Protein Alignment Klp61F and kif7

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: NP_001014816.1
• Gene: kif7 / 544651
• ZFINID: ZDB-GENE-050307-1
• Length: 1363
• Species: Danio rerio
• Alignment Length: 1412
• Identity: 340/1412 - (24%)
• Similarity: 542/1412 - (38%)
• Gaps: 433/1412 - (30%)

  Fly    14 KKSNQNIQVYVRVRP------LNSRERCIRSAEVVDVVGPREVVTRHTLDSKLTKKFTFDRSFGP 72
            |.....:||.|||||      |:|.|.||.|       .|.|  .|.||.:  .:.|..|..|..
Zfish    10 KVEESAVQVAVRVRPLLPKEILHSHESCITS-------DPEE--RRVTLGN--DRHFHCDFVFED 63

  Fly    73 ESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGIIPRA 137
            .|.|.:||:..|.||||...:|:|.||.||||||:|||:| :|..:.   |::.||.. ||||||
Zfish    64 GSTQEEVYTNCVQPLIEAFFHGFNATVSAYGQTGSGKTYT-IGEASI---SAFRDDEQ-GIIPRA 123

  Fly   138 LSHLF---DELRMMEVEYTMRISYLELYNEELCDLLSTDDTTK-IRIFDDSTKKGSVIIQGLEEI 198
            ::.:|   ||..:  :::::|:||:|:|.|...|||..:..:| |.|.:|  ::|:|::.|::|.
Zfish   124 VAEIFKLLDENDL--IDFSVRVSYMEVYKEVFRDLLEVETASKDIHIRED--ERGNVVLCGVKEC 184

  Fly   199 PVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENG---IEGEDMLKIGKLNLV 260
            .|...|:|..|||.||..|.|..|.||..||||||:|::::..|..|   ..|...:...|.:.|
Zfish   185 EVEGLDEVLSLLESGKTARHTGATQMNPHSSRSHTIFTVLMEQRRGGSRAANGSVQILSSKFHFV 249

  Fly   261 DLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVD---RAPHVPYRESKLTRLLQESLG 322
            ||||||.:.|.|| .|.|::|::.||..||.||.||.||.|   :..|:|||:||:||:|::|||
Zfish   250 DLAGSERILKTGN-TGERLKESIQINSGLLVLGNVIGALGDPKRKGTHIPYRDSKITRILKDSLG 313

  Fly   323 GRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVN------------------------ 363
            |..||.:||.|||...|.:|:|:||.||.||:||||:..||
Zfish   314 GNAKTLMIACISPSSSDFDESLNTLNYAKRARNIQNRATVNCRGEPDRIEGLELQIKALRRALEN 378

  Fly   364 -QKLTKKTVLKEYTE------EIDKLKRDLMAARDK----NGIYLAEETYGEITLKLESQNRELN 417
             |:...:.:.:...|      |:|..|....:|..:    :...|..|..||.||. ..|...:.
Zfish   379 RQRSETRIIARSDPEKRLRPFEVDVRKLQAESAHYRTCTDSAYRLLTELQGEGTLN-AGQILRVK 442

  Fly   418 EKMLLLKALKDELQNKEKIFSEVSMSLVEKTQELKKTEENLLNT-------KG-----TLLLTKK 470
            |.:..::..:..|.:...:.|.:..|..|.:..||:.:..|.|.       :|     |..|..:
Zfish   443 EWLCGVEEERSGLTSASGLDSGIESSSTEDSTALKRRQAVLNNQDLVKEDWRGEREDYTSQLQAQ 507

  Fly   471 V-------------LTKTKRRYK-------EKKELVAS--------------HMKTEQVLTTQAQ 501
            :             |.....:||       |:::|:|.              |:| ::..|....
Zfish   508 IQQLEQENTDFLVALEDAMEQYKQQSDKLQEQQDLIAELHSLLAQPGGAGFLHLK-QRPHTAPIN 571

  Fly   502 EILAAADLAT--------------------------------DDTH-QLHGTIERRRELDE---- 529
            .:|...|..|                                |.|| ..|....|:...||
Zfish   572 SLLQTPDRLTPPCDSDVGRSLARQLDVGASVDSSSYSEQTQWDGTHGNTHCESSRKLNRDEDGHM 636

  Fly   530 ----KIRRSCD----------------------------------QFKDR----------MQDNL 546
                ..|:|.:                                  ||..|          :.:::
Zfish   637 QTTRDKRKSINVTWTKKDIAIPQGPFGGTRTALPQTLGLCHPLGMQFNRRTSNSSIGESSVWESV 701

