Protein Alignment Klp61F and cmet

DIOPT Version :9

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: NP_524993.3
• Gene: cmet / 53561
• FlyBaseID: FBgn0040232
• Length: 2189
• Species: Drosophila melanogaster
• Alignment Length: 1216
• Identity: 297/1216 - (24%)
• Similarity: 516/1216 - (42%)
• Gaps: 258/1216 - (21%)

  Fly    15 KSNQNIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHTLDSKLTKKFTFDRSFGPESKQCDV 79
            |:..:|||.::|||      |......:..|..|..:  |..||. .:.:.||..|...:...:|
  Fly     4 KNASSIQVCIKVRP------CEPGLTSLWQVKERRSI--HLADSH-AEPYVFDYVFDEGASNQEV 59

  Fly    80 YSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGIIPRALSHLFDE 144
            :..:...::...:.|:|.|:||||||.:|||:||:|           |:.:.|::..|...:|.:
  Fly    60 FDRMAKHIVHACMQGFNGTIFAYGQTSSGKTYTMMG-----------DEQNPGVMVLAAKEIFQQ 113

  Fly   145 LRM-MEVEYTMRISYLELYNEELCDLLS-TDDTTKIRIFDDSTKKGSVIIQ-GLEEIPVHSKDDV 206
            :.. .|.::.:|:.|:|:|||::.|||: .:...||.      :.|:.|:. ..||..:.|:.|:
  Fly   114 ISSETERDFLLRVGYIEIYNEKIYDLLNKKNQDLKIH------ESGNGIVNVNCEECIITSEVDL 172

  Fly   207 YKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIGKLNLVDLAGSENVSKA 271
            .:||..|.:.|....|.||.:|||||.:|.|::..|::....:|.:....||||||||||...:.
  Fly   173 LRLLCLGNKERTVGETNMNERSSRSHAIFKIIIESRKSDHSDDDAVIQSVLNLVDLAGSERADQT 237

  Fly   272 GNEKGIRVRETVNINQSLLTLGRVITALVDRAPH--VPYRESKLTRLLQESLGGRTKTSIIATIS 334
            | .:|.|::|..:||:|||.|..||.:|.:.|.:  ..||:|||||:||.||||...||||.||.
  Fly   238 G-ARGARLKEGGHINKSLLFLSNVIKSLSENADNRFTNYRDSKLTRILQASLGGNAFTSIICTIK 301

  Fly   335 PGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLKRDLMAARDKNGIYLA- 398
            |  ..:||:.|||.:|.|||.|:.||:||:.::..|::|       :|:|::...:||    ||
  Fly   302 P--SIMEESQSTLSFATRAKKIRIKPQVNEMVSDATMMK-------RLEREIKVLKDK----LAE 353

  Fly   399 EETYGEITLKLESQNRELN---EKMLLLKALKDELQNK-EKIFSEVSMSLVEKTQELKKTEENLL 459
            ||...|...|:|...|::.   .|::...:|.|:.|.| .:.:...:.....:..|...||:.:.
  Fly   354 EERKNENQQKVEHLERQIKHDMHKIICGHSLSDKGQQKRRRTWCPTASGSHLELAETGTTEDRID 418

  Fly   460 NTKGTLLLTKKVLTKTKRRYKEKKELVASHMKTEQVLTTQAQEILAAADLATDDTHQLHGTIERR 524
            .......|.|.|...|....|....:            .:...||.:.|:.|          |..
  Fly   419 QFPKVSHLPKPVFFHTSNAGKRWDNI------------PKTINILGSLDIGT----------ESN 461

  Fly   525 RELDEKIRRSCDQFKDRMQDNLEMIGGSLNLYQ--DQQAALKEQLSQEMVNSSYVSQRLALNSSK 587
            ...:|.:...|..|.....|.|:.:   |.:.|  |.....|..|:.:.:.......::..:..|
  Fly   462 SISEEFLPAECIDFGSPRPDVLKPM---LTIRQLPDLPLTPKGPLTTDKIKKEIQDLQMFTSLEK 523

  Fly   588 SIEM-------LKEMCAQSLQDQTNLHNKLIGE------------VMKISDQHSQAFVAKLMEQM 633
            ..|:       |||..|:....:.||..:.:.|            .::..::.:.:.:::|.|::
  Fly   524 HFEVECEEVQGLKEKLAEVTAQRDNLEQESLAEKERYDALEKEVTSLRADNEAANSKISELEEKL 588

