Protein Alignment Klp61F and kif21b

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: XP_073772347.1
• Gene: kif21b / 570502
• ZFINID: ZDB-GENE-130530-537
• Length: 1669
• Species: Danio rerio
• Alignment Length: 1088
• Identity: 290/1088 - (26%)
• Similarity: 477/1088 - (43%)
• Gaps: 208/1088 - (19%)

  Fly    19 NIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHTLDSKLTKKFTFDRSFGPESKQCDVYSVV 83
            :::|.:|:||..::|: |....:...|.|.|.......|    |.||:|..|..::.|..:||..
Zfish     8 SVKVSLRIRPQMAKEK-IEGCHICTSVTPGEPQVLLGKD----KAFTYDFVFDLDAHQQQIYSAC 67

  Fly    84 VSPLIEEVLNGYNCTVFAYGQTGTGKTHTM-VGNETAELKSSWEDDSDIGIIPRALSHLFDELRM 147
            |..|||....|||.|||||||||:|||:|| .|.:.    |..||:.  ||||||:..||..::.
Zfish    68 VHKLIEGCFEGYNATVFAYGQTGSGKTYTMGTGFDV----SVSEDEQ--GIIPRAVHQLFQGIQK 126

  Fly   148 MEVE----------YTMRISYLELYNEELCDLL-STDD------TTKIRIFDDSTKKGSVIIQGL 195
            ..:|          :.:...:|||||||:.||. ||.|      .:.|:|.:|.:  |.:...|:
Zfish   127 RRLEAQSADIPPPDFKVSAQFLELYNEEILDLFDSTRDPEARGRKSNIKIHEDGS--GGIYTTGV 189

  Fly   196 EEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSI------------VVHIRENGIEG 248
            ....|.|:|::.:.|:.|...|.||:|.|||||||||.:|:|            :|:...||:..
Zfish   190 TSRLVSSEDELLQCLKLGALSRTTASTQMNAQSSRSHAIFTIHLCQMRVCPQPQLVNGELNGVSD 254

  Fly   249 EDMLK------IGKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVD---RAP 304
            ..|.:      ..|.:.|||||||.:.:.| ..|.|.||.::||..||.||.||:||.|   ||.
Zfish   255 GSMSQSEYETLSAKFHFVDLAGSERLKRTG-ATGERAREGISINCGLLALGNVISALGDQSKRAG 318

  Fly   305 HVPYRESKLTRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKK 369
            |||||:||||||||:||||.::|.:||.:||..:|..|||:||:||:||:||:||..|||..|.:
Zfish   319 HVPYRDSKLTRLLQDSLGGNSRTVMIACVSPSDRDFMETLNTLKYANRARNIKNKVIVNQDKTSQ 383

  Fly   370 TVLKEYTEEIDKLKRDLMAARDKNGIYLAEETYGEITLKLESQ--NRELNEKMLLLKALKDELQN 432
            .: .....||.:|:.::|..:....:...|.:.|...|..|:.  .||.:...:.:||:::.:.:
Zfish   384 QI-SALRAEIARLQMEIMEYKAGKRVACDEGSEGFSDLFQENSMLQRENDTLRMRVKAMQETIDH 447

  Fly   433 KEKIFSEVSMSLVEKTQELKKTEENLLNTKGTLLLTKKV---LTKTKRRYKEKKELVASHMKTEQ 494
                                      |||:.|.|||..|   ||||....:|...|:.::::
Zfish   448 --------------------------LNTRVTQLLTNGVNLLLTKTGETNEEIGNLIQNYIR--- 483

  Fly   495 VLTTQAQEILAAADLATDDTHQLHGTIERRRELDEKIRRSCDQFKDR-----MQDNLEMIGGSLN 554
                              :..:|...:.....::|.:|||..:...|     ...:...||.|.:
Zfish   484 ------------------EIEELRSKLLESEAMNESLRRSLSRLSSRSVYPSSHPSAPSIGSSPS 530

  Fly   555 LYQDQQAALKEQLSQEMVNSSYVSQRLALNSSKSIEMLKEMCAQSLQDQTNLHNKLIGEVMKISD 619
            :  ..:|.:.:.:.|..::...:.::......|..|  ||   :.|:.:..||.:..||  |..:
Zfish   531 V--SMEAEMTDVIRQAKLDVERLKKKERNQRRKRPE--KE---KGLKKRAKLHPEESGE--KSEN 586

  Fly   620 QHSQAFVAKLMEQMQQQQLLMSKEIQTNLQVIEENNQRHKAMLDSMQEKFATIIDSSLQSVEEHA 684
            ..::|                ::|.:.|.....:|......|....::...   :|.....||..
Zfish   587 GLNRA----------------NEERRENGDGDSDNEPEEDGMYPLQEDDHG---ESGCDEEEEEE 632

  Fly   685 KQMHKKLEQLGAMSL----PDAEELQNLQEELANERALAQQEDALLESMMMQMEQIKNLRSKNSI 745
            ::..::.|.....||    .|.:|..|||.:||:.....:.:..|::.:.....::..|:|:...
Zfish   633 EETREEEEFDSDESLVDSDSDTDEKVNLQADLADLTCEIEIKQRLIDELENSQRRLLTLKSQYEE 697

  Fly   746 SMSVHLNKMEESRLTRNHRIDDIKSGIQDYQKLGIEASQSAQAELTSQMEAGMLCLDQGVANCSM 810
            .:.:..||:.:::|.|:..:.::.| :::|.:......:|...:...:|...:|.|.......:.
Zfish   698 KLILLQNKIRDTQLERDRVLHNLMS-MENYTEEKASKVKSEYEKRLKEMNRDLLKLQAAQKEHAR 761

  Fly   811 LQVHMKNLNQKYEKETNENVGSVRVHHNQVEIICQESKQQLEAV--QEKTEVNLEQMVDARQQLI 873
            |   :|| ..:||:|..:....|           .|.|:...|:  |.|.|....:|:||::
Zfish   762 L---LKN-QGRYERELKKLQSEV-----------AEMKKAKVALMKQMKEEQQRRRMIDAKR--- 808

  Fly   874 TEDRQRFIGHATVATDLVQESNRQFSE-HAEHQRQQLQICEQELVRFQQSELKTYAPTGTTPSKR 937
                                 ||:.:: ..|.:||:.||...|..:.|| ||.....|....:.|
Zfish   809 ---------------------NREIAQLKKEQRRQEYQIRALESQKRQQ-ELVLRRKTQEVTALR 851

  Fly   938 DFVYPRTLVATSPHQEIVRRYRQELDWSDLDTTATIDECSEGEHDVSMHSVQELSETETIMNSTP 1002
            ....|.:..|..   .:.||.......::|.|:.|....||.|...|:.|:  :....|.:|
Zfish   852 RLAKPLSERAAG---RVSRRLTSVDSGAELSTSTTTTTSSEPESSRSVSSI--IRHWNTKLN--- 908

  Fly  1003 IEPVDGVTVKRGCGTTRNSNSNALKPPVATGGKRSSSLSRSLTPSKTS 1050
                         |....::|:|....:|:..|:......|...|||:
Zfish   909 -------------GYLGETDSHAPAANMASSRKKFQRKGPSSGFSKTA 943

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	157/384 (41%)
		SMC_prok_B	<408..728	CDD:274008	59/333 (18%)
		SMC_prok_B	<651..>921	CDD:274008	52/276 (19%)
		Microtub_bind	923..>1004	CDD:464048	18/80 (23%)
kif21b	XP_073772347.1	None