Protein Alignment Klp61F and unc-104

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: NP_611155.3
• Gene: unc-104 / 36876
• FlyBaseID: FBgn0267002
• Length: 1739
• Species: Drosophila melanogaster
• Alignment Length: 1197
• Identity: 292/1197 - (24%)
• Similarity: 481/1197 - (40%)
• Gaps: 296/1197 - (24%)

  Fly    19 NIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTR-----HTLDSKLTKKFTFDRSFGPE----- 73
            :::|.|||||.||||....|..::::.|....:|.     :|.||  .|:|.||.|:...
  Fly     3 SVKVAVRVRPFNSREIARESKCIIEMAGATTAITNPKVPPNTSDS--VKRFNFDYSYWSHDHHDA 65

  Fly    74 --SKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGIIPR 136
              |.|..||..:...:::...:|||..:|||||||.||::||:|.         :::...||||.
  Fly    66 DFSTQSMVYKDIGEEMLQHSFDGYNVCIFAYGQTGAGKSYTMMGR---------QEEQQEGIIPM 121

  Fly   137 ALSHLFDELRMME---VEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSVIIQGLEEI 198
            ....||..::..|   ::|::.:||:|:|.|.:.|||:..:...:|:.:....  ...::.|.::
  Fly   122 ICKDLFTRIQDTETDDLKYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLL--GPYVEDLSKL 184

  Fly   199 PVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDML------KIGKL 257
            .|....|::.|:::|.:.|..|.|.||..|||||.||:|....|.:     |::      |:.|:
  Fly   185 AVTDYQDIHDLIDEGNKARTVAATNMNETSSRSHAVFTIFFTQRRH-----DLMTNLTTEKVSKI 244

  Fly   258 NLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVD---------RAPHVPYRESKL 313
            :||||||||.....| .||.|::|..|||:||.|||:||:||.:         :|..:|||:|.|
  Fly   245 SLVDLAGSERADSTG-AKGTRLKEGANINKSLTTLGKVISALAEVASKKKNTKKADFIPYRDSAL 308

  Fly   314 TRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEE 378
            |.||:|:|||.:||::||.|||...:.:||||||.||.|||.|..|..||:....| :::|..||
  Fly   309 TWLLRENLGGNSKTAMIAAISPADINYDETLSTLRYADRAKQIVCKAVVNEDANAK-LIRELKEE 372

  Fly   379 IDKLKRDLMAARDKNGIYLAEETYGEITLK--LESQNRELNEKMLLLKALKDELQNKEKIFSEVS 441
            |.|| |||:.|   .||.:.||  .|:|..  ::|..:..|......:...|:||..||:.:|::
  Fly   373 IQKL-RDLLKA---EGIEVQEE--DELTKSTVIKSPTKSRNRNGSTTEMAVDQLQASEKLIAELN 431

  Fly   442 MSLVEKTQELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEKKELVASHMKTEQVLTTQAQEILAA 506
            .:..||   ||:|||                                       :..|.:.:.|.
  Fly   432 ETWEEK---LKRTEE---------------------------------------IRVQREAVFAE 454

  Fly   507 ADLATDDTHQLHGTIERRR-----ELDEKIRRS-CDQFKDRMQDNLEMIG-GSLNLYQDQQAA-- 562
            ..:|..:.....|....::     .|:|....| |..:  .:::.|..:| ...|:.||.|.:
  Fly   455 MGVAVKEDGITVGVFSPKKTPHLVNLNEDPNLSECLLY--YIKEGLTRLGTHEANVPQDIQLSGS 517

  Fly   563 --LKEQLSQEMVNSS-----------YVS-------------QRLALNSSKSIEMLKEMCAQSLQ 601
              |||..:.|..||:           ||:             .|:.|..:..........|:.|:
  Fly   518 HILKEHCTFENKNSTVTLLPHKDAIIYVNGRKLVEPEVLKTGSRVILGKNHVFRFTNPEQARELR 582

