Protein Alignment Klp61F and Khc-73

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: NP_001261000.1
• Gene: Khc-73 / 36718
• FlyBaseID: FBgn0019968
• Length: 1957
• Species: Drosophila melanogaster
• Alignment Length: 1116
• Identity: 273/1116 - (24%)
• Similarity: 451/1116 - (40%)
• Gaps: 303/1116 - (27%)

  Fly    16 SNQNIQVYVRVRPLNSRE-----RCIRSAE----VVDVVGPREVVTRHTLDSKLTKKFTFDRSF- 70
            ::..|:|.|||||.|.||     :||...|    ::....|.|.:.|     |..|.|.||..|
  Fly     2 ASDKIKVAVRVRPFNRREIELDTKCIVEMEKQQTILQNPPPLEKIER-----KQPKTFAFDHCFY 61

  Fly    71 --GPE----SKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDS 129
              .||    :.|..|:..|...:::....|||..:|||||||:||::||:|.:.::
  Fly    62 SLNPEDENFASQETVFDCVGRGILDNAFQGYNACIFAYGQTGSGKSYTMMGTQESK--------- 117

  Fly   130 DIGIIPRALSHLFDEL---RMMEVEYTMRISYLELYNEELCDLLS---TDDTTKIRIFDDSTKKG 188
              |||||....||..:   ...|:.|.:.:||:|:|||::.|||.   ...:.|:|   :....|
  Fly   118 --GIIPRLCDQLFSAIANKSTPELMYKVEVSYMEIYNEKVHDLLDPKPNKQSLKVR---EHNVMG 177

  Fly   189 SVIIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIV----VHIRENGIEGE 249
            . .:.||.::.|.|..|:..|:.:|.:.|..|.|.|||:|||||.|||:|    :..:..|:.||
  Fly   178 P-YVDGLSQLAVTSYQDIDNLMTEGNKSRTVAATNMNAESSRSHAVFSVVLTQILTDQATGVSGE 241

  Fly   250 DMLKIGKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVDRA--------PHV 306
               |:.:::||||||||...|.| ..|.|::|..|||:||.|||.||:.|.|::        ..|
  Fly   242 ---KVSRMSLVDLAGSERAVKTG-AVGDRLKEGSNINKSLTTLGLVISKLADQSNGKKSGNDKFV 302

  Fly   307 PYRESKLTRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTV 371
            |||:|.||.||:::|||.::|.::|||||...:.|||||||.||.|||.|.|...||:....: :
  Fly   303 PYRDSVLTWLLKDNLGGNSRTVMVATISPSADNYEETLSTLRYADRAKRIVNHAVVNEDPNAR-I 366

  Fly   372 LKEYTEEIDKLKRDLMAARDKNGIYLAEETYGEITLKLESQNRELNEKMLLLKALKDELQNKEKI 436
            ::|...|::.|:..|..|        .....|::                     :|:|...|.:
  Fly   367 IRELRHEVETLRSMLKHA--------TGSPVGDV---------------------QDKLAESENL 402

  Fly   437 FSEVSMSLVE---KTQELKKTEENLLNTKGTLLLTKKVLTKTKRRY-------KEKKELVASHMK 491
            ..::|.:..|   ||:.::...:..|...|..:....:..:..:.|       ....||:..::|
  Fly   403 MKQISQTWEEKLVKTERIQNERQQALEKMGISVQASGIKVEKNKYYLVNLNADPSLNELLVYYLK 467

  Fly   492 TEQVL---TTQAQEILAAADLATDDTHQLHG----------TIERRRELDEKIR-------RSCD 536
            ...::   |...|:    .|:      ||.|          |||......|.::       .|..
  Fly   468 DRTLIGGRTISGQQ----PDI------QLSGLGIQPEHCVITIEDSGLYMEPVQGARCFVNGSAA 522

