Protein Alignment Klp61F and kif14

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: XP_005170522.2
• Gene: kif14 / 562052
• ZFINID: ZDB-GENE-030131-5759
• Length: 1506
• Species: Danio rerio
• Alignment Length: 1292
• Identity: 312/1292 - (24%)
• Similarity: 523/1292 - (40%)
• Gaps: 355/1292 - (27%)

  Fly    11 QPQKKSNQNIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHTLDSKLTKKFTFDRSF----- 70
            |..|..|..:.|.|||||.:|||:..::.:|: .:..::.:.:|. |:|.|.|||||.||
Zfish   227 QELKMENSAVTVAVRVRPFSSREKNEKACQVI-FMENQDTLVQHP-DTKQTHKFTFDFSFCSINE 289

  Fly    71 --GPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMV--GNETAELKSSWEDDSDI 131
              ...|.|..:|..:..||:|...:|:|..:|||||||:||::||:  |.||
Zfish   290 ADASFSSQQLIYEKLARPLLERAFDGFNTCLFAYGQTGSGKSYTMMGFGEET------------- 341

  Fly   132 GIIPRALSHLFDEL---RMMEVEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSVIIQ 193
            |:|||....||..|   ...|:...:.:||.|:|||::.|||...|       :.:.||..:.::
Zfish   342 GVIPRFCEELFSRLARSETKEMSCHLEMSYFEVYNEKIHDLLVAKD-------EQNQKKMPLRVR 399

  Fly   194 GLEEIPVH-------------SKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVV-HIREN 244
               |.||:             |..|:...||.|.::|.||.|.||.:|||||:||::|: ..:..
Zfish   400 ---EHPVYGPYVADLSTNVVSSYSDIKTWLELGNKQRATAATGMNDKSSRSHSVFTLVMTQTKTE 461

  Fly   245 GIEGE--DMLKIGKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVDRAP--- 304
            .:|.|  |.....::|||||||||..:.| ...|.|:||..:||:||||||:||::|.:::.
Zfish   462 FVEEEEHDHCITSRINLVDLAGSERCTSA-QTSGDRLREGASINKSLLTLGKVISSLSEQSQSRK 525

  Fly   305 --HVPYRESKLTRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLT 367
              ..|||||.||.||:|||||.:||::|||:||...::||:||||.||.:|:.|.|..:||:. |
Zfish   526 KVFTPYRESVLTWLLKESLGGNSKTAMIATLSPAASNMEESLSTLRYAQQARMIINIAKVNED-T 589

  Fly   368 KKTVLKEYTEEIDKLKRDLMAAR--DKNGIYLAEETYGEITLKLESQNRELNE-----KMLLLKA 425
            ...::::...|::||:...|:::  :...:.|.::....:..||..|..|:.|     |..|.:|
Zfish   590 NAKLIRDLKAEVEKLRAAQMSSQGVEPEKMRLFQQEIAALKNKLCQQEHEMAEAHRTWKEKLEEA 654

  Fly   426 LK------DELQ------------------NKEKIFSEVSMSLVEKTQ----ELKKTEENLLNTK 462
            .:      .|||                  |::...||:.:.::::.|    :||....:.:...
Zfish   655 ERRKREEAKELQRAGVTFKVDNRLPNLVNLNEDPQLSEMLLYMIKEGQTKVGKLKSESAHDIQLS 719

  Fly   463 GTLLLTKK-VLTKTKRRYKEK-----KELVASHMKTEQVLTTQAQEILAAADLATDDTHQLHGTI 521
            |.|:..:. |::..|.....|     |..|..|:.:|..:......::...|      |...  .
Zfish   720 GALIADQHCVISSVKGTVSIKPMPNAKTFVNGHLVSECTVLHHGDRVILGGD------HYFR--F 776

  Fly   522 ERRRELDEKIRRSC----DQFKDRMQDNLEMIGGSLNLYQDQQAALKEQLSQEMVNSSYVSQRLA 582
            ....|:....|.||    |..||......|::..       |:|.|:.::.:..:.:..
Zfish   777 NHPAEVQSGKRASCWSSGDGHKDFEFAKNELLSA-------QRAQLEAEIQEARLKAKE------ 828

