DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp61F and KIF11

DIOPT Version :9

Sequence 1:	NP_476818.1	Gene:	Klp61F / 38135	FlyBaseID:	FBgn0004378	Length:	1066	Species:	Drosophila melanogaster
Sequence 2:	NP_004514.2	Gene:	KIF11 / 3832	HGNCID:	6388	Length:	1056	Species:	Homo sapiens

Alignment Length:	1095	Identity:	384/1095 - (35%)
Similarity:	595/1095 - (54%)	Gaps:	143/1095 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NTSRQPQKKSNQNIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHT---LDSKLTKKFTFDR 68
            |:|.:.:::..:||||.||.||.|..||...:..:|:....|:.|:..|   .|....|.:|||.
Human     6 NSSAKKKEEKGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDM 70

  Fly    69 SFGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGI 133
            .||..:||.|||..||.|:::||:.|||||:|||||||||||.||.|..:...:.:||:|...||
Human    71 VFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAGI 135

  Fly   134 IPRALSHLFDELRMMEVEYTMRISYLELYNEELCDLL--STDDTTKIRIFDDSTKKGSVIIQGLE 196
            |||.|..:|::|.....|:::::|.||:|||||.|||  |:|.:.::::|||...|..|||:|||
Human   136 IPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGVIIKGLE 200

  Fly   197 EIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIGKLNLVD 261
            ||.||:||:||::||||..:|.||.|||||.|||||:|||:.:|::|..|:||:::|||||||||
Human   201 EITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEELVKIGKLNLVD 265

  Fly   262 LAGSENVSKAGN-EKGIRVRETVNINQSLLTLGRVITALVDRAPHVPYRESKLTRLLQESLGGRT 325
            ||||||:.::|. :|  |.||..|||||||||||||||||:|.||||||||||||:||:||||||
Human   266 LAGSENIGRSGAVDK--RAREAGNINQSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRT 328

  Fly   326 KTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLKRDLMAAR 390
            :|||||||||...::||||||||||||||||.||||||||||||.::|||||||::|||||.|||
Human   329 RTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVNQKLTKKALIKEYTEEIERLKRDLAAAR 393

  Fly   391 DKNGIYLAEETYGEITLKLESQNRELNEKMLLLKALKDELQNKEKIF-------SEVSMSLVEKT 448
            :|||:|::||.:..::.||..|..::.|.:..:.|:::||....::|       .:....|..||
Human   394 EKNGVYISEENFRVMSGKLTVQEEQIVELIEKIGAVEEELNRVTELFMDNKNELDQCKSDLQNKT 458

  Fly   449 QELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEKKELVASHMK-TEQVLTTQAQEILAAADLATD 512
            |||:.|:::|..||..|:               |:|.:.|.:: ||:.|...|.::|...:..|.
Human   459 QELETTQKHLQETKLQLV---------------KEEYITSALESTEEKLHDAASKLLNTVEETTK 508

  Fly   513 DTHQLHGTIERRRELDEKIRRSCDQFKDRMQDNLEMIGGSLN-LYQDQQAALKEQLSQEM----V 572
            |...||..::|::.:|:....:.|.|           |.:|| |:.:.:..:|:..|::.    |
Human   509 DVSGLHSKLDRKKAVDQHNAEAQDIF-----------GKNLNSLFNNMEELIKDGSSKQKAMLEV 562

  Fly   573 NSSYVSQRLALNSSKSIEMLKEMCAQSLQDQTNLHNKLIGEVMKISDQHSQAFVAKLMEQMQQQQ 637
            :.:.....|    |.|:..|..:...:|...|::..       .:|...||.|...|.||.
Human   563 HKTLFGNLL----SSSVSALDTITTVALGSLTSIPE-------NVSTHVSQIFNMILKEQS---- 612

