DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp61F and kif3a

DIOPT Version :9

Sequence 1:	NP_476818.1	Gene:	Klp61F / 38135	FlyBaseID:	FBgn0004378	Length:	1066	Species:	Drosophila melanogaster
Sequence 2:	NP_001017604.2	Gene:	kif3a / 550267	ZFINID:	ZDB-GENE-050417-71	Length:	701	Species:	Danio rerio

Alignment Length:	768	Identity:	239/768 - (31%)
Similarity:	391/768 - (50%)	Gaps:	115/768 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NTSRQPQK-KSNQNIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHTLD--SKLTKKFTFDR 68
            |...:|:| :.:.|::|.||.||||.:|:.:...:.|.|...|..:|.:.||  |:..|.||||.
Zfish     4 NKLDKPEKLEVSDNVKVVVRCRPLNEKEKIMGHKQSVTVDEIRGTITVNKLDISSEPPKTFTFDT 68

  Fly    69 SFGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVG-NETAELKSSWEDDSDIG 132
            .|||:|||.|||::...|:|:.||.|||.|:|||||||||||.||.| ....||:         |
Zfish    69 VFGPDSKQLDVYNLTARPIIDSVLEGYNGTIFAYGQTGTGKTFTMEGVRAVPELR---------G 124

  Fly   133 IIPRALSHLFDELRMME--VEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSVIIQGL 195
            |||.:.:|:|..:...|  ..:.:|:||||:||||:.|||..|...::.:  .......|.|:.|
Zfish   125 IIPNSFAHVFGHIAKAEGDTRFLVRVSYLEIYNEEVRDLLGKDQMQRLEV--KERPDVGVYIKDL 187

  Fly   196 EEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIGKLNLV 260
            ....|::.||:.:::..|.:.|....|.||..|||||.:|:|.:...|.|::|...:::|||:||
Zfish   188 SGYVVNNADDMDRIMTLGHKNRSVGATNMNEHSSRSHAIFTITIECSEKGVDGNQHVRMGKLHLV 252

  Fly   261 DLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVD-RAPHVPYRESKLTRLLQESLGGR 324
            ||||||...|.| ..|.|::|...||.||.|||.||:|||| ::.|||||.||||||||:||||.
Zfish   253 DLAGSERQGKTG-ATGQRLKEATKINLSLSTLGNVISALVDGKSTHVPYRNSKLTRLLQDSLGGN 316

  Fly   325 TKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLKRDL--- 386
            :||.:.|.|.|...:.:||:|||.||:|||||:||..:|:. .|..:|:::.:||::||:.|
Zfish   317 SKTMMCANIGPADYNYDETISTLRYANRAKNIKNKARINED-PKDALLRQFQKEIEELKKKLEEG 380

  Fly   387 --MAARDKNGIYLAEE----TYGEITLKLESQNRELNEKMLLLKALKDELQNKEKIFSEVSMSLV 445
              ::..|.:|....:|    ..||...|...:.:...:||:.::|..:|  .::.:.:::.|...
Zfish   381 EEISGSDGSGSDDMDEDDVGDGGERRRKRRGRKKVSPDKMVEMQAKIEE--ERKALEAKLDMEEE 443

  Fly   446 EKTQ---ELKKTEENLLNTKGT-LLLTKKVLTKTKRRYKEKKELVASHMKTEQVLTTQAQEILAA 506
            |:.:   ||:|.|::||..:.. .||.:|:....||......:|:|...:.|::|.....|
Zfish   444 ERNKARAELEKREKDLLKAQQEHHLLLEKLSALEKRVIVGGVDLLAKAEEQEKLLEESNNE---- 504

  Fly   507 ADLATDDTHQLHGTIERRRELDEKIRRSCDQFKDRMQDNLEMIGGSLNLYQDQQAALKEQLSQEM 571
                          :|.||:..|::||   :.:::.|:.|::        :::..:|:|:
Zfish   505 --------------LEERRKRAEQLRR---ELEEKEQERLDI--------EEKYTSLQEE----- 539

  Fly   572 VNSSYVSQRLALNSSKSIEMLKEMCAQSLQDQTNLHNKLIGEVMKISDQHSQAFVAKLMEQMQQQ 636
                      |...:|.::.:..|...:..:..:|..:...|:..:.:.     :.:|..:::.|
Zfish   540 ----------AQGKTKKLKKVWTMLMAAKSEMADLQQEHHREIEGLLEN-----IRQLSRELRLQ 589

  Fly   637 QLLMSKEIQTNLQVIEE---------------------NNQRHKAMLDSMQEKFATIIDSS---L 677
            .|::...|....|.:.|                     ||.|.:..:...:||....:|.|   |
Zfish   590 MLIIDNFIPQEYQEMIENYVHWNEDIGEWQLKCVAYTGNNMRKQTPVSDKKEKDPFEVDLSHVYL 654

  Fly   678 QSVEEHAKQMHKKLEQLGAMSLPDAEELQNLQEELANERALAQQEDALLESMM 730
            ...||..:|...|||:      |...: ..........|..:.:.:|::||::
Zfish   655 AYTEESMRQSLMKLER------PRTSK-NGKSRPKTGRRKRSSKPEAVIESLL 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	161/353 (46%)
		Kinesin	25..356	CDD:278646	153/336 (46%)
		Microtub_bind	923..>1009	CDD:290642
kif3a	NP_001017604.2	KISc_KIF3	16..348	CDD:276822	156/343 (45%)
kif3a	NP_001017604.2	Kinesin	23..348	CDD:278646	153/336 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4221
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940