Protein Alignment Klp61F and Kif19A

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: NP_996208.1
• Gene: Kif19A / 41717
• FlyBaseID: FBgn0038205
• Length: 750
• Species: Drosophila melanogaster
• Alignment Length: 779
• Identity: 220/779 - (28%)
• Similarity: 334/779 - (42%)
• Gaps: 197/779 - (25%)

  Fly     4 SGGNTSRQ------PQKKSNQNIQVYVRVRP-LNSRERCIRSAEVVDVVGPREVVTRHTL----- 56
            |||:.|.|      .|....:.:.|.||||| :.:.||||            ||::..:|
  Fly    14 SGGSNSSQGRSIATAQPAQEERLVVAVRVRPSMEATERCI------------EVISGGSLLYDDG 66

  Fly    57 DSKLTKKFTFDRSFGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVG------ 115
            .....:::::|..|.....|..||....:||:.:||||.|..|||||.||:||||||:|
  Fly    67 GKSRPRQYSYDHVFRENDSQEQVYKTTTAPLVRDVLNGLNAAVFAYGATGSGKTHTMLGPVPRKK 131

  Fly   116 -------NETAELKSSWEDDSDIGIIPRALSHLFDELRMMEVEYTMR--ISYLELYNEELCDLLS 171
                   ..||...|:.....|||::.||:..:|..:...|. |:.|  |||||:|||.:.|||:
  Fly   132 PQTSDRAPPTASCDSTDVSSQDIGLMVRAIEDIFSHIESAEA-YSCRVSISYLEIYNELIRDLLN 195

  Fly   172 TDDTTKIRIFDDSTKKGSVIIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFS 236
            .....::|   :..:...:.:.||.||...|:.:|..||.||.:.|....|..|..|||||.:.|
  Fly   196 PGGPLELR---EDHRGQRITVAGLSEITTSSRKEVVSLLLKGNKARTMEPTAANQTSSRSHALLS 257

  Fly   237 IVVHIREN-GIEGEDMLKIGKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALV 300
            |:|..|.. |      .|.|:|.|.||||||...|..| :|.|::|..:||:|||.||.||..|.
  Fly   258 IMVQARTPLG------TKQGRLFLTDLAGSERAKKTKN-RGKRLQEGAHINRSLLALGNVINGLS 315

  Fly   301 DRAPHVPYRESKLTRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNK------ 359
            ..|.:|.||:|||||||:|:|.||.||.:||.::|..|..:||.:||.||.||.:|..|
  Fly   316 GGARYVNYRDSKLTRLLKEALSGRCKTVMIAHVAPESKHRDETKNTLVYADRANSITTKLQNSVY 380

  Fly   360 -PEVNQKLTK--KTVLKEYTEEIDKLKRDLMAARDKNGIYLAEE---------TYGEITLKLESQ 412
             .|.....||  ::::.|..:|:.:|:..::..|.::|...|..         |.|
  Fly   381 IDEFKDFPTKHYQSLVSELRDEVSRLRTKMLTERPRSGAAAAAAAAAASGSAGTAG--------- 436

  Fly   413 NRELNEKMLLLKALKDELQNKEKIFSEVSMSLVEKTQELKKTEENLLNTKGTLLLTKKVLTKTKR 477
                                     |......|::..|.:|||...|..:  ::||.|...|.:|
  Fly   437 -------------------------SGAGSEAVQEQDEQRKTELRYLREQ--IVLTFKQQMKLRR 474

  Fly   478 RYKEKKELVASHM--------KTEQVLTTQAQEILAAADLATDDTHQLHGTIERRR---ELD--E 529
            :..|.:    ||:        :...:::.....|....|...||..:..|::..:.   ||.  |
  Fly   475 KLLEAE----SHLLGLELDAERQHMIISHWQGRIGKLYDAMGDDDIESEGSVALKNAWGELAAIE 535

  Fly   530 KIRRSCDQFKDRMQDNLEMIGGSLNLYQDQQAALKEQLSQEMVNSSYVSQRLALNSSKSIEMLKE 594
            |..|...:.::|.:..||..       :.:...|:::|.:.            ::|.:..|:|..
  Fly   536 KETRRYKEIRERTEHELEQC-------RQKGVKLEDELPER------------ISSDEERELLAL 581

  Fly   595 MCAQSLQDQTNLHNKLIGEVMKISDQHSQAFVAKLMEQMQQQQLLMSKEI-QTNLQVIEENNQRH 658
            :|        .:|..   |..|:|              :|.::|....|: :.:||::....||.
  Fly   582 LC--------RVHEL---EADKVS--------------LQAERLARQAELRRRDLQLLRAERQRR 621

  Fly   659 KAMLDSMQEKFATIIDSSLQSVEEHAKQMHKKLEQLGAMSLPDAEELQNLQEELANERALAQQE 722
            ..         ..||.|..:.:||            |.:.|||  ||:.|.       .|.|||
  Fly   622 LC---------EDIISSQRRLIEE------------GNVDLPD--ELRELY-------GLYQQE 655

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	143/376 (38%)
		SMC_prok_B	<408..728	CDD:274008	61/329 (19%)
		SMC_prok_B	<651..>921	CDD:274008	18/72 (25%)
		Microtub_bind	923..>1004	CDD:464048
Kif19A	NP_996208.1	Motor_domain	35..371	CDD:473979	140/358 (39%)
		SMC_prok_B	<393..672	CDD:274008	69/377 (18%)