  Fly   547 EMIGGSL----NLYQDQQ--------AALKEQLSQEMVNSSYVSQRLALNSSKSIEMLKEMCAQS 599
            ...||..    .|.|.||        ..:||:|.:|:|.:...:|.:....|:.|..|:....|:
Zfish   702 RGFGGEFCSDRGLLQAQQKIRELSITIRMKEELIKELVKTGKDAQAMNRQYSRKISELEAEAEQA 766

  Fly   600 LQDQTNLHNKLIG-EVM----------------KISDQHSQAFVAKLMEQMQQQQLLMSKEIQTN 647
            ..:.|....:|.. ||.                ||:...|:..|.|..::...|...:|.:.:..
Zfish   767 RVELTEAQKQLQELEVQGGRDAVDRSKAQECRRKIAAAQSKVQVLKQKQRDTAQLASLSAQSERR 831

  Fly   648 LQVIEENNQRHKAMLDSMQEKF------ATIIDSSLQSVEEHAKQMHKKLEQL------------ 694
            :|.:|.|.|..|...|.:|.:.      ...:::.:|..:...|::..|.||.
Zfish   832 VQELERNVQNMKQQQDLLQRRLREESQQKRRLETEMQKGKHRVKELEIKNEQQQKILRIKTEEIA 896

  Fly   695 ------------GAMSLPDAEELQN----LQEELANERALAQQ---EDALLESMMMQMEQI---- 736
                        ..:||.:.::::.    |.||:  |:.|.|:   ||  ||..:.:.|:|
Zfish   897 AFQRQRRSGSNGSVVSLEEQQKIEEQKRWLDEEM--EKVLDQRRGLED--LEGELTKREEILAKK 957

  Fly   737 ------------KNLRSKNSIS-----MSVHLNKMEESRLTRNHRIDDIKSG-IQDYQKLGIEAS 783
                        |.|||..::|     :|..:..:|.....||..   ::|| .||.|::..|.|
Zfish   958 EALLWERSGLESKKLRSSQALSQDLLTLSSRIESLERELTERNGL---LRSGSAQDSQQIRQEIS 1019

  Fly   784 QSAQ---------AELTSQMEAGMLC----------LDQGV----------------------AN 807
            ...|         .||..::..|.|.          ||:.:                      |:
Zfish  1020 NLRQEKELLLKQRVELDDKLRQGNLLSPEEERTLFQLDEAIEALDAAIEYKNEAITQRQRQLRAS 1084

  Fly   808 CSMLQVHMKNLNQKYEKETNENVGSVRVHHNQVEIICQESKQQLEAVQEKTEVNLEQMVDARQQL 872
            .|||.....||..|.   |..:....|.      ::|:...:.:...:|:..:   ||..|..:|
Zfish  1085 GSMLTQWEMNLMAKL---TYLSASETRA------LLCKYFDKVVSLREEERRL---QMALAELEL 1137

  Fly   873 ITEDRQRFIGHATVATDLVQ-ESNRQFS-EHAEHQRQ---QLQICEQELVRFQQSELKTYAPTGT 932
            ..|::|..:|....|.:..| |::|:.: :..||:|.   .||.|.:::.......|:.|
Zfish  1138 RVEEQQNLVGWLEAALERQQLEADRRLTQQQKEHERNIQLLLQQCREQMDEGLAGRLRQY----- 1197

  Fly   933 TPSKRDFVYPRTLVATSPHQEIVRRYRQELDWSDL--------------DTTATIDECS------ 977
                               :.::....:||::..:              ....|.::|.
Zfish  1198 -------------------EGLIHNLSKELNFCKIANQELNIKLREMCGPVNLTGEQCKGLNCDS 1243

  Fly   978 ---EGEHDVSMHSVQELSETETIMNSTP--IEPVDG---VTVKRGCGTTRNS------------- 1021
               .|........|:.:.:.|.:..|..  .|||:.   .|.:|....|.:.
Zfish  1244 LLLAGAQSRVAEDVKPIIDAERVQKSREEMREPVNAPLPATWRRSSLPTEDQYTMEELRQRAACE 1308

  Fly  1022 --NSNALKPPVATGGKRSSSLSRSLTPSKTSPRGSPAFVRHNKENVA 1066
              |:..::|     |..|:..|.|.:...|.||..|   |.:..|.|
Zfish  1309 LPNNRIVQP-----GMNSTHWSGSTSLPVTRPRREP---RRSSLNTA 1347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	157/388 (40%)
		SMC_prok_B	<408..728	CDD:274008	87/516 (17%)
		SMC_prok_B	<651..>921	CDD:274008	76/374 (20%)
		Microtub_bind	923..>1004	CDD:464048	10/105 (10%)
kif7	NP_001014816.1	KISc_KIF4	14..348	CDD:276823	152/354 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	603..642		7/38 (18%)
		Smc	<714..>1231	CDD:440809	106/559 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1314..1346		10/39 (26%)