Protein Alignment Klp61F and KIF1A

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: XP_047300774.1
• Gene: KIF1A / 547
• HGNCID: 888
• Length: 1825
• Species: Homo sapiens
• Alignment Length: 1103
• Identity: 267/1103 - (24%)
• Similarity: 444/1103 - (40%)
• Gaps: 259/1103 - (23%)

  Fly    19 NIQVYVRVRPLNSRE-----RCI--RSAEVVDVVGPREVVTRHTLDSKLTKKFTFDRSF----GP 72
            :::|.|||||.||||     :||  .|.....:|.|::       ..:..|.|:||.|:    .|
Human     5 SVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQ-------PKETPKSFSFDYSYWSHTSP 62

  Fly    73 E----SKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGI 133
            |    :.|..||..:...:::....|||..:|||||||.||::||:|.:        |.|.. ||
Human    63 EDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQ--------EKDQQ-GI 118

  Fly   134 IPRALSHLFDELRMM---EVEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSVIIQGL 195
            ||:....||..:...   .:.|::.:||:|:|.|.:.|||:..:...:|:.:....  ...::.|
Human   119 IPQLCEDLFSRINDTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLL--GPYVEDL 181

  Fly   196 EEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVV----HIRENGIEGEDMLKIGK 256
            .::.|.|.:|:..|::.|.:.|..|.|.||..|||||.||:|:.    |..|..|..|   |:.|
Human   182 SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTE---KVSK 243

  Fly   257 LNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITAL--VDRAPH----------VPYR 309
            ::||||||||.....| .||.|::|..|||:||.|||:||:||  :|..|:          :|||
Human   244 ISLVDLAGSERADSTG-AKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKKTDFIPYR 307

  Fly   310 ESKLTRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKE 374
            :|.||.||:|:|||.::|:::|.:||...:.:||||||.||.|||.|:....:|:....| :::|
Human   308 DSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAVINEDPNNK-LIRE 371

  Fly   375 YTEEIDKLKRDLMAARDKNGIYLAEETYGEITLKLESQNRELNEKMLLLKALKDELQNKEKIFSE 439
            ..:|:.:| |||:.|:....|.......|......:.:|..||....:.:| .|.|.........
Human   372 LKDEVTRL-RDLLYAQGLGDITDTNTVPGGPKYVSDLENNNLNRGGTVNEA-PDPLSTVTNALVG 434

  Fly   440 VSMS-----LVEKTQELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEKKELVASHMKTEQVLTTQ 499
            :|.|     |..:...:....|.:|...|:        .:...|.||.::::|
Human   435 MSPSSSLSALSSRAASVSSLHERILFAPGS--------EEAIERLKETEKIIA------------ 479

  Fly   500 AQEILAAADLATDDTHQLHGTIERRRELDEKIRRSCDQFKDRMQDNLEMIGGSLNLYQDQQAALK 564
                            :|:.|.|.:....|.||...:.....|...:...||:|.::..::....
Human   480 ----------------ELNETWEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHL 528

  Fly   565 EQLSQEMVNSSYVSQRLALNSSKSIEMLKEMCAQSLQDQTNLHNKLIGEVMKISDQH-------- 621
            ..|:::.:    :|:.|.......|..:.....:..||..     |.|..:|  ::|
Human   529 VNLNEDPL----MSECLLYYIKDGITRVGREDGERRQDIV-----LSGHFIK--EEHCVFRSDSR 582

  Fly   622 --SQAFVAKLMEQMQQQQLLMSKEIQTNLQVIEENNQRHKAMLDSMQEKFATIIDSSLQSVEEHA 684
              |:|.|.  :|..:.....::.:..|...::...|:              .|:..|......|.
Human   583 GGSEAVVT--LEPCEGADTYVNGKKVTEPSILRSGNR--------------IIMGKSHVFRFNHP 631

  Fly   685 KQMHKKLEQLGAMSLPDAEELQNLQEELANERALAQQEDALLESMMMQMEQIKNLRSKNSISMSV 749
            :|..::.|:......| ||.:         :.|.||:|  |||...:.|:|          .|..
Human   632 EQARQERERTPCAETP-AEPV---------DWAFAQRE--LLEKQGIDMKQ----------EMEQ 674

  Fly   750 HLNKMEESRLTRNHRIDDIKSGIQDYQKLGIEASQSAQAELTSQMEAGMLCLDQGVANCSMLQVH 814
            .|.::|:                 .|::              .:.||..|...|.:...|.|:..
Human   675 RLQELED-----------------QYRR--------------EREEATYLLEQQRLDYESKLEAL 708

  Fly   815 MKNLNQKYEKETNENVGSVRVHHNQVEIICQESKQQLEAVQEKTEVNLEQMVDARQQLITEDRQR 879
            .|.::.:|..|.||..              :|.:.:::..:.:.|:.|......:....|..|..
Human   709 QKQMDSRYYPEVNEEE--------------EEPEDEVQWTERECELALWAFRKWKWYQFTSLRDL 759

  Fly   880 FIGHATVATDLVQESNRQFSEHAEHQRQQLQICEQELVRFQQSELKTYAPTGTTPSKRDFVYPRT 944
            ..|:|.    .::|:|....|..:..:.|..:....|......:|   .|......:....:|||
Human   760 LWGNAI----FLKEANAISVELKKKVQFQFVLLTDTLYSPLPPDL---LPPEAAKDRETRPFPRT 817

  Fly   945 LVAT--------SPHQEIVRRYRQELDWSDLDTTATIDECSEGEHDVSMHSVQELSETETIMNST 1001
            :||.        :.|...:.:.||.||                       .::|:.:....:.|:
Human   818 IVAVEVQDQKNGATHYWTLEKLRQRLD-----------------------LMREMYDRAAEVPSS 859

  Fly  1002 PIEPVDGVTVK-----------RGCGTTRNSNSNALKPPVATGGKRSSSLSRSLTPSKT--SP 1051
            .||..|.|...           |..|::..|..|:. |.:.|   ..|....:||||.|  ||
Human   860 VIEDCDNVVTGGDPFYDRFPWFRLVGSSAISGCNSY-PLLNT---CMSERMAALTPSPTFSSP 918

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	139/379 (37%)
		SMC_prok_B	<408..728	CDD:274008	56/334 (17%)
		SMC_prok_B	<651..>921	CDD:274008	45/269 (17%)
		Microtub_bind	923..>1004	CDD:464048	14/88 (16%)
KIF1A	XP_047300774.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	138/377 (37%)
		Kinesin_assoc	358..549	CDD:465047	40/233 (17%)
		FHA_KIF1A	525..639	CDD:438778	20/140 (14%)
		ERM_helical	658..>711	CDD:466641	16/95 (17%)
		KIF1B	839..886	CDD:463574	11/69 (16%)
		DUF3694	1275..1431	CDD:463599
		PH_KIFIA_KIFIB	1706..1808	CDD:269939