Protein Alignment Klp61F and Cenpe

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: XP_063138291.1
• Gene: Cenpe / 362044
• RGDID: 1307115
• Length: 2505
• Species: Rattus norvegicus
• Alignment Length: 1322
• Identity: 329/1322 - (24%)
• Similarity: 534/1322 - (40%)
• Gaps: 374/1322 - (28%)

  Fly    20 IQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHTLDSKLTKKFTFDRSFGPESKQCDVYSVVV 84
            :.|.||||||||||..:..|..:.....:..:    ..|...|.|.|||.|.......:||..:.
  Rat     7 VAVCVRVRPLNSREEELGEASHIYWKTDKNAI----YQSDGGKSFQFDRVFHSNETTKNVYEEIA 67

  Fly    85 SPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGIIPRALSHLFDELRMM- 148
            .|:|...:.|||.|:||||||.:||||||:|:|..           :|:||||:..:|..::..
  Rat    68 VPIISSAIQGYNGTIFAYGQTASGKTHTMMGSEDC-----------LGVIPRAIHDIFQRIKKFP 121

  Fly   149 EVEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSVIIQGLEEIPVHSKDDVYKLLEKG 213
            |.|:.:|:||:|:|||.:.|||......|..|..:...: :|.:..|.|..|::.:...|.|..|
  Rat   122 EREFLLRVSYMEIYNETITDLLCNTQKVKPLIIREDINR-NVYVADLTEEVVYTAEMALKWLATG 185

  Fly   214 KERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEG--EDMLKIGKLNLVDLAGSENVSKAGNEKG 276
            ::.|....|.||.:||||||:|.:::..||.....  :..:|:..||||||||||..::.|.| |
  Rat   186 EKNRHYGITKMNQRSSRSHTIFRMILESREKAESSNCDGSIKVSHLNLVDLAGSERAAQTGAE-G 249

  Fly   277 IRVRETVNINQSLLTLGRVITALVDR--APHVPYRESKLTRLLQESLGGRTKTSIIATISPGHKD 339
            :|::|...||::||.||:||..|.|.  ...:.||:|||||:||.||||..||.||.||:|.  .
  Rat   250 MRLKEGCYINRNLLILGQVIKKLSDGQVGGFINYRDSKLTRILQNSLGGNAKTRIICTITPA--S 312

  Fly   340 IEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEY----------------------------- 375
            ::|||:||::|..||.::|.|.||:....:.:||.|
  Rat   313 LDETLTTLQFASTAKYMKNTPYVNEVSNDEALLKRYRREIVDLKKQLEEVNTKTRAQEIEKDQLA 377

  Fly   376 -------------TEEIDKLKRDLMAA------------------------RDKNGI-------- 395
                         .|:|..|||.|:.:                        :|.|.:
  Rat   378 QLLDEKDLLQKVQDEKIQNLKRMLVTSSSIALQQELEIKKKRRVTWCFGKMKDSNYVKEFKIPTN 442

  Fly   396 --------------------------------------------------YLAEET--------- 401
                                                              .|:||.
  Rat   443 ITTRTRKTSVTPLRENSLMKLGESALSWESEVFDNTLEPLAEAEWSSATALLSEENLESELTSLN 507

  Fly   402 --YGEITLKLESQNRELNEKMLLLKALKDEL-------QNKEK-----IFSEVS--MSLVEKTQE 450
              |..:.|..|...|| ||.:.|....|:||       |.:||     :..|||  .:|::..:|
  Rat   508 TQYNNLVLDYEQLRRE-NEDLKLKLKEKNELEEFEFLEQREEKDQELQLMHEVSNLKNLIKHAEE 571

  Fly   451 LKKTEENLLNTKGTLLLTKKVLTKTKRRY--KEKKELVASHMKTEQVLTTQAQEIL--AAADLAT 511
            ..:..||.|::|..||..|:...|..:||  .:|.|..    ||:...:::|.|.|  |...|:.
  Rat   572 YNQDLENELSSKVELLKEKEDQIKELQRYIDAQKSETT----KTDLSYSSEATEDLKQAMRTLSD 632

  Fly   512 DDTHQLHGTIE------RRRELDEKIRRSCDQFKDRMQDNLEMIGGSLNLYQDQQAALKEQLS-- 568
            .||..|....|      ...||.|:|....|..| :|::.::|....|...:..||.|:::|.
  Rat   633 LDTVALDAKRESAFLRSENLELKERINELSDSCK-QMENGIQMYQRQLEAKKQVQADLEKELQLA 696

