DRSC/TRiP Functional Genomics Resources

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Protein Alignment Klp61F and KIF3C

DIOPT Version :10

Sequence 1:NP_476818.1 Gene:Klp61F / 38135 FlyBaseID:FBgn0004378 Length:1066 Species:Drosophila melanogaster
Sequence 2:NP_002245.4 Gene:KIF3C / 3797 HGNCID:6321 Length:793 Species:Homo sapiens


Alignment Length:838 Identity:240/838 - (28%)
Similarity:390/838 - (46%) Gaps:190/838 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 KSNQNIQVYVRVRPLNSRERCIRSAEV--VDV-VGPREVVTRHTLDSKLTKKFTFDRSFGPESKQ 76
            |:::.::|..|.|||:.:|......::  :|| :|...:........:|.|.||||..:...|||
Human     6 KASEALKVVARCRPLSRKEEAAGHEQILTMDVKLGQVTLRNPRAAPGELPKTFTFDAVYDASSKQ 70

  Fly    77 CDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGIIPRALSHL 141
            .|:|...|.|||:.||.|:|.|||||||||||||:||.|        :|.:....|:||.|..|:
Human    71 ADLYDETVRPLIDSVLQGFNGTVFAYGQTGTGKTYTMQG--------TWVEPELRGVIPNAFEHI 127

  Fly   142 FDEL-RMMEVEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSVIIQGLEEIPVHSKDD 205
            |..: |....:|.:|.||||:|.||:.||||.:...::.:.::  .:..|.|:.|......:..:
Human   128 FTHISRSQNQQYLVRASYLEIYQEEIRDLLSKEPGKRLELKEN--PETGVYIKDLSSFVTKNVKE 190

  Fly   206 VYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIGKLNLVDLAGSENVSK 270
            :..::..|.:.|...:|.||..|||||.:|.|.|...|.|.:|:|.:::||||||||||||..:|
Human   191 IEHVMNLGNQTRAVGSTHMNEVSSRSHAIFIITVECSERGSDGQDHIRVGKLNLVDLAGSERQNK 255

  Fly   271 A-----------------------GNEKGIRVRETVNINQSLLTLGRVITALV-DRAPHVPYRES 311
            |                       |...|.|.:|...||.||..||.||.||. :|:.|:|||:|
Human   256 AGPNTAGGAATPSSGGGGGGGGSGGGAGGERPKEASKINLSLSALGNVIAALAGNRSTHIPYRDS 320

  Fly   312 KLTRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYT 376
            |||||||:||||..||.::||:.|.....:|:||||.:|:|||||:|||.||:. .|.|:|:|:.
Human   321 KLTRLLQDSLGGNAKTIMVATLGPASHSYDESLSTLRFANRAKNIKNKPRVNED-PKDTLLREFQ 384

  Fly   377 EEIDKLKRDL------------MAARDKNGI--------------YLAEETYGEITLKLESQNRE 415
            |||.:||..|            .::|.|..:              ::|||               
Human   385 EEIARLKAQLEKRGMLGKRPRRKSSRRKKAVSAPPGYPEGPVIEAWVAEE--------------- 434

  Fly   416 LNEKMLLLKALKDELQNKEKIFSEVSMSLVEKTQE--LKKTEENLLNTKGTLLLTKKVLTKTKRR 478
                       :|:..|..:....:..|.:||..|  |::.:|.|...|..:...:.::::.|::
Human   435 -----------EDDNNNNHRPPQPILESALEKNMENYLQEQKERLEEEKAAIQDDRSLVSEEKQK 488

  Fly   479 YKEKKELVASHMKTEQVLTTQAQEILAAADLA------------TDDTHQLHGTIE-RRRELDEK 530
            ..|:||.:...::.||    ||.|:|||...|            .|.|::....:| :|:|:.|:
Human   489 LLEEKEKMLEDLRREQ----QATELLAAKYKAMESKLLIGGRNIMDHTNEQQKMLELKRQEIAEQ 549

  Fly   531 IRRSCDQFKDRM---QDNLEMIGGSLNLYQDQQAALKEQLSQEMVNSSYVSQRLALNSSKSIEML 592
            .||..:..::.|   ::.:|:.|...:|.|:.:...|:                          |
Human   550 KRREREMQQEMMLRDEETMELRGTYTSLQQEVEVKTKK--------------------------L 588

  Fly   593 KEMCAQSLQDQTNLHNKLIGEVMKISDQHSQAF-VAKLMEQMQQQQLLMSKEIQTNLQVI----- 651
            |:           |:.||.....:|.|||.:.. |.:.:|:.|.:|   ::|::....:|     
Human   589 KK-----------LYAKLQAVKAEIQDQHDEYIRVRQDLEEAQNEQ---TRELKLKYLIIENFIP 639

  Fly   652 --EENNQRHKAMLDSMQE--KFATIIDSSLQS----------------VEEHAK-----QMHKKL 691
              |:|...::..||..:|  ||..::.:.:.|                :.::|:     ..|.:.
Human   640 PEEKNKIMNRLFLDCEEEQWKFQPLVPAGVSSSQMKKRPTSAVGYKRPISQYARVAMAMGSHPRY 704

  Fly   692 EQLGAMSL------PDAEELQNLQEELANERALAQQEDALLESMMMQMEQIKNLRSKN 743
            .....|.|      |...|::...::..:.|||..:....|:|.:.:....|..:|::
Human   705 RAENIMFLELDVSPPAVFEMEFSHDQEQDPRALHMERLMRLDSFLERPSTSKVRKSRS 762

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Klp61FNP_476818.1 KISc_BimC_Eg5 17..365 CDD:276815 151/375 (40%)
SMC_prok_B <408..728 CDD:274008 70/374 (19%)
SMC_prok_B <651..>921 CDD:274008 22/129 (17%)
Microtub_bind 923..>1004 CDD:464048
KIF3CNP_002245.4 KISc_KIF3 9..365 CDD:276822 144/365 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 251..288 6/36 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 394..424 3/29 (10%)
Smc <452..>635 CDD:440809 48/226 (21%)
Globular. /evidence=ECO:0000255 630..793 22/133 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 750..793 2/13 (15%)
Blue background indicates that the domain is not in the aligned region.

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