEHAKQMHKKLEQLGAMSLPDAEELQNLQEELANERALAQQEDALLESMMMQMEQIK 737
              .:|..:......|...|:....|::..|...:...|.|.:.|.|.......|..|:::.:...
  Rat   646 --GTLDRLLLQLSVMSSSLQDGPIMNVSPAPTEETSGEPLGDRRDLPWGATFELPPMLLERDSDG 708

  Fly   738 NLRSKNSISMSVHLNKMEESRLTRNHRIDDIKSGIQDYQKLGIEA-----SQSAQAELTSQMEAG 797
            | ||..|..:. .|.|.:........||......::....||:::     ..:|..||.:...||
  Rat   709 N-RSSKSTPLR-RLGKQDSLLPPPALRILLTPPMLEKPSALGVKSLVSRLQATAGLELRTPQPAG 771

  Fly   798 ML---------CLDQGVANCSMLQVHMKNLNQKYEKETNENVGSVRVHHNQVEIICQESKQQLEA 853
            .:         ..:..:...|:..:......:.|::|..                |.:|:....|
  Rat   772 EMNSPPLSAQALKEMALGTKSIALIAANRRCKVYDREGG----------------CLDSRDPSPA 820

  Fly   854 VQEKTEVNLEQMVDARQQLITEDRQRFIGHATVATDLVQESNRQFSEHAEHQRQQLQICEQELVR 918
                         |.|....:..|.|         .|.:::.|:.|.......||||..|:....
  Rat   821 -------------DWRWPHASPSRDR---------SLDRKAGRKRSPSFTWSLQQLQALEKHQPS 863

  Fly   919 FQQSELKTYAPTGTTPSK---RDFVYPRTLVATSPHQEIVRRYRQELDWSDLDTTATIDECSEGE 980
            .:.......:|....|.|   |.| :|...|..:                           |:.:
  Rat   864 MEHPSESQLSPAHLQPPKPAGRSF-FPAVPVPVA---------------------------SKTK 900

  Fly   981 HDVSMHSVQELSETETIMNSTPIEPVDGVTVKRGCGTTRNSNSNALKPPVATGGKRSSSLSRSLT 1045
            ..:|.|:.:.:.:...:..:.|             .....||:.:.:||:.....|.|:.||...
  Rat   901 PSLSFHTEENVLQVPEVSFTFP-------------SAMWQSNTASSRPPLLPRDIRGSTDSRGRR 952

  Fly  1046 PSKTSP 1051
            .|...|
  Rat   953 QSPLPP 958

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	140/362 (39%)
		SMC_prok_B	<408..728	CDD:274008	63/351 (18%)
		SMC_prok_B	<651..>921	CDD:274008	47/283 (17%)
		Microtub_bind	923..>1004	CDD:464048	11/83 (13%)
Kif19b	XP_006249035.1	KISc_KIP3_like	27..364	CDD:276821	136/351 (39%)
		SMC_prok_B	<386..>620	CDD:274008	48/290 (17%)