DRSC/TRiP Functional Genomics Resources

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Protein Alignment Klp61F and KIF13A

DIOPT Version :9

Sequence 1:NP_476818.1 Gene:Klp61F / 38135 FlyBaseID:FBgn0004378 Length:1066 Species:Drosophila melanogaster
Sequence 2:NP_071396.4 Gene:KIF13A / 63971 HGNCID:14566 Length:1805 Species:Homo sapiens


Alignment Length:1196 Identity:302/1196 - (25%)
Similarity:509/1196 - (42%) Gaps:323/1196 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 SNQNIQVYVRVRPLNSRERCIRSAEVVDVVGPREVV------TRHTLDSKLTKKFTFDRSFG--P 72
            |:..::|.|||||:|.||..:.:..||::.|.:.|:      |:.. :.|..|.|.||..|.  .
Human     2 SDTKVKVAVRVRPMNRRELELNTKCVVEMEGNQTVLHPPPSNTKQG-ERKPPKVFAFDYCFWSMD 65

  Fly    73 ESK------QCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDI 131
            ||.      |..|:..:...::|:...|||..:|||||||:||:.:|:|:  ||         .:
Human    66 ESNTTKYAGQEVVFKCLGEGILEKAFQGYNACIFAYGQTGSGKSFSMMGH--AE---------QL 119

  Fly   132 GIIPRALSHLFDELRMMEVE---YTMRISYLELYNEELCDLL---STDDTTKIRIFDDSTKKGSV 190
            |:|||....||..:.:.:.|   :.:.:||:|:|||::.|||   .:..:.|:|    ..|....
Human   120 GLIPRLCCALFKRISLEQNESQTFKVEVSYMEIYNEKVRDLLDPKGSRQSLKVR----EHKVLGP 180

  Fly   191 IIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVV----HIRENGIEGEDM 251
            .:.||.::.|.|.:|:..|:.:|.:.|..|.|.||.:|||||.||:|::    :..::|..||  
Human   181 YVDGLSQLAVTSFEDIESLMSEGNKSRTVAATNMNEESSRSHAVFNIIITQTLYDLQSGNSGE-- 243

  Fly   252 LKIGKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVDRA------PHVPYRE 310
             |:.|::||||||||.|||.| ..|.|::|..|||:||.|||.||::|.|:|      ..||||:
Human   244 -KVSKVSLVDLAGSERVSKTG-AAGERLKEGSNINKSLTTLGLVISSLADQAAGKGKSKFVPYRD 306

  Fly   311 SKLTRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEY 375
            |.||.||:::|||.::||:||||||...:.|||||||.||.|||.|.|...||:....| |::|.
Human   307 SVLTWLLKDNLGGNSQTSMIATISPAADNYEETLSTLRYADRAKRIVNHAVVNEDPNAK-VIREL 370

  Fly   376 TEEIDKLKRDLMAARDKNGIYLAEETYGEITLKLESQNRELNEKMLLLKA--LKDELQNKEKIFS 438
            .||::||:..|..|.                               .:||  ||::|:..||:..
Human   371 REEVEKLREQLSQAE-------------------------------AMKAPELKEKLEESEKLIK 404

  Fly   439 EVSMSLVE---KTQELKKTEENLLNTKGTLLLTKKVLTKTKRRY-------KEKKELVASHMKTE 493
            |::::..|   ||:|:.:..:..|.:.|..|....:.....:.|       ....||:..::|..
Human   405 ELTVTWEEKLRKTEEIAQERQRQLESMGISLEMSGIKVGDDKCYLVNLNADPALNELLVYYLKDH 469

  Fly   494 -QVLTTQAQEIL----------AAADLATD---------------------DTHQL-HGTIER-- 523
             :|....:|:|.          ...|:|:|                     .|.|| ||  :|  
Human   470 TRVGADTSQDIQLFGIGIQPQHCEIDIASDGDVTLTPKENARSCVNGTLVCSTTQLWHG--DRIL 532

  Fly   524 -------RRELDEKIRRSCDQFKDRMQD-------------------------NLEMIGGSLNL- 555
                   |..|.::.||  |..||..::                         .:|:|..:||. 
Human   533 WGNNHFFRINLPKRKRR--DWLKDFEKETGPPEHDLDAASEASSEPDYNYEFAQMEVIMKTLNSN 595

