Protein Alignment Klp61F and KIF5C

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: NP_004513.1
• Gene: KIF5C / 3800
• HGNCID: 6325
• Length: 957
• Species: Homo sapiens
• Alignment Length: 1076
• Identity: 280/1076 - (26%)
• Similarity: 475/1076 - (44%)
• Gaps: 204/1076 - (18%)

  Fly    19 NIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHTLDSKLTKKFTFDRSFGPESKQCDVYSVV 83
            :|:|..|.||||..|.......:....|...||...      .|.:.|||...|.:.|..||:..
Human     8 SIKVMCRFRPLNEAEILRGDKFIPKFKGDETVVIGQ------GKPYVFDRVLPPNTTQEQVYNAC 66

  Fly    84 VSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGIIPRALSHLFDELRMM 148
            ...::::||.|||.|:||||||.:||||||.|        ...|...:|||||....:||.:..|
Human    67 AKQIVKDVLEGYNGTIFAYGQTSSGKTHTMEG--------KLHDPQLMGIIPRIAHDIFDHIYSM 123

  Fly   149 E--VEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSVIIQGLEEIPVHSKDDVYKLLE 211
            :  :|:.:::||.|:|.:::.|||   |.:|..:.....|.....::|..|..|.|.::|..:::
Human   124 DENLEFHIKVSYFEIYLDKIRDLL---DVSKTNLAVHEDKNRVPYVKGCTERFVSSPEEVMDVID 185

  Fly   212 KGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIGKLNLVDLAGSENVSKAGNEKG 276
            :||..|..|.|.||..|||||::|  :::|::..:|.|..|. |||.||||||||.|||.|.| |
Human   186 EGKANRHVAVTNMNEHSSRSHSIF--LINIKQENVETEKKLS-GKLYLVDLAGSEKVSKTGAE-G 246

  Fly   277 IRVRETVNINQSLLTLGRVITALVD-RAPHVPYRESKLTRLLQESLGGRTKTSIIATISPGHKDI 340
            ..:.|..|||:||..||.||:||.: ...|||||:||:||:||:||||..:|:|:...||...:.
Human   247 AVLDEAKNINKSLSALGNVISALAEGTKTHVPYRDSKMTRILQDSLGGNCRTTIVICCSPSVFNE 311

  Fly   341 EETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLKR--------DLMAARDKNGIYL 397
            .||.|||.:..|||.|:|...||.:||.:...|:|.:|.:|.|.        ::...|.:||..:
Human   312 AETKSTLMFGQRAKTIKNTVSVNLELTAEEWKKKYEKEKEKNKTLKNVIQHLEMELNRWRNGEAV 376

  Fly   398 AEETYGEITLKLESQNRELNEKMLLLKALKD-----ELQNKEKIFSEVS---MSLVEKTQELKKT 454
            .|:.  :|:.| :.:|.|..:...::..:..     ..:.|||...|:|   ..|.:|..|:.:.
Human   377 PEDE--QISAK-DQKNLEPCDNTPIIDNIAPVVAGISTEEKEKYDEEISSLYRQLDDKDDEINQQ 438

  Fly   455 EENLLNTKGTLLLTKKVLTKTKRRY-KEKKELVASHMKTEQVLTTQAQEILAAADLATDDTHQLH 518
            .:.....|..:|...::|..|:|.| |.::||....::.|.......:.:.|..:||.:..
Human   439 SQLAEKLKQQMLDQDELLASTRRDYEKIQEELTRLQIENEAAKDEVKEVLQALEELAVNYD---- 499

  Fly   519 GTIERRRELDEKIRRSCDQFKDRMQDNLEMIGGSLNLYQDQQAALKEQLSQEMVNSSYVSQRLAL 583
               ::.:|:::|.|.:                              |||:.|:...:    ....
Human   500 ---QKSQEVEDKTRAN------------------------------EQLTDELAQKT----TTLT 527

