Protein Alignment Klp61F and kif22

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: XP_031748433.1
• Gene: kif22 / 394855
• XenbaseID: XB-GENE-979888
• Length: 680
• Species: Xenopus tropicalis
• Alignment Length: 719
• Identity: 205/719 - (28%)
• Similarity: 326/719 - (45%)
• Gaps: 160/719 - (22%)

  Fly    11 QPQKKSNQNIQVYVRVRPLNSRE------RCIR-----SAEVVDVVGPREVVTRHTLDSKLTKKF 64
            |.:|.|:..::|.||:||...:|      .|:|     |.|:|:        .|:.|:   |.::
 Frog    23 QHKKPSSARVRVAVRLRPYMEKEDEKAPAACVRGLDSQSLEIVN--------WRNQLE---TMQY 76

  Fly    65 TFDRSFGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDS 129
            .||..:|..:.|.::|...|..::..:|.|.|.:|||||.||.||||||:||           .|
 Frog    77 QFDAFYGDSATQREIYMGSVCHILPHLLIGQNASVFAYGPTGAGKTHTMLGN-----------PS 130

  Fly   130 DIGIIPRALSHLFDELRMM----EVE---YTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKK 187
            ..|:||||:..|....|..    |.|   ||:.:||:|:|.|::.|||...: ..:.|.:|  |.
 Frog   131 QPGVIPRAVRDLLQMTRTAAGGHENENWTYTITMSYVEIYQEKVMDLLEPKN-KDLPIRED--KD 192

  Fly   188 GSVIIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDML 252
            .:::|.|:.:..::|..|..:......:.|..|:|.:|.:|||||.|  :::.::::........
 Frog   193 HNILIPGVTQKTINSFGDFDEHFIPASQNRTVASTKLNDRSSRSHAV--LLIKVQKSQQVSPFRQ 255

  Fly   253 KIGKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVDRAPHVPYRESKLTRLL 317
            ..|||.|:||||||:..:.||: |||::|:..||.||.||.:|:.||....|.:|||:|||||||
 Frog   256 LTGKLYLIDLAGSEDNRRTGNQ-GIRLKESGAINSSLFTLSKVVDALNQGLPRIPYRDSKLTRLL 319

  Fly   318 QESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKP---EVNQKLTKKTVLKEYTEEI 379
            |:||||...:.:||.|:|..|...:||:.|.:|.::|.|.|||   |..|.:.....:|...||.
 Frog   320 QDSLGGTAHSVMIANIAPEQKYYFDTLTALNFAAKSKQIINKPFSQETTQSIAALPAMKRPREEA 384

  Fly   380 D---------KLKRD--------LMAARDKNGIYLA--EETYGEITLKL----------ESQ--N 413
            :         |.|.|        .|.|..|..:.||  :....|..|||          |:|  :
 Frog   385 ETAAGSRQRKKSKTDSTESSPNTSMDAASKRKLNLAALDPAVVERLLKLDKILTEKGMKEAQLLS 449

  Fly   414 RELNEKMLLLKALK------DELQNKEKIFSEVSMSLVEKTQELKKTEENLLNTKGTLLLTKKVL 472
            ....|:|.|||..:      :.|:.|:|   |:....:|....|:|:..:..|     |....|.
 Frog   450 TPKRERMALLKKWEESQMEIERLKEKQK---ELEQKAIEAEARLEKSTNSDCN-----LSDSSVS 506

  Fly   473 TKTKRR-YKEKKELVASHMKTEQVLTTQAQEILAAADLATDDTH---------------QLHGTI 521
            ..|.|. .:.:....|...|..:||..|.:...|...:...:.|               ||..||
 Frog   507 ECTFRAPLRGRNTSTAKAKKVLRVLPMQGEHPGANGGVLATERHVDPESERSETLLGNSQLQSTI 571

  Fly   522 ERRRELDEKIRR---SCDQFKDRMQDNLEMIGGSLNLYQDQQAALKEQLSQEMVNSSYVSQRLAL 583
            |....:.||.::   |||..::  |...|     :|:..|...:.:|::             |.|
 Frog   572 EEGIPVFEKKKKKPVSCDGREN--QPTWE-----VNVRTDLLESGRERI-------------LKL 616

  Fly   584 NSSKSIEMLKEMCAQSLQDQTNLHNKLIGEVMKISDQHSQAFVA--------KLMEQMQQQQLLM 640
            .::.|::.||     |||              ||.|:.::..:.        |.:|.:...:.:.
 Frog   617 LNTGSVKELK-----SLQ--------------KIGDKKAKLIIGWREVNGPFKNVEDLASLEGIS 662

  Fly   641 SKEI 644
            :|::
 Frog   663 AKQV 666

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	131/368 (36%)
		SMC_prok_B	<408..728	CDD:274008	57/282 (20%)
		SMC_prok_B	<651..>921	CDD:274008
		Microtub_bind	923..>1004	CDD:464048
kif22	XP_031748433.1	KISc_KID_like	31..356	CDD:276827	125/352 (36%)
		ComEA	617..666	CDD:441164	12/67 (18%)