  Fly   537 QFKDRMQDNLEMIGGSLNLYQDQQAALKEQLSQEMVNSSYVSQRLALNSSKSIEMLKEMCAQSLQ 601
            ..|..:|:...::.|:.:.::                         :||.||..  ..|||...|
  Fly   523 VEKTPLQNGDRILWGNHHFFR-------------------------VNSPKSNN--TSMCASEPQ 560

  Fly   602 DQTNL--HNKLIGEVM--KISDQHSQAFVAKLMEQMQQ-QQLLMSKEIQ---------------- 645
            ....|  :|....|:|  ::|:...|..:|:|..|.:: :|:.:.|:.|
  Fly   561 TPAQLIDYNFARDEIMQNELSNDPIQTAIARLERQHEEDKQVALEKQRQEYERQFQQLRNILSPS 625

  Fly   646 ----------------------TNLQVIEENNQRHKAMLDSMQEKFATII---DSSLQSVEEHAK 685
                                  |:...:|:..|....|......:..|.|   :|.:|.....|:
  Fly   626 TPYAPYAPYDPLRMGKITPNTPTSQMRVEKWAQERDEMFRRSLGQLKTDIMRANSLVQEANFLAE 690

  Fly   686 QMHKKLEQLGAMSLPDAEELQNLQEELANERALAQQEDALLESMMMQMEQIKNLRSKNSISMSVH 750
            :|.||.:....:.:|.|....|      ..|.....|.|:|            ::..||.|....
  Fly   691 EMEKKTKFSVTLQIPPANLSPN------RRRGAFVSEPAIL------------VKRTNSGSQIWT 737

  Fly   751 LNKMEESRLTRNHRIDDIKSGIQDYQKLGIEASQSAQAE-----LTSQMEAGMLCLDQGVANCSM 810
            :.|:|       :::.|::...|::::..:.......|:     ..||....::    ||||. .
  Fly   738 MEKLE-------NKLIDMREMYQEHKERVLNGLDEDNAKPQDPFYESQENHNLI----GVANI-F 790

  Fly   811 LQVHMKNLNQKYE----KETNENVGSVRVHHNQVEIICQESKQ--QLEAVQEKTEVNLEQM---V 866
            |:|...::...|.    .:..|..|.::|   ::|.|..:..|  ..|:|.|.:..:.::.   |
  Fly   791 LEVLFHDVKLDYHTPIISQQGEVAGRLQV---EIERIAGQMPQDRMCESVSESSGDSRDEYDDPV 852

  Fly   867 DARQQLITEDRQRFIGHATV--ATDL-VQESNRQFSEHA--EHQRQQLQICEQELVRFQQSELKT 926
            |.....||       ...|:  |:.| :..||..|.::.  .||...:.:...|
  Fly   853 DPTSNQIT-------CRVTIKCASGLPLSLSNFVFCQYTFWGHQEMVVPVINAE----------- 899

  Fly   927 YAPTGTTPSKRDFVYPRTLVATSPHQEIVRRYRQELDWSDLDTTATIDE-----CSEGEHDVSM- 985
                                :|:..|.:|.::....|:     |.||:|     |.||...:.:
  Fly   900 --------------------STAHDQNMVFKFEHTQDF-----TVTINEEFLEHCIEGALSIEVW 939

  Fly   986 -HSVQELSETE 995
             |.....|:|:
  Fly   940 GHRSAGFSKTK 950

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	148/381 (39%)
		SMC_prok_B	<408..728	CDD:274008	66/395 (17%)
		SMC_prok_B	<651..>921	CDD:274008	57/291 (20%)
		Microtub_bind	923..>1004	CDD:464048	14/80 (18%)
Khc-73	NP_001261000.1	KISc_KIF1A_KIF1B	4..359	CDD:276816	146/378 (39%)
		Kinesin_assoc	356..468	CDD:465047	20/141 (14%)
		FHA_KIF13	446..547	CDD:438758	19/135 (14%)
		KIF1B	741..786	CDD:463574	6/55 (11%)
		DUF3694	989..1243	CDD:463599
		CAP_GLY	1785..1850	CDD:460154