Protein Alignment Klp61F and KIF17

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: XP_047282102.1
• Gene: KIF17 / 57576
• HGNCID: 19167
• Length: 1063
• Species: Homo sapiens
• Alignment Length: 1156
• Identity: 311/1156 - (26%)
• Similarity: 481/1156 - (41%)
• Gaps: 252/1156 - (21%)

  Fly    16 SNQNIQVYVRVRPLNSRERCIRSAEVVDVVGPRE--VVTRHTLDSKLTKKFTFDRSFGPESKQCD 78
            :::.::|.||.||:|.|||.:|...||.|...|.  .:.......:..|:||||.::..:.....
Human     2 ASEAVKVVVRCRPMNQRERELRCQPVVTVDCARAQCCIQNPGAADEPPKQFTFDGAYHVDHVTEQ 66

  Fly    79 VYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGIIPRALSHLFD 143
            :|:.:..||:|.|..|||.|:|||||||:||:.||.|..        :..|..||||||..|:|:
Human    67 IYNEIAYPLVEGVTEGYNGTIFAYGQTGSGKSFTMQGLP--------DPPSQRGIIPRAFEHVFE 123

  Fly   144 ELRMME-VEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSVIIQGLEEIPVHSKDDVY 207
            .::..| .::.:|.||||:|||::.|||..|...|:.: .:..:|| |.::||....|||.....
Human   124 SVQCAENTKFLVRASYLEIYNEDVRDLLGADTKQKLEL-KEHPEKG-VYVKGLSMHTVHSVAQCE 186

  Fly   208 KLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIGKLNLVDLAGSENVSKAG 272
            .::|.|.:.|....||||..|||||::|:|.:.:......|:|.|:.||||||||||||..||.|
Human   187 HIMETGWKNRSVGYTLMNKDSSRSHSIFTISIEMSAVDERGKDHLRAGKLNLVDLAGSERQSKTG 251

  Fly   273 NEKGIRVRETVNINQSLLTLGRVITALVD-RAPHVPYRESKLTRLLQESLGGRTKTSIIATISPG 336
             ..|.|::|...||.||..||.||:|||| |..|||||:||||||||:||||.|||.::|.:||.
Human   252 -ATGERLKEATKINLSLSALGNVISALVDGRCKHVPYRDSKLTRLLQDSLGGNTKTLMVACLSPA 315

  Fly   337 HKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLKRDLMAARDKNGIYLAEET 401
            ..:.:||||||.||:|||||:|||.:|:. .|..:|:||.|||.|||..|......:.:
Human   316 DNNYDETLSTLRYANRAKNIRNKPRINED-PKDALLREYQEEIKKLKAILTQQMSPSSL------ 373

  Fly   402 YGEITLKLESQNRELNEKMLLLKALKDELQNKEKIFSE-VSMSLVEKTQELKKTEENLLNTKGTL 465
                            ..:|..:...|.:|.:||:..: |....||..::|.:.|
Human   374 ----------------SALLSRQVPPDPVQVEEKLLPQPVIQHDVEAEKQLIREE---------- 412

  Fly   466 LLTKKVLTKTKRRYKEKKELVASHMKTEQVLTTQAQEILAAADLATDDTHQLHGTIERRRELDEK 530
                         |:|:...:.:..|.||....:.:|.:.|...:.|         .|...|:|.
Human   413 -------------YEERLARLKADYKAEQESRARLEEDITAMRNSYD---------VRLSTLEEN 455

  Fly   531 IRRSCDQ-------FKDRMQDNLEMIGGS--------LNLYQDQQAALKEQLSQEMVNSSYVSQR 580
            :|:..:.       :|..:....|....:        ..:.:.:..:..:.|..:.|:.:.||.|
Human   456 LRKETEAVLQVGVLYKAEVMSRAEFASSAEYPPAFQYETVVKPKVFSTTDTLPSDDVSKTQVSSR 520

