Protein Alignment Klp61F and kif22

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: NP_001107063.1
• Gene: kif22 / 561788
• ZFINID: ZDB-GENE-080204-34
• Length: 634
• Species: Danio rerio
• Alignment Length: 695
• Identity: 197/695 - (28%)
• Similarity: 326/695 - (46%)
• Gaps: 142/695 - (20%)

  Fly    15 KSNQNIQVYVRVRPL------NSRERCIRSAEVVDVVGPREVVTRHTLDSKLTKKFTFDRSFGPE 73
            |....::|.||:||.      .|...|:|.      :||:::...:..::..|.::.||...|.|
Zfish    15 KRTSRVRVAVRLRPYMDKQDEKSEGSCVRG------LGPQKLEIINWRNATETLQYQFDVFHGEE 73

  Fly    74 SKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGIIPRAL 138
            :.|.:|:...|.|::..:|||.|.:|||||.||.||||||:|::           ...|:||||:
Zfish    74 TTQQEVFLTSVKPILPHILNGQNASVFAYGPTGAGKTHTMLGSQ-----------EQPGVIPRAV 127

  Fly   139 SHLFDELRMMEV-----EYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSVIIQGLEEI 198
            ..:|:.:...:.     ||::.:||||:|||::.|||| ..:..:.|.:|  |..:::|.||...
Zfish   128 KEVFNLVGAQKKEQDGWEYSIGMSYLEIYNEKVLDLLS-PGSQDLPIRED--KDRNILIPGLTHT 189

  Fly   199 PVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIGKLNLVDLA 263
            |:.|..|...........|.||:|.:|.:|||||.:..|.|...:.|.....  :.|||.|||||
Zfish   190 PLSSFADFDTHFIPASLNRTTASTKLNQRSSRSHAILLIKVVKSQRGPPHRQ--QTGKLYLVDLA 252

  Fly   264 GSENVSKAGNEKGIRVRETVNINQSLLTLGRVITAL-VDRAPHVPYRESKLTRLLQESLGGRTKT 327
            |||:..:.||: |||::|:..||.||.||.:|:.|| ......||||:||||||||:||||...:
Zfish   253 GSEDNRRTGNQ-GIRLKESGAINLSLFTLSKVVDALNTGAGGRVPYRDSKLTRLLQDSLGGSAHS 316

  Fly   328 SIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVL--KEYTEE------------ 378
            .:|..|:|.:|...:|.|.|.:|.::|.|.|:|.|.:.:...|:.  |...||
Zfish   317 VMITNIAPEYKYYFDTFSALNFAAKSKQIVNRPFVRETVLAPTIAPGKRTREEQEAGGSGEPQNK 381

  Fly   379 --------------------------IDK---LKRDLMAARDKNGIYLAEETYGEITLKLESQNR 414
                                      :|:   |::.:|.:.::..:.|         ||..:|:|
Zfish   382 RSKEGKKAEHSPSPPLHPQSSPDSSVLDRLLALEKMMMGSAERERLNL---------LKTVAQSR 437

  Fly   415 ELNEKMLLLKALKDELQNKEKIFSEVSMSLVEKTQELKKTEENLLNTKGTLLLTKKVLTKTKRRY 479
               :::.:||..:.||::|..:|::      :|....|::::.||.......|.:|..|..|.|
Zfish   438 ---KEIQMLKEKQKELEDKANMFNK------QKETTEKESKDALLFKTDLPPLHRKQSTAAKPR- 492

  Fly   480 KEKKELVASHMKTEQVLTTQAQEILAAADLATDDTHQLHGTIERRRELDEKIRRSCDQFKDRMQD 544
              |::.|.:.::..||...|...::....          .|:.:::.:..::   |        |
Zfish   493 --KQQAVVTPLQVSQVQPLQQCAVVCKPS----------QTLVKKKRVQTEV---C--------D 534

  Fly   545 NLEMIGGSLNLYQD------QQAALKEQLSQEMVNSSYVSQRLALNSSKSIEMLKEMCAQSLQDQ 603
            ..|.||..|...:|      ...||.||..::::.:        |||..    |||:  :|||..
Zfish   535 GKENIGVDLPPVEDVNWESRLDPALLEQSRKKILQT--------LNSGS----LKEL--KSLQQI 585

  Fly   604 TNLHNKLIGEVMKISDQHSQAFVAKLMEQMQQQQLLMSKEIQTNL 648
            .:...|||....:|:...:|....|.:|.:..::  .|..|:.|:
Zfish   586 GDKKAKLIMGWREINGDFTQVEDLKKIEGVTVKR--FSSFIKANI 628

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	133/359 (37%)
		SMC_prok_B	<408..728	CDD:274008	54/247 (22%)
		SMC_prok_B	<651..>921	CDD:274008
		Microtub_bind	923..>1004	CDD:464048
kif22	NP_001107063.1	KISc_KID_like	19..343	CDD:276827	128/346 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	357..406		4/48 (8%)
		GPS2_interact	393..468	CDD:464868	16/92 (17%)
		ComEA	571..620	CDD:441164	16/56 (29%)