  Fly   569 -QE------------MVNSSYVSQRLA-----LNS--------SKSIEMLKEMCAQSLQDQT--- 604
             ||            ::::..:.:|:.     ||.        .|.:.:|.|:.:...:.:|
  Rat   697 FQEISKLSALVDGKGLLSNLELEKRITDLQKELNKEVEEKETLQKEVHLLSELKSLPSEVETLRR 761

  Fly   605 NLHNK---------------------------LIGEV-------------MKISDQHSQAFVAKL 629
            .||.|                           |:.|:             .:.||:..||..:..
  Rat   762 ELHEKSEELCVITTEREKLFSEMAHKDSRIQGLLEEIGNTKDDLAASQLSQRSSDEECQALKSLH 826

  Fly   630 ME-QMQQQQLL-----MSKEIQTNLQVIEENNQRHKAMLDSMQEKFATI--IDSSLQSVEEH--- 683
            :| :.:|:::|     :.:|:....|.:.:.....:.||:.|:|....:  .||||||.|:.
  Rat   827 VELKHRQEEVLEESERVKQELSQKTQELAQKTAEGQEMLNQMEELREKLERRDSSLQSAEKEKNL 891

  Fly   684 -AKQMHKKLEQLGAMSLPDAEELQNLQEELANER-------------ALAQQEDAL--LESMMMQ 732
             .:::.:.||::.|:: .:..:|:.|||.|..||             .:..||..|  |||:...
  Rat   892 LTEKLQQTLEEVRALT-QEKNDLKQLQESLQTERDQLRSDIQDTVNMNIDTQEQLLNALESLKQH 955

  Fly   733 MEQIKNLRSKNSISMSVHL---------------------------------------NKMEESR 758
            .|.|..|:.|.:..||.||                                       .:.||.|
  Rat   956 QETINMLKMKATEEMSDHLPIKGREGSSDEVEQKLDGIDEENLLAESAHTVVGSGEDHGETEEQR 1020

  Fly   759 -----LTRNHRIDD-IKSGIQDYQKLGIEASQSAQAELTSQMEAGMLCLDQGVANCSMLQVHMKN 817
                 |..|.|:.. ::|.|.:.::|.::..::.:..:.:|.|..:| .|:       |:...:.
  Rat  1021 KIDSLLQENSRLQQTLESIIAEKEQLKMDLKENIEMSVENQEELRIL-RDE-------LKRQQEI 1077

  Fly   818 LNQKYEKETNENVGSVRVHHNQVEI---------ICQESKQQLEAVQEKTEVNLEQMVDARQQLI 873
            ..|:.:..|.::....|.|....||         ..||::|||.::||... .::..|...:.|.
  Rat  1078 AAQEKDHVTEKSEELSRAHERLAEIEEKLKEKNQKLQETQQQLVSIQEAMS-EMQAKVTDLENLQ 1141

  Fly   874 TEDRQRFIGHATVAT---DLVQESNRQFSEHAEHQRQQLQICE-QELVRFQQSELKTYA----PT 930
            .|.|.:.:....|.|   :|.|:.:..:.:.....:::..:.| ||....::.:||.||    ..
  Rat  1142 NEFRNQALALERVETERLELAQKLHENYEKMESITKERNDLKELQESFEIEKKQLKEYAREMESA 1206

  Fly   931 GTTPSKRDFVYPRTLVATSPHQEIVRRYR-----QELDWSDLDTTATIDECSEGEHDVSMHSVQE 990
            |....::..:....|   ..:|||::..|     :|...|....|...:..|:||..|...  ||
  Rat  1207 GLQTKEQLNIAHANL---KEYQEIIKELRGSISEKEAQASSTQDTGKTNPASQGETPVPRE--QE 1266

  Fly   991 -LSETETIMNS----TPIEPVD 1007
             |.:.|....|    :.:|||:
  Rat  1267 LLPDAEEARASAEKGSELEPVE 1288

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	139/349 (40%)
		SMC_prok_B	<408..728	CDD:274008	101/441 (23%)
		SMC_prok_B	<651..>921	CDD:274008	73/348 (21%)
		Microtub_bind	923..>1004	CDD:464048	22/94 (23%)
Cenpe	XP_063138291.1	None