Protein Alignment Klp61F and KIF15

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: XP_016862373.1
• Gene: KIF15 / 56992
• HGNCID: 17273
• Length: 1411
• Species: Homo sapiens
• Alignment Length: 1145
• Identity: 309/1145 - (26%)
• Similarity: 518/1145 - (45%)
• Gaps: 237/1145 - (20%)

  Fly     8 TSRQPQKKSNQN--IQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHTLDSKL-------TKK 63
            |:.|..:.||:.  |:|:||:||...|.   .||:     |.:.:.......:.|       .|.
Human    13 TNGQSNQPSNEGDAIKVFVRIRPPAERS---GSAD-----GEQNLCLSVLSSTSLRLHSNPEPKT 69

  Fly    64 FTFDRSFGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVG-----NETAELKS 123
            ||||.....::.|..|::.|...::|..::|||.|:|||||||:|||.||:|     |.:..|:
Human    70 FTFDHVADVDTTQESVFATVAKSIVESCMSGYNGTIFAYGQTGSGKTFTMMGPSESDNFSHNLR- 133

  Fly   124 SWEDDSDIGIIPRALSHLFDEL-RMME-----VEYTMRISYLELYNEELCDLLSTDDTTKIRIFD 182
                    |:|||:..:||..: |..|     ..:..:.|::|:|||::.|||  |..:......
Human   134 --------GVIPRSFEYLFSLIDREKEKAGAGKSFLCKCSFIEIYNEQIYDLL--DSASAGLYLR 188

  Fly   183 DSTKKGSVIIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIE 247
            :..|||..::..:|:: |.|..:.|::|..|...|:.|:|.||.:|||||.||:|.:...|...|
Human   189 EHIKKGVFVVGAVEQV-VTSAAEAYQVLSGGWRNRRVASTSMNRESSRSHAVFTITIESMEKSNE 252

  Fly   248 GEDMLKIGKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVD----RAPHVPY 308
            ..: ::...||||||||||. .|..:.:|:|::|..|||:||..||:|||||||    :..||.|
Human   253 IVN-IRTSLLNLVDLAGSER-QKDTHAEGMRLKEAGNINRSLSCLGQVITALVDVGNGKQRHVCY 315

  Fly   309 RESKLTRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLK 373
            |:||||.||::||||..||:|||.:.||.:...||||||.:|.|||.|:||..||:. |:..| .
Human   316 RDSKLTFLLRDSLGGNAKTAIIANVHPGSRCFGETLSTLNFAQRAKLIKNKAVVNED-TQGNV-S 378

  Fly   374 EYTEEIDKLKRDL------------MAARDKNGI-YLAEETYGEITL---KLESQNRELNEKMLL 422
            :...|:.:||..|            ...|||... |:  |.:.|..|   |.|.:.:.|.||
Human   379 QLQAEVKRLKEQLAELASGQTPPESFLTRDKKKTNYM--EYFQEAMLFFKKSEQEKKSLIEK--- 438

  Fly   423 LKALKDELQNKEKIFSEVSMSLVEKTQELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEKKELVA 487
            :..|:|....|||......|.:..:..::.:.|:....::|..|             .|:::.:.
Human   439 VTQLEDLTLKKEKFIQSNKMIVKFREDQIIRLEKLHKESRGGFL-------------PEEQDRLL 490

  Fly   488 SHMKTE-QVLTTQAQEILAAADLATDDTHQLHGTIERRRELDEKIRRSCD---QFKDRMQDNLEM 548
            |.::.| |.|..|.:.....|..|.:: |.|... .||..|.|.::|:.:   |...:::.....
Human   491 SELRNEIQTLREQIEHHPRVAKYAMEN-HSLREE-NRRLRLLEPVKRAQEMDAQTIAKLEKAFSE 553

  Fly   549 IGGSLNLYQDQQA----ALKEQLSQEMVNSSYVSQRLALNSSKSIEMLKEMCAQSLQDQTNLHNK 609
            |.|.....::||.    |.||..             |..|:.|    ||   ||.||.||.|:|
Human   554 ISGMEKSDKNQQGFSPKAQKEPC-------------LFANTEK----LK---AQLLQIQTELNN- 597

