DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp61F and Kif1a

DIOPT Version :9

Sequence 1:	NP_476818.1	Gene:	Klp61F / 38135	FlyBaseID:	FBgn0004378	Length:	1066	Species:	Drosophila melanogaster
Sequence 2:	XP_038940678.1	Gene:	Kif1a / 363288	RGDID:	1304996	Length:	1800	Species:	Rattus norvegicus

Alignment Length:	1089	Identity:	256/1089 - (23%)
Similarity:	441/1089 - (40%)	Gaps:	256/1089 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 NIQVYVRVRPLNSRE-----RCI--RSAEVVDVVGPREVVTRHTLDSKLTKKFTFDRSF----GP 72
            :::|.|||||.||||     :||  .|.....:|.|::       ..:..|.|:||.|:    .|
  Rat     5 SVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQ-------PKETPKSFSFDYSYWSHTSP 62

  Fly    73 E----SKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGI 133
            |    :.|..||..:...:::....|||..:|||||||.||::||:|.:        |.|.. ||
  Rat    63 EDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQ--------EKDQQ-GI 118

  Fly   134 IPRALSHLFDELRMM---EVEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSVIIQGL 195
            ||:....||..:...   .:.|::.:||:|:|.|.:.|||:..:...:|:.:....  ...::.|
  Rat   119 IPQLCEDLFSRINDTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLL--GPYVEDL 181

  Fly   196 EEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVV----HIRENGIEGEDMLKIGK 256
            .::.|.|.:|:..|::.|.:.|..|.|.||..|||||.||:|:.    |..|..|..|   |:.|
  Rat   182 SKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTE---KVSK 243

  Fly   257 LNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITAL--VDRAPH----------VPYR 309
            ::||||||||.....| .||.|::|..|||:||.|||:||:||  :|..|:          :|||
  Rat   244 ISLVDLAGSERADSTG-AKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKKTDFIPYR 307

  Fly   310 ESKLTRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKE 374
            :|.||.||:|:|||.::|:::|.:||...:.:||||||.||.|||.|:....:|:....| :::|
  Rat   308 DSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAIINEDPNNK-LIRE 371

  Fly   375 YTEEIDKLKRDLMAARDKNGIYLAEETYG--EITLKLESQNRELNEKMLLLKALKDELQNKEKIF 437
            ..:|:.:| |||:.|:....|.......|  ::|..|...:...:...|..:|......::..:|
  Rat   372 LKDEVTRL-RDLLYAQGLGDITDTNTVPGGPKLTNALVGMSPSSSLSALSSRAASVSSLHERILF 435

  Fly   438 SEVSMSLVEKTQELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEKKELVASHMKTEQVLTTQAQE 502
            :..|...:|:.:|                 |:|::.:....::||       ::..:.:..:.:.
  Rat   436 APGSEEAIERLKE-----------------TEKIIAELNETWEEK-------LRRTEAIRMEREA 476

  Fly   503 ILAAADLATDDTHQLHGTIERRRELDEKIRRSCDQFKDRMQDNLEMIGGSLNLYQDQQAALKEQL 567
            :||...:|                               |:::    ||:|.::..::......|
  Rat   477 LLAEMGVA-------------------------------MRED----GGTLGVFSPKKTPHLVNL 506

  Fly   568 SQEMVNSSYVSQRLALNSSKSIEMLKEMCAQSLQDQTNLHNKLIGEVMK------ISDQHSQAFV 626
            :::.:    :|:.|.......:..:....|:..||..     |.|..:|      .||.......
  Rat   507 NEDPL----MSECLLYYIKDGVTRVGREDAERRQDIV-----LSGHFIKEEHCIFRSDSRGGGEA 562

  Fly   627 AKLMEQMQQQQLLMSKEIQTNLQVIEENNQRHKAMLDSMQEKFATIIDSSLQSVEEHAKQMHKKL 691
            ...:|..:.....::.:..|...::...|:              .|:..|......|.:|..::.
  Rat   563 VVTLEPCEGADTYVNGKKVTEPSILRSGNR--------------IIMGKSHVFRFNHPEQARQER 613

  Fly   692 EQLGAMSLPDAEELQNLQEELANERALAQQEDALLESMMMQMEQIKNLRSKNSISMSVHLNKMEE 756
            |:......| ||.:         :.|.||:|  |||...:.|:|          .|...|.::|:
  Rat   614 ERTPCAETP-AEPV---------DWAFAQRE--LLEKQGIDMKQ----------EMEQRLQELED 656

  Fly   757 SRLTRNHRIDDIKSGIQDYQKLGIEASQSAQAELTSQMEAGMLCLDQGVANCSMLQVHMKNLNQK 821
                             .|::              .:.||..|...|.:...|.|:...|.::.:
  Rat   657 -----------------QYRR--------------EREEATYLLEQQRLDYESKLEALQKQMDSR 690

  Fly   822 YEKETNENVGSVRVHHNQVEIICQESKQQLEAVQEKTEVNLEQMVDARQQLITEDRQRFIGHATV 886
            |..|.||..              :|.:.:::..:.:.|:.|......:....|..|....|:|.
  Rat   691 YYPEVNEEE--------------EEPEDEVQWTERECELALWAFRKWKWYQFTSLRDLLWGNAI- 740

  Fly   887 ATDLVQESNRQFSEHAEHQRQQLQICEQELVRFQQSELKTYAPTGTTPSKRDFVYPRTLVAT--- 948
               .::|:|....|..:..:.|..:....|......:|   .|......:....:|||:||.
  Rat   741 ---FLKEANAISVELKKKVQFQFVLLTDTLYSPLPPDL---LPPEAAKDRETRPFPRTIVAVEVQ 799

  Fly   949 -----SPHQEIVRRYRQELDWSDLDTTATIDECSEGEHDVSMHSVQELSETET----IMNSTPIE 1004
                 :.|...:.:.||.||        .:.|..:...:|....|::.....|    ..:..|..
  Rat   800 DQKNGATHYWTLEKLRQRLD--------LMREMYDRAAEVPSSVVEDCDNVVTGGDPFYDRFPWF 856

  Fly  1005 PVDGVTVKRGCGTTRNSNSNALKPPVATGGKRSSSLSRSLTPSKT--SP 1051
            .:.|.:|..||.:....|:            ..|....:||||.|  ||
  Rat   857 RLVGSSVISGCNSYPLLNT------------CMSERMAALTPSPTFSSP 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	139/379 (37%)
		Kinesin	25..356	CDD:278646	135/364 (37%)
		Microtub_bind	923..>1009	CDD:290642	17/97 (18%)
Kif1a	XP_038940678.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	138/377 (37%)
		Kinesin_assoc	358..524	CDD:406567	33/230 (14%)
		FHA	501..605	CDD:238017	16/126 (13%)
		KIF1B	814..861	CDD:403579	9/54 (17%)
		DUF3694	1250..1406	CDD:403614
		PH_KIFIA_KIFIB	1681..1783	CDD:269939
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910