  Fly   583 LNSSKSIEMLKEMCAQSLQDQTNLHN----------KLIGEVMKISDQHSQAFVAKLMEQMQQQQ 637
             ...:.|::.|||..:.|.:|.:|:.          |...|..:..:.|.|. .|..:||:|..:
Zfish   829 -EMMQGIQVAKEMAQKELSEQKSLYEIKIRALERELKEESERKREQELHKQR-AASQIEQLQSVK 891

  Fly   638 LLMSKEIQTN---LQVIEENNQRHKAMLDSMQEKFATIIDSSLQSVEEHAKQMHK----KLEQLG 695
            .|:.||:.::   ||:..:..::..|..|....|....:::..:.:.|...|:..    |:.|..
Zfish   892 TLLEKEVSSHKRRLQMEAQATRQAMADHDVRHAKIVAALEAEKRKIAEDLAQIEMKRALKVTQTP 956

  Fly   696 AMSLP--DA-------EELQNLQEELANERALAQQE--DALLESMMMQME-QIKNLRSKNSISMS 748
            .|::|  ||       ||...:..:|......::.|  |..:|....|:: |::|  :|..||..
Zfish   957 KMAIPQWDAMKLSLMIEEANKISGKLRKHTVFSRHEAADKEVEGGDAQLQVQVQN--TKLGISTF 1019

  Fly   749 VHLNKMEESRLTRNHRI---------DDIKSGIQDYQKLGIEASQSAQA---------------- 788
            ..|.|. :|.|.....|         ||:.....|..:..:.||.|..:
Zfish  1020 WSLEKF-QSNLAAMREIEQGESASKDDDVFYDPNDEWEPDLSASSSTSSFSRRRSRSLLKSRRIS 1083

  Fly   789 --------------ELTSQMEAGM------------------LCLD---QGVA---NC------- 808
                          ..|.....|:                  :|.|   ..||   :|
Zfish  1084 GRLYEIRVHPIQSLHCTPSQSTGLMNKPPSLHSSTSDSALPGICKDLIGSAVARLRSCQSADESE 1148

  Fly   809 --------SMLQVH--MKNLNQKYE---KETNENV------------------------------ 830
                    .:|.||  ::::...||   .::.||:
Zfish  1149 SLADKLTLDLLSVHRAVRSITDLYEDLDDDSEENLFACSTEAQTHLVKATSAVERAVFITMHWVS 1213

  Fly   831 ----GSVRVHHNQVEIICQESKQQLEAVQEKTEVNLEQMVDARQQLITEDRQRF----------I 881
                ||:.|...     .:|.|.:::.:....::.::........::||.|:|.          |
Zfish  1214 SITFGSITVSQR-----AEELKMEVKKIGGYLQLLIQGCDSEISSMVTEARKRVAECINAVFKTI 1273

  Fly   882 GH--ATVATDLVQESNRQFSEHAEHQRQQLQICEQELVRFQQS-------------ELKTYAPTG 931
            |.  |...|||  ..|.|.||..::  :.:..|.|:.:|  ||             |:...:.||
Zfish  1274 GFLAAVNGTDL--HLNEQNSETIDN--RSVVDCLQDGMR--QSVKDLLSVGLLVTEEMLQVSHTG 1332

  Fly   932 TTPSKRDFVYPRTLVATSPHQEIVRRYRQEL-----DWSDLDTTATIDECSEGEHDVSMHSVQEL 991
            :|            :..|...::.|..:..|     ..||......:|..|...:|:...:.:.|
Zfish  1333 ST------------LQISKWMDVARSLQNYLRCCLSKSSDSSENHCVDYESSNLYDIQSTTTKLL 1385

  Fly   992 SETETIMNSTPIEPVDGVTVKRGCGTTRNSNSNALKPPVATGGKRS-SSLSRSLTPS 1047
            ...:.|.:                  ..:|.|..||      |:|| :|||.::..|
Zfish  1386 KLNQAIKD------------------LHSSLSRFLK------GRRSDTSLSEAIQSS 1418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	148/380 (39%)
		SMC_prok_B	<408..728	CDD:274008	75/390 (19%)
		SMC_prok_B	<651..>921	CDD:274008	70/414 (17%)
		Microtub_bind	923..>1004	CDD:464048	14/85 (16%)
kif14	XP_005170522.2	None