DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp61F and kif17

DIOPT Version :9

Sequence 1:	NP_476818.1	Gene:	Klp61F / 38135	FlyBaseID:	FBgn0004378	Length:	1066	Species:	Drosophila melanogaster
Sequence 2:	NP_001373250.1	Gene:	kif17 / 557863	ZFINID:	ZDB-GENE-080724-12	Length:	823	Species:	Danio rerio

Alignment Length:	877	Identity:	251/877 - (28%)
Similarity:	418/877 - (47%)	Gaps:	181/877 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SNQNIQVYVRVRPLNSRERCIRSAEVVDVVGPR-EVVTRHTLDS-KLTKKFTFDRSFGPESKQCD 78
            ::::::|.||.||||:||:.:....||.|.... :...:...|: :..|:||||.::.......:
Zfish     2 ASESVKVVVRCRPLNNREKAMNCKIVVSVDSTHCQCFIKKPGDTEEPPKQFTFDGTYYINHSTEE 66

  Fly    79 VYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGIIPRALSHLFD 143
            ||:.:..||:|.|..|||.|:|||||||:||:.||.|..        :..|..||||||..|:|:
Zfish    67 VYNEIAYPLVEGVTEGYNGTIFAYGQTGSGKSFTMQGVP--------DPPSQRGIIPRAFEHIFE 123

  Fly   144 ELRMME-VEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSVIIQGLEEIPVHSKDDVY 207
            .::..| .::.:|.||||:|.||:.|||..|...|:.: .:..::| |.::.|....|||..:..
Zfish   124 TIQCAENTKFLVRASYLEIYKEEIRDLLGKDIKQKMEL-KEHPERG-VYVRDLTMQTVHSVGECE 186

  Fly   208 KLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIGKLNLVDLAGSENVSKAG 272
            ::::.|...|....||||..|||||::|:|.:.|......|::.|:.||||||||||||..||.|
Zfish   187 RVMDLGWRNRSVGYTLMNKDSSRSHSIFTIHLEICSIDTAGDEHLRAGKLNLVDLAGSERQSKTG 251

  Fly   273 NEKGIRVRETVNINQSLLTLGRVITALVD-RAPHVPYRESKLTRLLQESLGGRTKTSIIATISPG 336
             ..|.|::|...||.||..||.||:|||| |:.::|||:||||||||:||||.|:|.::|.:||.
Zfish   252 -ATGDRLQEATKINLSLSALGNVISALVDGRSKYIPYRDSKLTRLLQDSLGGNTRTLMVACLSPA 315

  Fly   337 HKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLKRDLMAARDKNG---IYLA 398
            ..:.||::|||.||:|||:|||:|.:|:. .|..:|:||.|||.|| |.|::.:..:|   .:||
Zfish   316 DNNYEESISTLRYANRAKSIQNRPRINED-PKDALLREYQEEIKKL-RALISGQLGSGNLSSFLA 378

  Fly   399 EETYGEI----------TLKLESQNRELNE----KMLLLKALKD-ELQNKEKIFSEVS---MSLV 445
            .:..||.          |.:.|::..::.|    |:..|:|..| |.::|.|:..:::   .|..
Zfish   379 GQKSGEASAVVSRPQSNTSESEAEKDKIKEEYEKKLARLQAEYDAEQESKVKLQEDIAALRTSYE 443

  Fly   446 EKTQELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEKKELVASHMKTEQVLTTQAQEILAAADLA 510
            .:...|:::..:..:|.|.:.|         :::||           |.:..:.|.:..|..|.:
Zfish   444 TRLSSLERSRGSRTHTTGGVHL---------QQHKE-----------EPITASAASQEQAKIDHS 488

  Fly   511 TDDTHQLHGTIERRRELDEKIRRSCDQFKDRMQDNLEMIGGSLNLYQDQQAALK--EQLSQEMVN 573
            ..:        ||...:|..::.:.......:...:..|.|.|    ||:.||:  :||.||.|.
Zfish   489 ESE--------ERPSSVDATVKGAASGESQILDSVVVDIPGQL----DQKLALERLQQLEQEFVG 541

  Fly   574 SSYVSQRLALNSSKSIEMLKEMCAQ--SLQDQTNLHNKLIGEVMKISDQHSQAFVAKLMEQMQQQ 636
            ...|..          |.||:...|  :|.||   ..|.:.|.:..|.:...:.:..:.:.:|::
Zfish   542 GEQVRN----------EELKQRHKQRKTLADQ---RKKQLIEALNQSSEDGDSVLLNVYDSIQEE 593

  Fly   637 QLLMSKEIQT-------------NLQV---IEENN--------QRHKAMLDSMQEKFATII--DS 675
            ....|:.::.             :||.   :|.|:        :|...:|..:.|:..:::  |.
Zfish   594 VHAKSRHLENTQKKLKAAKLEIRDLQAEFEMERNDYLATIRRLEREGQLLQGILERMVSLVRRDC 658

  Fly   676 SLQSVEEHAKQMHKKL---EQLGAMSLPDA---------------------EELQNLQEELANER 716
            :..:::    ::.|:.   |:.|...|||.                     ...:|...:||:..
Zfish   659 NYSNLD----RLRKEAVWDEEGGTWRLPDVLVQKTTLPAVPPSGVIAPGRLSARRNSASDLADPF 719

  Fly   717 ALAQQEDALLE--------------------SMMMQMEQIKN-LRSKNSISM-SVHLNK------ 753
            ...:::|...|                    |.::..:.:|| :...:|:|. |.|.:.
Zfish   720 VQEEEQDRYKEMLNRSDSEHIATNYFRPKRSSQLLATDSVKNSMNFSSSVSNGSAHQSSSGSGLS 784

  Fly   754 --MEESRLTRNHRIDDIKSGIQDYQKLGIEAS 783
              ..||.|.|..|:          :.||:.||
Zfish   785 ALTVESILPRPFRL----------ESLGVPAS 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	151/351 (43%)
		Kinesin	25..356	CDD:278646	144/334 (43%)
		Microtub_bind	923..>1009	CDD:290642
kif17	NP_001373250.1	Motor_domain	4..335	CDD:419868	146/341 (43%)
kif17	NP_001373250.1	Smc	395..>650	CDD:224117	56/299 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910