  Fly   638 LLMSKEIQTNLQVIEENNQRHKAMLDSMQEKFATIIDSSLQSVEEHAKQMHKKLEQLGAMSLPDA 702
              ::.|.:|.||  |..|.....:|.|::...:..:.|.|        :::.:|:.:...||..|
Human   613 --LAAESKTVLQ--ELINVLKTDLLSSLEMILSPTVVSIL--------KINSQLKHIFKTSLTVA 665

  Fly   703 EELQNLQEE-------LANERALAQQED--ALLESMMM---QMEQIKNLRSKNSISMSVHLNKME 755
            :::::.::|       |.|.....|:..  :|:||...   ..|.:|.::..:|..:...:|...
Human   666 DKIEDQKKELDGFLSILCNNLHELQENTICSLVESQKQCGNLTEDLKTIKQTHSQELCKLMNLWT 730

  Fly   756 ESRLTRNHRIDDIKSGIQDYQKLGIEASQSAQAELTSQM--EAGMLCLD-QGVANCSMLQVHMKN 817
            |.......:.::|:..:...|    |..|....::.::|  .:...|.| .|.:.      .::|
Human   731 ERFCALEEKCENIQKPLSSVQ----ENIQQKSKDIVNKMTFHSQKFCADSDGFSQ------ELRN 785

  Fly   818 LNQKYEKETNENVGSVRVHHNQVEIICQESKQQLEAVQEKTEVNLEQMVDARQQLITEDRQRFIG 882
            .||:..|...|:|......:..:|.|.||::|:.|::..:|....||.|.:    :.|..|....
Human   786 FNQEGTKLVEESVKHSDKLNGNLEKISQETEQRCESLNTRTVYFSEQWVSS----LNEREQELHN 846

  Fly   883 HATVATDLVQESNRQFSE-----HAEHQRQ------QLQICEQELVR------------------ 918
            ...|.:...:.|:...:|     .|.|::|      |:.|.|.:|:.
Human   847 LLEVVSQCCEASSSDITEKSDGRKAAHEKQHNIFLDQMTIDEDKLIAQNLELNETIKIGLTKLNC 911

  Fly   919 FQQSELKTYAPTGTTPSKRDFVYPRTLVATSPHQEIVRRYRQE-------LDWSDLDTTATIDEC 976
            |.:.:||...||||||.::.::||.|||.|.|.:.::.:.:::       |:.|:.:...||.:.
Human   912 FLEQDLKLDIPTGTTPQRKSYLYPSTLVRTEPREHLLDQLKRKQPELLMMLNCSENNKEETIPDV 976

  Fly   977 SEGEHDVSMHSVQELSETETIMNSTPIEPVDGVTV---KRGCGTTR-NSNSNALK 1027
            ...|..:..::.:.||:..::........:.||..   |:..|..: |...|.|:
Human   977 DVEEAVLGQYTEEPLSQEPSVDAGVDCSSIGGVPFFQHKKSHGKDKENRGINTLE 1031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	208/353 (59%)
		Kinesin	25..356	CDD:278646	195/336 (58%)
		Microtub_bind	923..>1009	CDD:290642	22/92 (24%)
KIF11	NP_004514.2	KISc_BimC_Eg5	16..368	CDD:276815	208/353 (59%)
		KISc	18..366	CDD:214526	206/349 (59%)
		Microtub_bind	916..1053	CDD:290642	29/116 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158392
Domainoid	1	1.000	376	1.000	Domainoid score	I871
eggNOG	1	0.900	-	-		E2759_KOG0243
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3322
Inparanoid	1	1.050	553	1.000	Inparanoid score	I1124
Isobase	1	0.950	-	0	Normalized mean entropy	S2292
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111985at33208
OrthoFinder	1	1.000	-	-		FOG0002556
OrthoInspector	1	1.000	-	-		oto91443
orthoMCL	1	0.900	-	-		OOG6_102884
Panther	1	1.100	-	-	LDO	PTHR47970
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4221
SonicParanoid	1	1.000	-	-		X1681
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.740