  Fly   556 --YQDQQAALKEQLSQEMVNSSYVSQRLALNSSKSIEMLKEMCAQSLQDQTNLHNKLI------- 611
              .|:....|::|..:|. .|:...|||..  .:.:|.|::..:...|.|::..::|.       
Human   596 DPVQNVVQVLEKQYLEEK-RSALEEQRLMY--ERELEQLRQQLSPDRQPQSSGPDRLAYSSQTAQ 657

  Fly   612 GEVMKISDQHSQAF---VAKLMEQMQQQQLL----------MSK--EIQTNLQVIEEN---NQRH 658
            .:|.:.:::..:.|   :|||.||:.:...|          |||  :.|..||:...|   |::.
Human   658 QKVTQWAEERDELFRQSLAKLREQLVKANTLVREANFLAEEMSKLTDYQVTLQIPAANLSANRKR 722

  Fly   659 KAMLDSMQEKFATIIDSSLQSVEEHAKQMHKKLEQLGAMSLPDAEELQNLQEELANERALAQQED 723
            .|:                  |.|.|.|:.:|.:.....::   |:|:|   :|.:.|.|.|:  
Human   723 GAI------------------VSEPAIQVRRKGKSTQVWTI---EKLEN---KLIDMRDLYQE-- 761

  Fly   724 ALLESMMMQMEQIKNLRSKNSISMSVHLNKMEESRLTRNHRIDDIKSGIQDYQKLGIE------- 781
                                      ...|:.|::.....|.|......:::..:|:.       
Human   762 --------------------------WKEKVPEAKRLYGKRGDPFYEAQENHNLIGVANVFLECL 800

  Fly   782 ----ASQSAQAELTSQME-AGMLCLDQGVANCSMLQVHMKNLNQKYEKETNEN---VGSVRVHHN 838
                ..|.|...::.|.| ||.|       :..:::|......:..|.:::||   .||:.|..:
Human   801 FCDVKLQYAVPIISQQGEVAGRL-------HVEVMRVTGAVPERVVEDDSSENSSESGSLEVVDS 858

  Fly   839 QVEIICQESKQQLEA-VQEKT--EVNLEQMVDARQQLITEDRQRFIGHATVATDLV-------QE 893
            ..|||.:..|..... ::|.|  .:||...|..:.....:      ..:|||..:|       |.
Human   859 SGEIIHRVKKLTCRVKIKEATGLPLNLSNFVFCQYTFWDQ------CESTVAAPVVDPEVPSPQS 917

  Fly   894 SNRQFSEHAEHQRQQLQICEQELVRFQQS---ELKTY----APTGTTPSKRDFVYPRTLVATSPH 951
            .:.|::....|.:..:....:|.:.|...   .::.:    |..|::..:.|.::.:|.......
Human   918 KDAQYTVTFSHCKDYVVNVTEEFLEFISDGALAIEVWGHRCAGNGSSIWEVDSLHAKTRTLHDRW 982

  Fly   952 QEIVRRYRQELDWSDLDTTATIDECSE-GEH---------DVSMHSVQELSETETIMNSTPIEPV 1006
            .|:.||         ::...:|.|.:| ||:         ||:...:.:|.:..:......::||
Human   983 NEVTRR---------IEMWISILELNELGEYAAVELHQAKDVNTGGIFQLRQGHSRRVQVTVKPV 1038

  Fly  1007 DG-----------VTVKRGCGTTRNS 1021
            ..           ::|..||.|.|::
Human  1039 QHSGTLPLMVEAILSVSIGCVTARST 1064

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Klp61FNP_476818.1 KISc_BimC_Eg5 17..365 CDD:276815 149/377 (40%)
Kinesin 25..356 CDD:278646 143/360 (40%)
Microtub_bind 923..>1009 CDD:290642 17/110 (15%)
KIF13ANP_071396.4 KISc_KIF1A_KIF1B 5..359 CDD:276816 147/373 (39%)
Kinesin_assoc 356..468 CDD:318424 29/143 (20%)
FHA 446..543 CDD:238017 17/98 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 556..575 0/18 (0%)
SMC_N <606..771 CDD:330553 42/219 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 633..656 3/22 (14%)
KIF1B 748..792 CDD:315155 10/74 (14%)
DUF3694 <1215..1279 CDD:315198
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1385..1404
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1507..1531
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1612..1645
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1749..1779
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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