Protein Alignment Klp61F and LOC4576148

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: XP_061512564.1
• Gene: LOC4576148 / 4576148
• VectorBaseID: AGAMI1_001728
• Length: 1254
• Species: Anopheles gambiae
• Alignment Length: 1222
• Identity: 289/1222 - (23%)
• Similarity: 500/1222 - (40%)
• Gaps: 295/1222 - (24%)

  Fly    10 RQPQKKSN-------QNIQVYVRVRPLNSRERCIRSAEVVDVV---GPREVVTRHTLDSKLTKKF 64
            |:|.|...       :.::|.||:||::..|:......||:..   .|:.:|......|.:   |
Mosquito    15 REPTKAPGAAAMPGPECVKVAVRIRPMSQSEQARGCQTVVEQAAPGAPQLLVCGGRTPSDV---F 76

  Fly    65 TFDRSFGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDS 129
            ::...|.|.:.|..:|.|.|||::.::..|||.|:.|||||.:|||.||..:...|:      ||
Mosquito    77 SYSYVFPPSTVQSQLYEVAVSPMLHKLFAGYNATILAYGQTSSGKTFTMGTHFAGEV------DS 135

  Fly   130 DIGIIPRALSHLFDELRMM---------EVEYTMRISYLELYNEELCDLLSTD--DTTKIRIFDD 183
            .:|:||||::.:|   |:|         .|:..:..||:|:|.:::.|||:..  .|.:..:...
Mosquito   136 SVGVIPRAINDIF---RLMADGTAEVTAHVDTRVTCSYIEVYQDQVFDLLAEKPAGTERQPVDIR 197

  Fly   184 STKKGSVIIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEG 248
            ....|.:|:|||.|:........:..|.:|...|....|.||..|||||.:|::.:|  ....:.
Mosquito   198 EAVGGDIILQGLTEVAAGGVQSAFDCLARGSLGRVVRATAMNNVSSRSHAIFTLTLH--HTARDD 260

  Fly   249 EDMLKIGKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVDRA-----PHVPY 308
            ..::...|.:||||||||. ||..:..|.|.:|.|.||:.||.||.|||||...|     .|:||
Mosquito   261 PAVVTRSKFHLVDLAGSER-SKKTDTTGDRFKEGVQINKCLLALGNVITALGSSAGAAGKMHIPY 324

  Fly   309 RESKLTRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLK 373
            |.||||||||:||||.:.|.:||.:||...::.||.|||.||:|...|:|||.|||. .::..:|
Mosquito   325 RSSKLTRLLQDSLGGNSYTLMIACVSPADYNLSETYSTLRYANRVCKIKNKPIVNQD-PQQARIK 388

  Fly   374 EYTEEIDKLKRDLMAAR----------DKNGIY-LAEETYGEIT--------------------- 406
            :....:..|:.::|..:          ||:|.: :.:..:..:.
Mosquito   389 QLEAIVQDLRVEVMMLKSGREGCPPTTDKDGTFRVPQPVHSPLVRGLTETQLLRSPRSSEAGSAS 453

  Fly   407 ------LKLESQNR-------------ELNEK--MLLLKALKD-------ELQ------------ 431
                  .||:..||             |::|:  ||..|.|:|       |.|
Mosquito   454 DPSAGYQKLQEANRCLQKQLQATMHELEVHEERSMLAEKLLEDIEQLLGREAQPGEDGLRQELAR 518

  Fly   432 ----NKEKIFSEVSMSLVE---------------------KTQELKKTEENLLNTKGTLLLTKKV 471
                ::::::|..|:|...                     :|:|.::..|  .:|:..:.:..:
Mosquito   519 LLTAHQDEVYSLGSLSAAYGPPLSRMIRPSTAGAGVDDPLRTEEFERKSE--FHTQQQIRIHSE- 580

  Fly   472 LTKTKRRYKEKKELVASHMKTE------QVLTTQAQEILAAADLATDDTHQLHGTI--------- 521
            ||:.||....|:||   |.|.:      |..|::.:..|      |:..|:..|.:
Mosquito   581 LTQLKREIALKEEL---HRKCQGNSAAVQSYTSRREREL------TEQLHEYEGQMRSLEGQLAE 636

