DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp61F and kif1b

DIOPT Version :9

Sequence 1:	NP_476818.1	Gene:	Klp61F / 38135	FlyBaseID:	FBgn0004378	Length:	1066	Species:	Drosophila melanogaster
Sequence 2:	XP_009295087.1	Gene:	kif1b / 369190	ZFINID:	ZDB-GENE-030820-1	Length:	1924	Species:	Danio rerio

Alignment Length:	942	Identity:	232/942 - (24%)
Similarity:	400/942 - (42%)	Gaps:	239/942 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SNQNIQVYVRVRPLNSRE-----RCI-----RSAEVVDVVGPREVVTRHTLDSKLTKKFTFDRSF 70
            |..:::|.|||||.||||     :||     .|..:::...|:|           .|.|:||.|:
Zfish     2 SGASVKVAVRVRPFNSRETGKESKCIIQMQGNSTTILNPKNPKE-----------PKTFSFDYSY 55

  Fly    71 ----GPE----SKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWED 127
                .|:    :.|..||:.:...:::....|||..:|||||||.||::||:|.         ::
Zfish    56 WSHTSPDDPSFASQNQVYNDIGKEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGK---------QE 111

  Fly   128 DSDIGIIPRALSHLFDEL---RMMEVEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGS 189
            :...||||:....||:::   ...|:.|::.::|:|:|.|.:.|||:..:...:|:.:....  .
Zfish   112 EGQEGIIPQLCEELFEKINDNNNEEISYSVEVAYMEIYCERVRDLLNPKNKGNLRVREHPLL--G 174

  Fly   190 VIIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGE-DMLK 253
            ..::.|.::.|.|..|:..|::.|.:.|..|.|.||..|||||.||:||...|:...|.: ...|
Zfish   175 PYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQRKYDSETDLSTEK 239

  Fly   254 IGKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVD------------RAPHV 306
            :.|::||||||||.....| .||.|::|..|||:||.|||:||:||.:            :...:
Zfish   240 VSKISLVDLAGSERADSTG-AKGTRLKEGANINKSLTTLGKVISALAEVDNCTSKSKKKKKTDFI 303

  Fly   307 PYRESKLTRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTV 371
            |||:|.||.||:|:|||.::|:::|.:||...:.:||||||.||.|||.|:....:|:....|.|
Zfish   304 PYRDSVLTWLLRENLGGNSRTAMVAALSPADINFDETLSTLRYADRAKQIKCNAVINEDPNAKLV 368

  Fly   372 LKEYTEEIDKLKRDLMAARDKNGIYLAEETYGEITLKLESQNRELNEKMLLLKALKDELQNKEK- 435
             :|..:|:.:|| :|:.|:....| |..|..|:..|...|:..::|:...||.:..:.:..:.|
Zfish   369 -RELKDEVSRLK-ELLRAQGLGDI-LDIEPMGDDCLGSGSKCDDINDVKTLLSSQTEAMLYRRKA 430

  Fly   436 -----IFSEVSMSLVEKT--QELKKTEENLLNTKG------TLLLTKKVLTKTKRRYKEK-KELV 486
                 ..|..|.||..:.  |.:...:|.:::|.|      .|..::|::.:....::|| ::..
Zfish   431 PMGCLTASPSSGSLCSQAGLQSVSSIQERIMSTPGGEEAIERLKESEKIIAELNETWEEKLRKTE 495

  Fly   487 ASHMKTEQVLTTQAQEI----------------------LAAADLATDDTHQLHGTIERRRELDE 529
            |..|:.|.:|......|                      |:..|.:...::||.
Zfish   496 AIRMEREALLAEMGVAIREDGGTLGVFSPKKFGPDRPTSLSIEDFSVYSSNQLF----------- 549

  Fly   530 KIRRSCDQFKD----------------------------RMQDNLEMIGGSLNLYQDQQAALKEQ 566
             :.|.|:.:.|                            .::|.:..:|        |..|.:.|
Zfish   550 -VERPCEVYTDFNGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGITRVG--------QADAERRQ 605

  Fly   567 ---LSQEMVNSSYVSQRLALNSSKSIEMLKEMCAQSLQDQTNLHNKLIGEVMKISD--------- 619
               ||...:...:...|...|::..:.:..|.|..|   :|.::.|.:...:::..
Zfish   606 DIVLSGAHIKEEHCIFRSERNANGHVIVTLEPCEGS---ETYVNGKRVNSAVQLRSGNRIIMGKN 667

  Fly   620 -----QHSQAFVAK-------------------LMEQMQQQQLLMSKEIQTNLQVIEENNQRHKA 660
                 .|.:...|:                   ..|.:::|.:.|.:|::..|..:|...::.|.
Zfish   668 HVFRFNHPEQARAEREKTPSAETPVEPVDWTFAQRELLEKQGIDMKQEMEKRLTEMEILYKKEKE 732

  Fly   661 MLDSMQEKFATIIDSSLQSVEEHAKQMHKKLEQLG-AMSLPDAEELQNLQEELANERALAQQEDA 724
            ..|.:.|:...:.:|.||       ::.|::|... |...||.||    :||..:|....|.:..
Zfish   733 EADQLLEQQRLVYESKLQ-------ELQKQVETRSLAAETPDEEE----EEEEEDEVPWTQHKYE 786

  Fly   725 LLE--SMMMQMEQIKNLRS---------KNSISMSVHLNKM------------------------ 754
            |.:  ....:..|..:||.         |.:.::||.|.|.
Zfish   787 LAQWAFRKWRYHQFTSLRDQLWGNAVYLKEANAISVELKKKVQFQFVLLTDTLYSPLPPELLPPE 851

  Fly   755 -EESRLTRNH-------RIDDIKSGIQDYQKL 778
             |:.|..|..       .:.|:|:|...|..|
Zfish   852 PEKERDARPFPRTVVAVEVQDLKNGATHYWSL 883

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	133/381 (35%)
		Kinesin	25..356	CDD:278646	129/364 (35%)
		Microtub_bind	923..>1009	CDD:290642
kif1b	XP_009295087.1	KISc_KIF1A_KIF1B	4..360	CDD:276816	132/378 (35%)
		KISc	5..360	CDD:214526	132/377 (35%)
		Kinesin_assoc	357..593	CDD:292801	44/250 (18%)
		FHA	570..674	CDD:238017	14/114 (12%)
		FHA	<580..672	CDD:224630	14/102 (14%)
		GBP_C	<677..751	CDD:303769	13/80 (16%)
		KIF1B	886..934	CDD:289208
		DUF3694	1417..1526	CDD:289256
		PH_KIFIA_KIFIB	1805..1907	CDD:269939
		PH	1810..1903	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910