  Fly   610 LIGEVMKISDQHSQAFVAKLMEQMQQQQLLMSKEIQT------NLQVI---------EENNQRHK 659
                    |.|..:.|    .|..:::||.:..|:|:      ||:.:         :|.:|.:|
Human   598 --------SKQEYEEF----KELTRKRQLELESELQSLQKANLNLENLLEATKACKRQEVSQLNK 650

  Fly   660 AMLDSMQEKFATIIDSSLQSVEE-------------HAKQMHKK--------LEQLGAMSLPDAE 703
            ...::::.|....|.:.|.::|.             .|.|:|.:        :...|::...::.
Human   651 IHAETLKLKNVMWIYNDLFNLENAGFFPIQIITTPTKAYQLHSRPVPKLSPEMGSFGSLYTQNSS 715

  Fly   704 ELQN--LQEEL---ANERALAQQEDALLESMMMQMEQIKNLRSK------NSISMSVHLNKMEE- 756
            .|.|  |.|.:   .||:|.    :|:.|.:....||:..|::|      .::.:..|::|:|.
Human   716 ILDNDILNEPVPPEMNEQAF----EAISEELRTVQEQMSALQAKLDEEEHKNLKLQQHVDKLEHH 776

  Fly   757 ----SRLTRNHRIDDIKSGIQDYQKLGI-----EASQSAQAELTSQMEAGMLCLDQGVANCSMLQ 812
                ..|..:.|||..|...:...:|.:     :.:|:....|.|::....:.|.......|.::
Human   777 STQMQELFSSERIDWTKQQEELLSQLNVLEKQLQETQTKNDFLKSEVHDLRVVLHSADKELSSVK 841

  Fly   813 VHMKNLNQKYEKETNENVGSVRVHHNQVEI--ICQESKQQLEA---VQEKTEVNLEQMVDARQQL 872
            :...:.....|||.|:.  |.|..|.|:::  :..|:::.||:   :|:..: ||::::......
Human   842 LEYSSFKTNQEKEFNKL--SERHMHVQLQLDNLRLENEKLLESKACLQDSYD-NLQEIMKFEIDQ 903

  Fly   873 ITEDRQRF-IGHATVATDL----------VQESNR---QFSEHAEHQ-----------RQQLQ-- 910
            ::.:.|.| ..:.|:.:||          .:.:|:   ||.|..|:.           ||:.|
Human   904 LSRNLQNFKKENETLKSDLNNLMELLEAEKERNNKLSLQFEEDKENSSKEILKVLEAVRQEKQKE 968

  Fly   911 --ICEQELVRFQQSE---LKTYAPTGTTPSKRDFVYPRTLVATSPHQEIVRRYRQELDWSDLDTT 970
              .|||::.:.|:.|   |.|.....:....||  ..:.:||...:|      .|||..|..:.|
Human   969 TAKCEQQMAKVQKLEESLLATEKVISSLEKSRD--SDKKVVADLMNQ------IQELRTSVCEKT 1025

  Fly   971 ATIDECSEGEHDVSM---HSVQELSETETIMNSTPIEPVD 1007
            .|||...:...|::.   .::.:..|:..::....::.:|
Human  1026 ETIDTLKQELKDINCKYNSALVDREESRVLIKKQEVDILD 1065

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	145/371 (39%)
		SMC_prok_B	<408..728	CDD:274008	79/368 (21%)
		SMC_prok_B	<651..>921	CDD:274008	68/354 (19%)
		Microtub_bind	923..>1004	CDD:464048	18/86 (21%)
KIF15	XP_016862373.1	KISc_KLP2_like	25..373	CDD:276824	144/370 (39%)
		SMC_N	<371..643	CDD:481474	73/326 (22%)
		SMC_prok_B	<579..1362	CDD:274008	110/522 (21%)