  Fly   522 -----------ERRRELDEKIRRSCDQFKDRMQDNLEMIGGSLNLYQDQQAALKEQLSQEMVNSS 575
                       |:|.:|.|:.||...|.:..:.:..:.......|.:     |.|:.::.:...|
Mosquito   637 LNALLENTKASEKRSKLAEERRRKVQQLEAELAEMRQKSARQAKLLK-----LHEKDAERIAGLS 696

  Fly   576 YVSQRLALNSSKSIEMLKEMCAQSLQDQTNLHNKLIGEVMKISDQHSQAFVAKLMEQMQQQQLLM 640
            ...|::.....|.::.|:.. ::|.:.......|.|.: :|..|:..|..:.||......|:.:|
Mosquito   697 SEIQQMKATRVKLLKTLRTE-SESFRQWRASREKEITQ-LKAKDRKQQYQLQKLESTYSMQKRIM 759

  Fly   641 SKEIQTNLQVIEENNQRHKAMLDSMQ--EKFATIIDSSLQSVEEHAKQMHKKLE----------Q 693
            .:::...:||    |:|.||.|:..|  :..|...|.:.....|.|:.:.::||          .
Mosquito   760 QRKMDETIQV----NKRLKATLERQQRSKTAAGARDRAAMRGAEAARWVKQELELICNTVEATVT 820

  Fly   694 LGAMSLPDAEELQNLQEELANERALAQQEDALLESMMMQMEQIK-NLRSKNSISMSVHLNKMEES 757
            |..:....|:|::.: :::..:.|...:..|..:.:...::|.: :|..:|:..:.:.
Mosquito   821 LSVLRAQRAQEVKKI-KQMEGQCAELPEGGAEYQRLRQDIQQCQLDLDYRNAQIVDLQ------- 877

  Fly   758 RLTRNHRIDDIKSGIQDYQKLGIEASQSAQAELTSQMEAGMLCLDQGVANCSMLQVHMKNLNQKY 822
              |:.|.||      .|.|   :.|.....|:|....:|....|:|      ::|.|.:.:..::
Mosquito   878 --TKLHTID------TDSQ---VAAFGEGLAKLPEARDAFQQLLEQ------LVQTHTRLIETRF 925

  Fly   823 EKETNENVGSVRVHHNQVEIICQES-----KQQLEAVQEKTE---VNLEQMVDARQQLITEDRQR 879
            :....:..|.           |||.     :.||||..::..   |.||:..:.:..|:...|
Mosquito   926 QLVDLQATGD-----------CQEEELAQVRAQLEAADQQYREEVVQLEKRYEDKLALLLMQR-- 977

  Fly   880 FIGHATVATDLVQESNRQFSEHAEHQRQQLQICEQELVRFQQ--SELKTYAPTGTTPSKRDFVYP 942
             .|.|..||...........|..|.:.....:.|:.:.|.:|  .||:.|        ||.....
Mosquito   978 -TGGAAAATAAPTNGTGAEGEEVEEEAGTGAVHEEAIRRIEQLRDELELY--------KRSAQML 1033

  Fly   943 RTLVATSPHQEIVRR----------YRQELDWSDLD-----TTATIDECSEGEHD---VSMH--S 987
            |..:..:..:.:.:|          :..|.|...|:     ...|.|:..|.:.|   ..:|  .
Mosquito  1034 REQLDEATKRPVRKRRMPNHLLDPDFNTEFDLEFLEDEYNQVGGTDDDNPELDPDFRGTPLHKRK 1098

  Fly   988 VQELSETETIMNSTPIEPVDGVTVKRGCGTTRNSNSNALKPPVATGGKRSSS 1039
            .|.:|..||:::|                 |..||::.:......||..|.|
Mosquito  1099 KQSMSIRETLLSS-----------------TIQSNASTVGRAATGGGSASCS 1133

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	135/373 (36%)
		SMC_prok_B	<408..728	CDD:274008	78/416 (19%)
		SMC_prok_B	<651..>921	CDD:274008	55/290 (19%)
		Microtub_bind	923..>1004	CDD:464048	20/100 (20%)
LOC4576148	XP_061512564.1	None