  Fly   584 NSSKSIEMLKEMCAQSLQDQTNLHNKL------IGEVMKISDQHSQAFV-AKLMEQMQQQQLLMS 641
            .:.:.:..|:|:.....:..|.:.|.|      ||.::..:|..:.|.| ..:.|:....:|.:|
Human   528 TTQRELSQLQELSNHQKKRATEILNLLLKDLGEIGGIIGTNDVKTLADVNGVIEEEFTMARLYIS 592

  Fly   642 KEIQTNLQVIEENNQRHKAMLDSMQEKFATIIDSSLQSVEEHAKQMHKKLEQLGAMSLPDAEELQ 706
            |.......::..:.|...|.:||.::..|:  :..|.:.:....|...|::.|       .:.:|
Human   593 KMKSEVKSLVNRSKQLESAQMDSNRKMNAS--ERELAACQLLISQHEAKIKSL-------TDYMQ 648

  Fly   707 NLQEELANERALAQQEDALLESMMMQMEQIKNLRSKNSISMSVHLNKMEESRLTRNHRIDDIKSG 771
            |::::   .|.|.:.:|:|       .|::..||::..:. .|.....|:..|||....:::|..
Human   649 NMEQK---RRQLEESQDSL-------SEELAKLRAQEKMH-EVSFQDKEKEHLTRLQDAEEMKKA 702

  Fly   772 IQDYQKLGIEASQSAQAELTSQMEAGMLCLDQGVANCSMLQVHMKNLNQKYEKETNENVGSVRVH 836
            ::...:...||.|...:.|..::|.....:|:           :::||||.:.| .|.:.|   .
Human   703 LEQQMESHREAHQKQLSRLRDEIEEKQKIIDE-----------IRDLNQKLQLE-QEKLSS---D 752

  Fly   837 HNQVEIICQESKQQLE---AVQEKTE------VNLEQMVDARQQLITEDRQRFIGHATVATDLVQ 892
            :|:::|..||.:.:||   .:.:|.|      ..||:.|....|.:...|:.|:...|.......
Human   753 YNKLKIEDQEREMKLEKLLLLNDKREQAREDLKGLEETVSRELQTLHNLRKLFVQDLTTRVKKSV 817

  Fly   893 E----------SNRQFSEHAEHQRQQLQICEQELVRFQQSELKTYAPTGTTPSKRDFVYPRTLVA 947
            |          :.:|.....|:..:||....::||| ..::|:...|.          ..:.|.|
Human   818 ELDNDDGGGSAAQKQKISFLENNLEQLTKVHKQLVR-DNADLRCELPK----------LEKRLRA 871

  Fly   948 TSPHQEIV---------------RRYRQELDWSDLDTTATIDECSEGEHDVSM----HSVQELSE 993
            |:...:.:               :||:||           :|...|.....:|    ||.|
Human   872 TAERVKALESALKEAKENAMRDRKRYQQE-----------VDRIKEAVRAKNMARRAHSAQ---- 921

  Fly   994 TETIMNSTPIE----PVDGVT----VKRGCGTTRNS 1021
                 .:.||.    |....|    ::.|.|::.||
Human   922 -----IAKPIRPGHYPASSPTAVHAIRGGGGSSSNS 952

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	140/348 (40%)
		SMC_prok_B	<408..728	CDD:274008	60/335 (18%)
		SMC_prok_B	<651..>921	CDD:274008	60/288 (21%)
		Microtub_bind	923..>1004	CDD:464048	16/99 (16%)
KIF5C	NP_004513.1	KISc_KHC_KIF5	6..327	CDD:276820	136/339 (40%)
		Microtubule-binding	174..315		69/144 (48%)
		PRK03918	<412..907	CDD:235175	112/592 (19%)
		Khc_CBD_cc	836..905	CDD:467880	16/90 (18%)
		Globular	859..956		22/124 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	911..957		12/51 (24%)