Protein Alignment Klp61F and Kif20a

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: NP_001101896.1
• Gene: Kif20a / 361308
• RGDID: 1307695
• Length: 888
• Species: Rattus norvegicus
• Alignment Length: 920
• Identity: 208/920 - (22%)
• Similarity: 382/920 - (41%)
• Gaps: 282/920 - (30%)

  Fly     3 ISGGNTSRQ-PQKKSNQNIQVYVRVRPLNSRER---------CIRSAEVVDVVGPREVVTRHTLD 57
            ||.....:| |.:.:.:.::||:|:||..:.|.         ||.:.|.:.:..|::.....:.:
  Rat    46 ISASLEDKQAPMEDTAEKMKVYLRIRPFLTSELERQEDQGCVCIENTETLLLQAPKDSFALKSNE 110

  Fly    58 ---SKLTKKFTFDRSFGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETA 119
               .:.|.||||.:.||||..|...:::.:..::::||.|.|..::.||.|.:|||:|:.|.
  Rat   111 RGIGQATHKFTFSQIFGPEVGQVSFFNLTMKEMVKDVLRGQNWLIYTYGVTNSGKTYTIQGT--- 172

  Fly   120 ELKSSWEDDSDIGIIPRALSHLFDELR-------------------------------------- 146
                    ..|:||:|::|:.:|:.|:
  Rat   173 --------SKDVGILPQSLALIFNSLQGQLHPTPDLKPLLSNEVIWLDSKQIRQEEIKKLSLLIG 229

  Fly   147 ---------------------------------------------------------------MM 148
                                                                           ..
  Rat   230 GLQEEELSTSLKKRVHAESRIGASNSFDSGIAGLSSTSQFTSSSQLDETSQLWAQPDTVPVSVPA 294

  Fly   149 EVEYTMRISYLELYNEELCDLLSTDD----TTKIRIFDDSTKKGSVIIQGLEEIPVHSKDDVYKL 209
            ::.:::.||:.|:|||.|.|||....    ...:|:.:|  :.|:..::.|..|.|...::.:||
  Rat   295 DIRFSIWISFFEIYNELLYDLLEPPSHQHKRQTLRLCED--QNGNPYVKDLNWIHVRDVEEAWKL 357

  Fly   210 LEKGKERRKTATTLMNAQSSRSHTVFSI-VVHIRENGIEGEDMLKIGKLNLVDLAGSENVSKAGN 273
            |:.|::.:..|:|.||..|||||::||| ::|::.   ||:.:.||.:|:|.||||||....  .
  Rat   358 LKVGRKNQSFASTHMNQHSSRSHSIFSIRILHLQG---EGDIVPKISELSLCDLAGSERCKH--Q 417

  Fly   274 EKGIRVRETVNINQSLLTLGRVITALVDRAPH------VPYRESKLTRLLQESLGGRTKTSIIAT 332
            :.|.|::|..|||.||.||||.|.||.....:      :|:|:|||||:.|....||.::.:|..
  Rat   418 KSGERLKEAGNINTSLHTLGRCIAALRQNQQNRSKQNLIPFRDSKLTRVFQGFFTGRGRSCMIVN 482

  Fly   333 ISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKL-TKKTVLKEYTEEIDK-LKRDLMAARDKNGI 395
            ::|.....:|||...:::..|..:.:.|.|:..: :..:.:||::.::.. ||::..|..|...
  Rat   483 VNPCASTYDETLHAAKFSALASQLVHAPPVHLGIPSLHSFIKEHSLQVSPGLKKEGKADSDLED- 546

  Fly   396 YLAEETYGEITLKLESQNRELNE--KMLLLKALKDELQNKEKIFSEVSMSLVEKTQELKKTEENL 458
              :.|...:|::..:.:..::.|  |.||||..:::||.:.::..|:...:||:.|:.::.....
  Rat   547 --SPEDEADISMYGKEELLQVVEAMKALLLKERQEKLQLEIQLREEICNEMVEQMQQREQWCSER 609

  Fly   459 LNTKGTLLLTKKVLTKTKRRYKEKKELVASHMKTEQVLTTQAQEILAAADLATDDTHQLHGTIER 523
            |:|:..||         :..|::|.:::      ::.|||..||.:
  Rat   610 LDTQKDLL---------EELYEDKLKIL------KESLTTFYQEQI------------------- 640

  Fly   524 RRELDEKIRRSCDQFKDRMQDNLEMIGGSLNLYQD--QQAALKEQLSQEMVNSSYVSQRLALNSS 586
             :|.||||            :.||      .|.|:  ||...::....|:  |...|||||  :|
  Rat   641 -QERDEKI------------EELE------TLLQEAKQQPVAQQSGGCEL--SLRRSQRLA--AS 682

  Fly   587 KSIEMLKEMCAQSLQDQTNLHNKLIGEVMKISDQHSQAFVAKLMEQMQQQQLLMSKEIQTNLQVI 651
            .|.:.|:|:.|:..|.:|.|.:.                .|:|
  Rat   683 ASSQQLQEVKAELEQCKTELGST----------------TAEL---------------------- 709

  Fly   652 EENNQRHKAML--DSMQEKFATIIDSSLQSVEEHAKQMHKKLEQLGAMSLPDAEE-------LQN 707
                |:::.||  ....:.|...:|..|:..:::.:.:..:|::|| .||..||.       ...
  Rat   710 ----QKYQQMLKPPPTAKPFTIDVDKKLEEGQKNIRLLRTELQELG-QSLQSAERACCHSTGAGK 769

  Fly   708 LQEELAN-ERALAQQEDALLE---SMMM--------------QMEQIKNLRSKNSISMSVHLNKM 754
            |::.|.| :..|.:|...|.|   :||:              |.:.:..|:.:.|....:..|:.
  Rat   770 LRQALTNCDDILIKQNQTLAELQNNMMLVKLDLQKKAACIAEQYQTVLKLQGQASAKKRLGANQE 834

  Fly   755 EESRLTRNHR 764
            .:.   .||:
  Rat   835 NQQ---PNHQ 841

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	117/471 (25%)
		SMC_prok_B	<408..728	CDD:274008	71/336 (21%)
		SMC_prok_B	<651..>921	CDD:274008	28/141 (20%)
		Microtub_bind	923..>1004	CDD:464048
Kif20a	NP_001101896.1	KISc_KIF23_like	62..504	CDD:276819	114/459 (25%)
		SMC_prok_B	<560..817	CDD:274008	74/356 (21%)
		RBD_KIF20A	601..656	CDD:409645	19/107 (18%)