DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp61F and pav

DIOPT Version :9

Sequence 1:	NP_476818.1	Gene:	Klp61F / 38135	FlyBaseID:	FBgn0004378	Length:	1066	Species:	Drosophila melanogaster
Sequence 2:	NP_477025.1	Gene:	pav / 38515	FlyBaseID:	FBgn0011692	Length:	887	Species:	Drosophila melanogaster

Alignment Length:	978	Identity:	217/978 - (22%)
Similarity:	382/978 - (39%)	Gaps:	308/978 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RQPQKKSNQNIQVYVRVRPLNSRERCIRSAEVVD----VVGPREVVTRHTL---DSKLTKKFTFD 67
            |....|:...:.|:.|||||.| :..:.|..|.:    .:.|::.:.:|..   .::...::.|.
  Fly    27 RDTSDKARDPVNVFCRVRPLQS-DADLTSLRVKNSTTIALNPQDQLLQHHKPHNGAQREVQYIFK 90

  Fly    68 RSFGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIG 132
            ..|.|::.|.|||:.|..||:|.:|.|.|..:|.||.||:|||:||.||    |:..       |
  Fly    91 HVFQPDATQQDVYAAVAQPLVENLLKGRNSLLFTYGVTGSGKTYTMTGN----LRHR-------G 144

  Fly   133 IIPRALSHLF---------------DELRMMEV-------------------------------- 150
            |:||.|..||               |:|...|:
  Fly   145 IMPRCLDVLFRTISDYQAKKFVFKPDKLNGFEILSEEDALLERQHEMNQRFAGSGRFAFRHKDSD 209

  Fly   151 ---------------------EYTMRISYLELYNEELCDLL---STDDTTKIRIFDDSTKKGSVI 191
                                 .|::.::|:|:||..:.|||   ....|.:.:|..:...: .:.
  Fly   210 PEIASQASVEPIPLLGLDEDNMYSVFVTYIEIYNNSVYDLLEDSGIQKTLQSKIIREDANR-HMF 273

  Fly   192 IQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLK--- 253
            :.|:.|:.|.:.:|..::.:.|::|::...|::||:|||||:||:|.:.......:||::::
  Fly   274 VHGVTEVEVKTVEDALEVFQMGQKRKRMGHTVLNAESSRSHSVFNIRLVQAPTDSQGENVVQDRQ 338

  Fly   254 ---IGKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVDR--------AP-HV 306
               :.:|:||||||||..|:..| .|:|:||..|||.||:||...:..|.:.        || .|
  Fly   339 NITVSQLSLVDLAGSERSSRTKN-TGVRLREAGNINNSLMTLRTCLEYLRENQLAASNGLAPKKV 402

  Fly   307 PYRESKLTRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTV 371
            |||:||:|.:.:....|..:.|:|..|:|..:|.:|.:..:::|...:.:|        :.:.|
  Fly   403 PYRDSKITHMFKNYFDGEGQVSMIVCINPRIEDYDENMQVMKFAEMTQEVQ--------IARAT- 458

  Fly   372 LKEYTEEIDKLKRDL---MAARDKNGIYLAEETYGEITLKLESQNRELNEKMLLLKALKDELQNK 433
                     .:|:||   ...|..|.::           |:...|  |||  |.:...||
  Fly   459 ---------PMKQDLGLTPGRRKANKLF-----------KIAVNN--LNE--LGIPEAKD----- 494

  Fly   434 EKIFSEVSMSLVEKTQELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEKKELVASHMKTEQVLTT 498
                .||.:.||                                 |....:..|..|.:.:. ..
  Fly   495 ----LEVDVGLV---------------------------------YSLGPDFPAYEMDSPEA-QI 521

  Fly   499 QAQEILAAADLATDDTHQLHGTIERRRELDEKIRRSCDQFKDRM----QDNLEMIGGSLNLYQDQ 559
            :.:|::          |.|...||:|::|...:...||.|:..:    :|||::        :.:
  Fly   522 KIRELM----------HYLEQRIEKRKKLRANLDIKCDSFRQMLMNLDRDNLQL--------RTE 568

  Fly   560 QAALKEQLSQEMVNSSYVSQRLALNSSKSIEMLKEMCAQSLQDQTNLHNKLIGEVMKISDQHSQA 624
            .|:||....||...|:.:.:::.::.| ||::              |:|.|..:..:|.:
  Fly   569 LASLKAVYKQERDRSAALEKKVRIHES-SIDV--------------LNNTLSKQERQIEE----- 613

  Fly   625 FVAKLMEQMQQQQLLMSKEIQTNLQVIEENNQRHKAMLDSMQEKFATIIDSSLQSVEEHAKQMHK 689
            ...||.|   ::.:|..||       .|:..|:.|     ...|.|...|.:.:..|...::...
  Fly   614 LTFKLNE---KENMLTQKE-------HEKEKQKKK-----FSSKLAVESDKNKREFELKLREQRV 663

  Fly   690 KLEQLGAMSLPDAEELQNLQEELANERALAQQEDALLESMMMQMEQIKNL-RSKNSISMSVHLNK 753
            ||:                      ||...:.|...|.|.::|.|.:.:| ||::|.::   ||:
  Fly   664 KLQ----------------------ERMRIKDEKLRLVSNILQSEDLPSLPRSQSSENI---LNE 703

  Fly   754 MEESRLTRNHRIDDIKSGIQDYQKLGIEASQSAQAELTSQMEAGMLCLDQGVAN----CSMLQVH 814
            .:....|.......:.:...|........:.:|.........||...|:...||    .:::|.:
  Fly   704 KDRGAYTARTEESSVPATRTDIYATPRHGAAAANNRHRRSRSAGDKWLEHRAANPVPLGTIMQPY 768

  Fly   815 MKNLNQ----------------KY-----EKETNENV--------------GSVRVHHNQVEIIC 844
            :||...                ||     :.:|:.:|              |..:|..|.||.:.
  Fly   769 LKNRKSVTKLTDLKELTAHGTTKYCLVSQDADTDGDVETKLYKGNVIPTCGGGAQVVFNDVECLK 833

  Fly   845 QES 847
            |:|
  Fly   834 QKS 836

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	118/440 (27%)
		Kinesin	25..356	CDD:278646	116/423 (27%)
		Microtub_bind	923..>1009	CDD:290642
pav	NP_477025.1	KISc_KIF23_like	35..450	CDD:276819	117/428 (27%)
		Kinesin	42..452	CDD:278646	116/423 (27%)
		MKLP1_Arf_bdg	735..837	CDD:293148	20/102 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437902
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840