  Fly   602 DQTNLHNKLIGEVMKISDQHSQAFVAKLMEQMQQQQLLMSKEIQTNLQVIEENNQRHKAMLDSMQ 666
            |:....|:...||.|...|......|: .|.:::|.:.:..|::..|..:||..:|.|...|...
  Fly   583 DKIETENEAENEVEKTDTQQVDWNFAQ-CELLEKQGIDLKAEMKKRLDNLEEQYKREKLQADQQF 646

  Fly   667 EKFATIIDSSLQSVEEHAKQMHKKLEQLGAMSLPDAEELQNLQEELANERALAQQEDALL--ESM 729
            |:.....::.:.::::..::....:....:.|..|..:.:::......|.....:|..|.  ...
  Fly   647 EEQRKTYEARIDALQKQVEEQSMTMSMYSSYSPEDFHQEEDVYTNPMYESCWTAREAGLAAWAFR 711

  Fly   730 MMQMEQIKNLRS---------KNSISMSVHLNKMEE-------------------SRLTRNHRID 766
            ..:..|..:||.         |.:.::||.|.|..:                   |.:...|:.|
  Fly   712 KWRYHQFTSLRDDLWGNAIFLKEANAISVELKKKVQFQFTLLTDTLYSPLPPELASTVAPVHQED 776

  Fly   767 -----------------DIKSGIQDYQKL--------------GIEASQSAQAELTSQMEAGMLC 800
                             |.|:|...:..|              .:|:..|:....||.|||
  Fly   777 EFGAPPVSKTLVAVEVTDTKNGATHHWSLEKLRYRLELMRQIYNVESPPSSMLFDTSGMEA---- 837

  Fly   801 LDQGVANCSM---LQVHMKNLNQKYEKETNE-NVGSVRVHHNQVEIICQESKQQLEAVQEKTEVN 861
            |...::..|.   .|..:..|....|.|... .:.::.....::|::.:....:.|......:.|
  Fly   838 LSGWISPPSQHPGQQAQLLPLEPPVESERGRLTLANLIPSRQRLELMREMYHNEAEMSPTSPDYN 902

  Fly   862 LEQMVDARQQLITEDRQRFIGHATVATDLVQESNRQFSEHAEHQ----------RQQLQIC---- 912
            :|.:...     .....||.....|....:..||..:.....|:          |..|:|.
  Fly   903 VESLTGG-----DPFYDRFPWFRMVGRSFIYLSNLLYPVPLVHKVAIVNERGDVRGYLRIAVQPV 962

  Fly   913 -EQELVRF----QQSELKTYAPTGTTPSKRDFVYPRTLVATSPHQEIVRRY---------RQELD 963
             ::|.:.|    :||....:......|..|          ....::.|:||         .:||:
  Fly   963 LDEESIDFNNGVKQSARLVFNEDDAKPKYR----------ALNEKDDVQRYIDNGGLDSKLEELE 1017

  Fly   964 WSDLDTTATID-----ECSE-----GEH------------------------DV-----SMHSVQ 989
              |:|:...||     ||.|     |||                        |:     .:|..:
  Fly  1018 --DVDSGRGIDSNSASECHENSEEPGEHLQVGKEFTFRVTVLQATGIGAEYADIFCQFNFLHRHE 1080

  Fly   990 ELSETETIMNSTPIEP-----VDGVTV 1011
            |...||.:.||....|     |..:||
  Fly  1081 EAFSTEPVKNSASGAPLGFYHVQNITV 1107

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	139/375 (37%)
		SMC_prok_B	<408..728	CDD:274008	63/358 (18%)
		SMC_prok_B	<651..>921	CDD:274008	54/353 (15%)
		Microtub_bind	923..>1004	CDD:464048	24/128 (19%)
unc-104	NP_611155.3	KISc_KIF1A_KIF1B	2..358	CDD:276816	137/373 (37%)
		Kinesin_assoc	355..498	CDD:465047	42/193 (22%)
		FHA_KIF1	474..574	CDD:438757	20/101 (20%)
		YhaN	<575..>666	CDD:443752	19/91 (21%)
		KIF1B	878..924	CDD:463574	7/50 (14%)
		DUF3694	1199..1347	CDD:463599
		PH_KIFIA_KIFIB	1602..1704	CDD:269939