DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp61F and kif1c

DIOPT Version :9

Sequence 1:	NP_476818.1	Gene:	Klp61F / 38135	FlyBaseID:	FBgn0004378	Length:	1066	Species:	Drosophila melanogaster
Sequence 2:	XP_009300278.1	Gene:	kif1c / 570771	ZFINID:	ZDB-GENE-090312-119	Length:	1185	Species:	Danio rerio

Alignment Length:	1018	Identity:	244/1018 - (23%)
Similarity:	420/1018 - (41%)	Gaps:	209/1018 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SNQNIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHTLDSKLTKKFTFDRSFGPESKQCD-- 78
            ::.:::|.|||||.||||....:..|:.:......:|......:..|.||||.|:...|.:.|
Zfish     2 ASSSVKVAVRVRPFNSRETNRGAKCVIQMQDKSTCITNPKQPKESPKNFTFDYSYWSHSSEEDPS 66

  Fly    79 ------VYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGIIPRA 137
                  ||..:...::.....|||..:|||||||.||::||:|.         :|....||||:.
Zfish    67 FASQRKVYQDIGEEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGK---------QDPGQQGIIPQM 122

  Fly   138 LSHLF---DELRMMEVEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSVIIQGLEEIP 199
            ...||   .|....::.:::.:||:|:|.|.:.|||:......:|:.:....  ...::.|.::.
Zfish   123 CEDLFRQTAENTDPDLSFSVEVSYMEIYCERVRDLLNPKSKGALRVREHPIM--GPYVEDLSKMA 185

  Fly   200 VHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIV-VHIRENGIEGEDMLKIGKLNLVDLA 263
            |.:..|:..|::.|.:.|..|.|.||..|||||.||:|: ...|.:.:...|..|:.|::|||||
Zfish   186 VTNYSDIADLMDTGNKARTVAATNMNETSSRSHAVFTILFTQHRHDHMTSLDTEKVSKISLVDLA 250

  Fly   264 GSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVD------------RAPHVPYRESKLTRL 316
            |||....:| .||:|::|..|||:||.|||:||:||.|            |:..:|||:|.||.|
Zfish   251 GSERADSSG-AKGMRLKEGANINKSLTTLGKVISALADMVSPPQHGSKKRRSDFIPYRDSVLTWL 314

  Fly   317 LQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDK 381
            |:|:|||.::|::||.:||...:.|||||||.||.|||.|:....:|:....:.| :|..||:::
Zfish   315 LRENLGGNSRTAMIAALSPADINYEETLSTLRYADRAKQIKCNAVINEDPNARLV-RELKEEVNR 378

  Fly   382 LKRDLMAARDKNGIYLAEETYGEITL---------------------KLESQNRELNEKMLLLKA 425
            ||..|::....|.|..:....|...|                     .:|........:.:..:.
Zfish   379 LKELLLSQGLSNLITASGSETGHPALAGVLGEPHQPSLPYVQSTSDAPMEGVTTTSPSEPISKEE 443

  Fly   426 LKDELQNKEKIFSEVSMSLVE---KTQELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEKKELVA 487
            ..:.|:..|||.:|::.:..|   ||:|:::..|:||...|..:             ||....|.
Zfish   444 AAERLKETEKIIAELNETWEEKLRKTEEIRQDRESLLAEMGVSV-------------KEDGGTVG 495

  Fly   488 --SHMKTEQVLTTQAQEILAAADLATDDTHQLHGTIERRRELDEKIRRSCDQFKD-------RMQ 543
              |..||..::......:::...:     :.:...:.|..:.|..||.|....|:       .:.
Zfish   496 VFSPKKTPHLVNLNEDPLMSECLI-----YYIKDGVTRVGQEDVDIRLSGQFIKELHCVFCSEIN 555

  Fly   544 DNLEMIGGSLNLYQDQQAALKEQLSQE-MVNSSYVSQRLALNSSKSIEMLKEMCAQ-SLQDQTNL 606
            :|.|::           ..|:..:..| .||...|::.:.|.....|.|.|....: :..:|..|
Zfish   556 ENNEVV-----------VTLEPLVGAETYVNGKQVTEGVVLKQGNRIVMGKNHVFRFNHPEQARL 609

  Fly   607 HNKLIGEVMKISDQHSQAFVAKLMEQMQQQQLLMSKEIQTNLQVIEENNQRHKAMLDSMQEKFAT 671
            ..:......:..:....::..|  |.:::|.:.:.:|::..||.:|...::.|...|.:.|:...
Zfish   610 ERERSATQEQQGEPVDWSYAQK--ELLEKQGIDIKQEMEKRLQDLENQYRKEKEEADQILEQQRL 672

  Fly   672 II------DSSLQSVEEHAKQMHKKLEQLGAMSLPDAEELQNLQEELANERALAQQEDALLESMM 730
            ..      ||..:|.||..:.:....|:|      .|.::|::.::.....:..::|.
Zfish   673 YADSDSGDDSDKRSCEESWRLISSLREKL------PANKMQSIVKKCGLPSSGKRREP------- 724

  Fly   731 MQMEQIKNLR-------SKNSISMSVHLNKMEESRLTRNHRIDDIKSGIQDYQKLGIEASQSAQA 788
            :::.||...|       ||..:|:. .|.......:.....:.|.|...|:.:.|.|
Zfish   725 LRVYQIPQRRRIPATQESKQRLSVE-ELRTQAVKEICYEVALGDFKHTRQEIEALAI-------- 780

  Fly   789 ELTSQMEAGMLCLDQGVANCSMLQVHMKNLNQKY------EKETNENV----------------- 830
                                    |.||.|.:.|      |:||.::|
Zfish   781 ------------------------VRMKELCRTYCQKDPQERETWKSVAKDVCETVGIGEEEGDR 821

  Fly   831 --------------------GSVRVHHNQVEIICQESKQQLEAVQEKTEVNLEQMVDARQ----Q 871
                                |.::.|.:::..|.||.|.|.....|:.....::||...:    .
Zfish   822 EDRIAAAAAGGGSEGGKTDMGDLKAHIDKLTDILQEVKLQNNMKDEEIRSLRDRMVKMEKIFPVD 886

  Fly   872 LITEDRQRFIGHATVATDLVQESNRQFSEHAEHQRQQLQICEQ 914
            :..:|.....|.|.|.....|.:.|.........|.:.|..|:
Zfish   887 VKGDDEDVEFGGARVEEPTAQVNRRNEDSGYRRGRHRWQYPEK 929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	134/371 (36%)
		Kinesin	25..356	CDD:278646	130/354 (37%)
		Microtub_bind	923..>1009	CDD:290642
kif1c	XP_009300278.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	133/368 (36%)
		KISc	5..361	CDD:214526	133/367 (36%)
		Kinesin_assoc	358..526	CDD:292801	32/186 (17%)
		FHA	503..603	CDD:238017	17/115 (15%)
		FHA	<513..601	CDD:224630	17/103 (17%)
		MPLKIP	967..>1099	CDD:292140
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000