Protein Alignment Klp61F and KIF22

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: NP_015556.1
• Gene: KIF22 / 3835
• HGNCID: 6391
• Length: 665
• Species: Homo sapiens
• Alignment Length: 722
• Identity: 204/722 - (28%)
• Similarity: 313/722 - (43%)
• Gaps: 189/722 - (26%)

  Fly     6 GNTSRQPQKKSNQNIQVYVRVRPL------NSRERCIR-----SAEVVDVVGPREVVTRHTLDSK 59
            |.|.|.|..:    ::|.||:||.      .|...|:|     |.|:.:....:|
Human    34 GATRRPPPAR----VRVAVRLRPFVDGTAGASDPPCVRGMDSCSLEIANWRNHQE---------- 84

  Fly    60 LTKKFTFDRSFGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSS 124
             |.|:.||..:|..|.|.|:|:..|.|::..:|.|.|.:|.|||.||.||||||:|:
Human    85 -TLKYQFDAFYGERSTQQDIYAGSVQPILRHLLEGQNASVLAYGPTGAGKTHTMLGS-------- 140

  Fly   125 WEDDSDIGIIPRALSHLFDELRMMEVE-----YTMRISYLELYNEELCDLLSTDDTTKIRIFDDS 184
               ....|:|||||..|....|....|     .::.:||||:|.|::.|||.......: |.:|.
Human   141 ---PEQPGVIPRALMDLLQLTREEGAEGRPWALSVTMSYLEIYQEKVLDLLDPASGDLV-IREDC 201

  Fly   185 TKKGSVIIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGE 249
              :|:::|.||.:.|:.|..|..:........|....|.:|.:|||||.|..:.|..||......
Human   202 --RGNILIPGLSQKPISSFADFERHFLPASRNRTVGATRLNQRSSRSHAVLLVKVDQRERLAPFR 264

  Fly   250 DMLKIGKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVDRAPHVPYRESKLT 314
            .  :.|||.|:||||||:..:.|| ||:|::|:..||.||..||:|:.||....|.||||:||||
Human   265 Q--REGKLYLIDLAGSEDNRRTGN-KGLRLKESGAINTSLFVLGKVVDALNQGLPRVPYRDSKLT 326

  Fly   315 RLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQ----------KLTKK 369
            ||||:||||...:.:||.|:|..:...:|:|.|.:|.|:|.:.|:|..|:          ||::|
Human   327 RLLQDSLGGSAHSILIANIAPERRFYLDTVSALNFAARSKEVINRPFTNESLQPHALGPVKLSQK 391

  Fly   370 TVLKEYTEEIDKLKRDLMAARDKNGIYLAEETYGEITLKLESQNRELNEKMLLLKALKDELQNKE 434
            .:|..     .:.||    ||...     ||..|.            .|.|....:...:|...:
Human   392 ELLGP-----PEAKR----ARGPE-----EEEIGS------------PEPMAAPASASQKLSPLQ 430

  Fly   435 KIFSEVSMSLVEKTQELKKTEENLLNTKGT----LLLTKK----VLTKTKRRYKEKKELVASHMK 491
            |: |.:..:::|:...|    :.||.::|:    ||.|.|    ||.||    .|:|:|....:|
Human   431 KL-SSMDPAMLERLLSL----DRLLASQGSQGAPLLSTPKRERMVLMKT----VEEKDLEIERLK 486

  Fly   492 TEQ------VLTTQAQE----------------ILAAADL--------------ATDDTHQLH-- 518
            |:|      :|..:|:|                :..|..|              |.....::|
Human   487 TKQKELEAKMLAQKAEEKENHCPTMLRPLSHRTVTGAKPLKKAVVMPLQLIQEQAASPNAEIHIL 551

  Fly   519 ---GTIERRRELDEKIRRSCDQF--KDRMQDNLEMIGGSLNLYQDQQAALKEQLSQEMVNSSYVS 578
               |   |:|:|:     |.|..  :::.:|..|:                 |:|.|:
Human   552 KNKG---RKRKLE-----SLDALEPEEKAEDCWEL-----------------QISPEL------- 584

  Fly   579 QRLALNSSKSIEMLKEMCAQSLQDQTNLHNK----------LIGEVMKISD-QHSQAFVAKLMEQ 632
              ||....|.:::|.|..|:.|:....:..|          |.|...::.| :..:....|.||.
Human   585 --LAHGRQKILDLLNEGSARDLRSLQRIGPKKAQLIVGWRELHGPFSQVEDLERVEGITGKQMES 647

  Fly   633 MQQQQLL 639
            ..:..:|
Human   648 FLKANIL 654

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	132/373 (35%)
		SMC_prok_B	<408..728	CDD:274008	57/294 (19%)
		SMC_prok_B	<651..>921	CDD:274008
		Microtub_bind	923..>1004	CDD:464048
KIF22	NP_015556.1	KISc_KID_like	43..366	CDD:276827	128/354 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	379..428		14/74 (19%)
		ComEA	596..646	CDD:441164	9/49 (18%)