DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp61F and Klp64D

DIOPT Version :9

Sequence 1:	NP_476818.1	Gene:	Klp61F / 38135	FlyBaseID:	FBgn0004378	Length:	1066	Species:	Drosophila melanogaster
Sequence 2:	NP_523934.1	Gene:	Klp64D / 38611	FlyBaseID:	FBgn0004380	Length:	677	Species:	Drosophila melanogaster

Alignment Length:	762	Identity:	228/762 - (29%)
Similarity:	366/762 - (48%)	Gaps:	131/762 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PQKKSN-----------QNIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVT---RHTLDSKLTK 62
            ||:::|           :|::|.||.||::..|....:...:.|......:|   .:...::..|
  Fly     2 PQEEANAGTTAQLDDEIENVRVVVRTRPMDKNELSAGALSAISVDKINRAITVMKPNATANEPPK 66

  Fly    63 KFTFDRSFGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGN-ETAELKSSWE 126
            .:.||..|...|.|.|:|.....|::::||.|||.|:.||||||||||:||.|| ::.:.|
  Fly    67 TYYFDNVFDGGSNQMDLYVDTARPIVDKVLEGYNGTILAYGQTGTGKTYTMSGNPDSPQTK---- 127

  Fly   127 DDSDIGIIPRALSHLFDELRMME--VEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGS 189
                 ||||.|.:|:|..:...:  .::.:|:||:|:||||:.|||..|....:.:  .......
  Fly   128 -----GIIPNAFAHIFGHIAKAKENQKFLVRVSYMEIYNEEVRDLLGKDVGKSLEV--KERPDIG 185

  Fly   190 VIIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGE-DMLK 253
            |.::.|....||:.||:..::..|.:.|....|.||.:|||||.:|||.|...|.| ||: ..::
  Fly   186 VFVKDLSGYVVHNADDLENIMRLGNKNRAVGATKMNQESSRSHAIFSITVERSELG-EGDVQHVR 249

  Fly   254 IGKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVD-RAPHVPYRESKLTRLL 317
            :|||.||||||||..||. ...|.|::|...||.||..||.||:|||| ::.|:|||.|||||||
  Fly   250 MGKLQLVDLAGSERQSKT-QASGQRLKEATKINLSLSVLGNVISALVDGKSTHIPYRNSKLTRLL 313

  Fly   318 QESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKL 382
            |:||||.:||.:.|||||...:..||:|||.||.|||||||:..:|:: .|..:|:.:.|||.:|
  Fly   314 QDSLGGNSKTVMCATISPADSNYMETISTLRYASRAKNIQNRMHINEE-PKDALLRHFQEEIARL 377

  Fly   383 KRDLMAARDKNGIYLAEETYGEITLKLESQNRELNEKMLLLKALKDELQNKEKIFSEVS-MSLVE 446
            ::.|     :.|..|.||       ...|:..|        ....|||:...:|..|.| :..||
  Fly   378 RKQL-----EEGDSLEEE-------PPSSEEEE--------DTADDELEAPLEIELESSTIQAVE 422

  Fly   447 KTQELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEKKELVASHMKTEQVLTTQAQEILAAADLAT 511
            |..:.|:.:.:         ..|:.|.|.|..::::.|    |.||||  .|...::::
  Fly   423 KKPKKKREKTD---------AEKEELAKRKNEHQKEIE----HAKTEQ--ETLRNKLVS------ 466

  Fly   512 DDTHQLHGTIERRRELDEKIRRSCDQFKDRMQDN---LEMIGGSLNLYQDQQAALKEQLSQEMVN 573
                           |:.||....:...::.|..   ||.....|..::..:.|||:.|.|:...
  Fly   467 ---------------LEGKILVGGENLLEKAQTQELLLEQSIAELEQHEKSEEALKQTLQQKATE 516

  Fly   574 SSYVSQRLALNSSKSIEMLKEMCAQSLQDQTNLHNKLIGEVMKISDQHSQAFVAKLMEQMQQQQL 638
            ...:.:|.:                :|||.:....|.|..||    |......::|.:|.|:.|
  Fly   517 RIDIEERYS----------------TLQDASTGITKKIHRVM----QMLMGVKSELADQQQEHQ- 560

  Fly   639 LMSKE-IQTNLQVIEENNQRHKAMLDS-MQEKFATIIDSSLQSVEEHAKQMHKKLEQLGAMSLPD 701
             ..|| |..|::.:.......:.:|:| :.:::.::|:......|:..:...|.:...|
  Fly   561 -REKEGIYENIRSLSRELALCELVLNSYVPKEYQSMINQYTHWNEDIGEWQLKCVAYTG------ 618

  Fly   702 AEELQNLQEELANERALAQQEDALLES---MMMQMEQIKN-LRSKNS 744
                .|:::.::..:...::.|.|..|   :....:.:.| :|||::
  Fly   619 ----NNMRKHISAHKTSGKEPDFLDLSHVYLSYNTDGVSNPMRSKSA 661

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	149/366 (41%)
		Kinesin	25..356	CDD:278646	140/338 (41%)
		Microtub_bind	923..>1009	CDD:290642
Klp64D	NP_523934.1	KISc_KIF3	19..352	CDD:276822	143/345 (41%)
		Kinesin	26..352	CDD:278646	140/338 (41%)
		RILP-like	<437..556	CDD:304877	32/165 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437769
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D24620at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4221
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.880