Protein Alignment Klp61F and KIF5B

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: NP_004512.1
• Gene: KIF5B / 3799
• HGNCID: 6324
• Length: 963
• Species: Homo sapiens
• Alignment Length: 1135
• Identity: 276/1135 - (24%)
• Similarity: 473/1135 - (41%)
• Gaps: 275/1135 - (24%)

  Fly    19 NIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHTLDSKLTKKFTFDRSFGPESKQCDVYSVV 83
            ||:|..|.||||..|.......:....|...||.       .:|.:.|||.|...:.|..||:..
Human     8 NIKVMCRFRPLNESEVNRGDKYIAKFQGEDTVVI-------ASKPYAFDRVFQSSTSQEQVYNDC 65

  Fly    84 VSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGIIPRALSHLFDELRMM 148
            ...::::||.|||.|:||||||.:||||||.|        ...|...:|||||.:..:|:.:..|
Human    66 AKKIVKDVLEGYNGTIFAYGQTSSGKTHTMEG--------KLHDPEGMGIIPRIVQDIFNYIYSM 122

  Fly   149 E--VEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSVIIQGLEEIPVHSKDDVYKLLE 211
            :  :|:.:::||.|:|.:::.|||   |.:|..:.....|.....::|..|..|.|.|:|...::
Human   123 DENLEFHIKVSYFEIYLDKIRDLL---DVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTID 184

  Fly   212 KGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIGKLNLVDLAGSENVSKAGNEKG 276
            :||..|..|.|.||..|||||::|  ::::::...:.|..|. |||.||||||||.|||.|.| |
Human   185 EGKSNRHVAVTNMNEHSSRSHSIF--LINVKQENTQTEQKLS-GKLYLVDLAGSEKVSKTGAE-G 245

  Fly   277 IRVRETVNINQSLLTLGRVITALVDRAPHVPYRESKLTRLLQESLGGRTKTSIIATISPGHKDIE 341
            ..:.|..|||:||..||.||:||.:.:.:||||:||:||:||:||||..:|:|:...||...:..
Human   246 AVLDEAKNINKSLSALGNVISALAEGSTYVPYRDSKMTRILQDSLGGNCRTTIVICCSPSSYNES 310

  Fly   342 ETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLK----------------------- 383
            ||.|||.:..|||.|:|...||.:||.:...|:|.:|.:|.|
Human   311 ETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKILRNTIQWLENELNRWRNGETVP 375

  Fly   384 ------------------RDLMAARDKNGIYL-------------AEETYGEITLKLESQNRELN 417
                              :|:....||....:             .||...::..:|:.::.|:|
Human   376 IDEQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAERRKCEEEIAKLYKQLDDKDEEIN 440

  Fly   418 EKMLLLKALKDELQNKEKIFSEVSMSLVEKTQELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEK 482
            ::..|::.||.::.::|::.:...........||.:.:.....:|..:....:.|.:....|.:|
Human   441 QQSQLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAVNYDQK 505

  Fly   483 KELVASHMKTEQVLTTQAQEILAAADLATDDTHQLHGTIERRREL-DEKIRRSCDQFKDRMQDNL 546
            .:.|....|..::|:.:..:  .:|.||:.|..     :::.:|: :.:.:|:.:.....::|..
Human   506 SQEVEDKTKEYELLSDELNQ--KSATLASIDAE-----LQKLKEMTNHQKKRAAEMMASLLKDLA 563

  Fly   547 EM---IGGSLNLYQDQQAALKEQLSQEMVNSSYVSQRLALNSSKS-IEMLKEMCAQSLQDQTNLH 607
            |:   :|.:         .:|:.....|::..:...||.::..|| ::.:.:.|.|....||..:
Human   564 EIGIAVGNN---------DVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESN 619

  Fly   608 NKLIGEVMKISDQHSQAFVAKLMEQMQQQQLLMSKEIQTNLQVIEENNQRHKAMLDSMQEKFATI 672
            .|:                               :|.:..|...:....:|:|.:.|:.|
Human   620 KKM-------------------------------EENEKELAACQLRISQHEAKIKSLTE----- 648

  Fly   673 IDSSLQSVEEHAKQMHKKLEQLGAMSLPDAEELQNLQEELANERALAQQEDALLESMMMQMEQIK 737
               .||:||:..:|:.              |.:..|.|||...||..:..:       |:.|.:.
Human   649 ---YLQNVEQKKRQLE--------------ESVDALSEELVQLRAQEKVHE-------MEKEHLN 689

  Fly   738 NLRSKNSISMSVHLNKMEESRLTRNHRIDDIKSGIQDYQKLGIEASQSAQAELTSQMEAGMLCLD 802
            .:::.|.:..:|. .:::..|.|...:|..::..::            |:|:|.:.::      |
Human   690 KVQTANEVKQAVE-QQIQSHRETHQKQISSLRDEVE------------AKAKLITDLQ------D 735

  Fly   803 QGVANCSMLQVHMKNLNQKYEKETNENVGSVRVHHNQVEIICQESKQQLEAVQEKTEVNLEQMVD 867
            |               |||...|...    :||.|.:::...||..::|.        .|..|.|
Human   736 Q---------------NQKMMLEQER----LRVEHEKLKATDQEKSRKLH--------ELTVMQD 773

  Fly   868 ARQQLITEDRQRFIG-HATVATDL----------VQESNRQFSEHAE----------HQRQQLQI 911
            .|:|.    ||...| ..|||.:|          ||:...:..:.||          .|:|::..
Human   774 RREQA----RQDLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSAEIDSDDTGGSAAQKQKISF 834

  Fly   912 CEQELVRFQQSELKTYAPTGTTPSKRDFVYPRTLVATSPHQEIVR---RYRQELDWSDLDTTATI 973
            .|..|.:.                            |..|:::||   ..|.||...:....||.
Human   835 LENNLEQL----------------------------TKVHKQLVRDNADLRCELPKLEKRLRATA 871

  Fly   974 DECSEGEHDVSMHSVQELSETETIMNSTPIEPVDGV-TVKRGCGTTRNSNSNALKPPVATGGKRS 1037
            :.....|     .:::|..|..:.......:.||.: ...|.....|..:|..:..|:..|...:
Human   872 ERVKALE-----SALKEAKENASRDRKRYQQEVDRIKEAVRSKNMARRGHSAQIAKPIRPGQHPA 931

  Fly  1038 SSLSRSLTPSKTSP-RGSPAFVRHNKENVA 1066
            :|      |:..|. ||..|||: |.:.||
Human   932 AS------PTHPSAIRGGGAFVQ-NSQPVA 954

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	138/347 (40%)
		SMC_prok_B	<408..728	CDD:274008	54/324 (17%)
		SMC_prok_B	<651..>921	CDD:274008	58/290 (20%)
		Microtub_bind	923..>1004	CDD:464048	12/83 (14%)
KIF5B	NP_004512.1	KISc_KHC_KIF5	6..325	CDD:276820	134/338 (40%)
		SMC_prok_B	<414..803	CDD:274008	90/514 (18%)
		Khc_CBD_cc	834..903	CDD:467880	16/101 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	908..963		15/54 (28%)
		Globular	915..963		14/47 (30%)