  Fly   581 LA----LNSSKSIEMLKEMCAQSLQDQTNLHNKLIG-------EV-MKISDQHSQAFVAKLMEQM 633
            .|    :..|||...|....:.|| ::|::.....|       || |...:..|:.|:.:.:.|.
Human   521 FAELPKVEPSKSEISLGSSESSSL-EETSVSEAFPGPEEPSNVEVSMPTEESRSRYFLDECLGQE 584

  Fly   634 QQQQLLMSKEIQTNLQVIEENNQRHKAMLDSMQEKFATI------IDSSLQSVEEHAKQMHKKLE 692
            ....||.    :.|....||..:.....|..:|:.||.:      :.|::...:.....:.|...
Human   585 AAGHLLG----EQNYLPQEEPQEVPLQGLLGLQDPFAEVEAKLARLSSTVARTDAPQADVPKVPV 645

  Fly   693 QLGAM--------SLPDAEELQNL----QEELANERAL---------------------AQQED- 723
            |:.|.        :.|:||...:.    :.:||:|.||                     ||.|.
Human   646 QVPAPTDLLEPSDARPEAEAADDFPPRPEVDLASEVALEVVRTAEPGVWLEAQAPVALVAQPEPL 710

  Fly   724 -----------------------------------ALLESMMMQMEQIKNLRSKNSISMSVHLNK 753
                                               .|||..::..||.||...|...........
Human   711 PATAGVKRESVGMEVAVLTDDPLPVVDQQQVLARLQLLEQQVVGGEQAKNKDLKEKHKRRKRYAD 775

  Fly   754 MEESRLTRNHRIDDIKSGIQDYQKLGIEASQSAQAELTSQMEAGMLCLDQGVANCSMLQVHMKNL 818
            ....:|....:..|..||  |:..|.:..|...:....|::      |::........:|.:|:|
Human   776 ERRKQLVAALQNSDEDSG--DWVLLNVYDSIQEEVRAKSKL------LEKMQRKLRAAEVEIKDL 832

  Fly   819 NQKYEKETNENVGSVRVHHNQVEIICQESKQQLEAVQ-----EKTEVNLEQMVDARQQLITEDRQ 878
            ..:::.|..:.:.::|.......::    :|.||.||     :....|||:::  |:....||..
Human   833 QSEFQLEKIDYLATIRRQERDSMLL----QQLLEQVQPLIRRDCNYSNLEKIL--RESCWDEDNG 891

  Fly   879 RF-IGHATVA-TDLVQESNRQFSEHAEHQRQQLQICEQELVRFQQSELKTYAPTGTTPSKRDFVY 941
            .: |.|..:. |.|.|   .|.........:.||         |....:|:..|.|.........
Human   892 FWKIPHPVITKTSLPQ---FQLGHRTNQPAKPLQ---------QTMASRTWRTTATGSCSVGATV 944

  Fly   942 PRTLVATSPHQEIVRRYRQELDWSDLDTTATIDECSEG--EHDVSMHSVQELSETETIMNSTPIE 1004
             :||.||:               |||...|.....:.|  .|..:.|.. ..:.:.|.:.|.|..
Human   945 -KTLPATT---------------SDLSGPARSSAQTPGRASHITTRHQA-SAAHSATTLPSHPPR 992

  Fly  1005 PVDGVTVKRGCGTTRNSNSNALKPPVATGGKRSSSLSRSLTPSKTSPRGSP 1055
            |                    ||.|  :.|..:||.|.||:|..:||...|
Human   993 P--------------------LKCP--SPGPSASSPSTSLSPRPSSPHPCP 1021

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	159/351 (45%)
		SMC_prok_B	<408..728	CDD:274008	70/422 (17%)
		SMC_prok_B	<651..>921	CDD:274008	62/351 (18%)
		Microtub_bind	923..>1004	CDD:464048	17/82 (21%)
KIF17	XP_047282102.1	Motor_domain	4..335	CDD:473979	153/341 (45%)