  Fly   634 QQ-QQLLMSKEIQTNLQV-IEENNQRHKA--------MLDSMQEKFATI------IDSSLQSVEE 682
            .. :|.:...|::..:.| :|...:.||.        :|.::.||.:||      :|:..:.|..
  Fly   589 STLKQTMRIMEVENQVAVGLEFEFEAHKKSSKLRVDDLLSALLEKESTIESLQKSLDNLTRDVLR 653

  Fly   683 HAKQMH-----KKLEQLGAMSLPD-AEELQNLQEELANERALAQQEDALLE--SMMMQMEQIK-- 737
            ::|:.|     .:.|.:...|:.: .|||:.|..:|.:::...:.:...||  |:..::|.::
  Fly   654 NSKEGHMLSIAPEQEDIAGDSICNKCEELEKLIADLESKKNSCECDQLRLEIVSVRDKLESVESA 718

  Fly   738 -NLRSKNSISMSVHLNKMEESRLTRNH-------RIDDI-------KSGI-----------QDYQ 776
             ||.|...|..:....::.:...|..:       |.|.:       ::||           :.||
  Fly   719 FNLASSEIIQKATDCERLSKELSTSQNAFGQLQERYDALDQQWQAQQAGITTLHEKHEHVQEKYQ 783

  Fly   777 KLGIEASQ-SAQAELTSQMEAGMLCLDQGVANCSMLQVHMKNLNQKYEKETN---------ENVG 831
            ||..|..| .::|...|..|...|..|.     :..|..:.:||::.|:..|         ..|.
  Fly   784 KLQEEYEQLESRARSASSAEFQRLQNDN-----TKFQADIASLNERLEEAQNMLTEVQNSESTVE 843

  Fly   832 SVRVHHNQVEIICQESKQQLEAVQEKTEVNLEQMVDARQQ---LITEDRQRFIGHATVATDLVQE 893
            .:|:.::::....:|.:...|.:|.:.:....|::::.|:   |..|.:||...|       |:|
  Fly   844 KLRIQNHELTAKIKELETNFEEMQREYDCLSNQLMESVQENDALREEIKQRPTSH-------VEE 901

  Fly   894 SNRQ--FSEHAEHQRQQLQICEQ-----ELVRFQQSELKTYAPTG----TTPSKRDFVYP----- 942
            |.|.  .|...:.|:|.:.:..|     |.|  ||.||:.::...    ....|.|...|
  Fly   902 SMRSSGISSDFDEQKQDINLLHQFVQLSESV--QQIELQHHSGISRLFRANQMKLDQSEPGLKLC 964

  Fly   943 -----------RTLVATSP---------HQEIVRRYRQE-LDWSD----LD-------------- 968
                       |...||.|         |:..::|..|| :|..:    ||
  Fly   965 LESAEYIEEDNRQSDATEPICLKGFLKRHRFQIKRLSQEHVDMGEEKRLLDIISQLEQEIEEKSA 1029

  Fly   969 ----TTATIDECSEGEHDVSMHSVQE-LSETETIMNST-----PIEPVDGVTVKRGCGTTRNSNS 1023
                |.|||:|..|     .|.:::. |.|...|:|..     .||.::          .:|:..
  Fly  1030 LMEATEATINEMRE-----QMTNLESALLEKSVIINKVEDYQRQIESLE----------KQNAEM 1079

  Fly  1024 NALKPPVATGGKRSSSLSRSL---TPSKTSPRGSPAFVRHNKENVA 1066
            ..:...:.....|.||:|.||   .|.:.:..|.|......::.||
  Fly  1080 TMVYEELQDRVTRESSMSESLLRVPPDEDTLPGCPTSPSRREQEVA 1125

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	127/352 (36%)
		Kinesin	25..356	CDD:278646	119/335 (36%)
		Microtub_bind	923..>1009	CDD:290642	29/143 (20%)
cmet	NP_524993.3	KISc	8..328	CDD:214526	125/348 (36%)
		Motor_domain	8..321	CDD:277568	122/341 (36%)
		Smc	<680..1449	CDD:224117	99/475 (21%)
		TMPIT	779..>867	CDD:285135	20/92 (22%)
		Smc	1042..1910	CDD:224117	20/99 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437923
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840