Protein Alignment Klp61F and Kif14

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: NP_001414162.1
• Gene: Kif14 / 360849
• RGDID: 1310650
• Length: 1672
• Species: Rattus norvegicus
• Alignment Length: 1257
• Identity: 303/1257 - (24%)
• Similarity: 509/1257 - (40%)
• Gaps: 332/1257 - (26%)

  Fly     7 NTSRQPQ--KKSNQNIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHTLDSKLTKKFTFDRS 69
            ||..:|.  |..|..:.|.|||||.:.||:..::::||...| .|:...|. |.|....|.:|.:
  Rat   379 NTFTEPDSLKVENSQVTVAVRVRPFSKREKTEKASQVVFRNG-EEITVEHP-DMKQIYSFIYDVA 441

  Fly    70 FGP-------ESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVG-NETAELKSSWE 126
            |..       .:.|..||..:.:||::....|||..:|||||||:||::||:| ||
  Rat   442 FWSFDECHPGYANQTTVYETLAAPLLDRAFEGYNTCLFAYGQTGSGKSYTMMGLNE--------- 497

  Fly   127 DDSDIGIIPRALSHLFDEL---RMMEVEYTMRISYLELYNEELCDLL-----STDDTTKIRIFDD 183
               :.|||||....||.::   :..||.|.:.:|:.|:|||::.|||     :......:|:.:.
  Rat   498 ---EPGIIPRFCEDLFAQIAKKQASEVSYHLEMSFFEVYNEKIHDLLVCKGENGQRKQPLRVREH 559

  Fly   184 STKKGSVIIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVV-HIRENGIE 247
            ..  ....::||....|.|..|:...||.|.::|.||.|.||.:|||||:||::|: ..:...:|
  Rat   560 PV--SGPYVEGLSMNVVSSYSDIQSWLELGNKQRATAATGMNDKSSRSHSVFTLVMTQTKTEFVE 622

  Fly   248 GE--DMLKIGKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVDRA----PHV 306
            ||  |.....::||:||||||..|.| :..|.|::|.|:||:||||||:||:||.::|    ..:
  Rat   623 GEEHDHRITSRINLIDLAGSERCSTA-HSSGERLKEGVSINKSLLTLGKVISALSEQANGKRVFI 686

  Fly   307 PYRESKLTRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTV 371
            |||||.||.||:|||||.:||::||||||...:||||||||.||.:|:.|.|..:||:.:..| :
  Rat   687 PYRESTLTWLLKESLGGNSKTAMIATISPAASNIEETLSTLRYATQARLIVNVAKVNEDMNAK-L 750

  Fly   372 LKEYTEEIDKLKRDLMAAR--DKNGIYLAEETYGEITLKLESQNRELNEKMLLLKALKDELQNKE 434
            ::|...||:|||....::|  |.....|..:....:.:||..|.|::.|   :.:..|::.:..|
  Rat   751 IRELKAEIEKLKAAQKSSRNIDPERYRLCRQEISSLRMKLHQQERDMAE---IQRVWKEKFEQAE 812

  Fly   435 KIFSEVSMSLVEKTQELKKTE---------ENLLNTKGTLLLTKKVLTKTKRRYKEKKELVASHM 490
            |       ..:::|:||:|..         .||:|......|::.:|...    ||....|..|
  Rat   813 K-------RKLQETKELQKAGVTFQMDNHLPNLVNLNEDPQLSEMLLYMV----KEGITTVGKH- 865

  Fly   491 KTEQVLTTQAQEILAAADLATDD---THQLHGTI------ERRRELD-------------EKIRR 533
                 ....:.:|..:..|..||   .....||:      |.:..::             :::..
  Rat   866 -----TPNSSHDIQLSGVLIADDHCTIRSYGGTVSIVPAGEAKTYVNGMHISEPTVLHHGDRVVL 925

  Fly   534 SCDQF------------KDRMQDNLEMIGGSLNLYQDQQ--AALKEQLSQEMVNSSYVSQRLALN 584
            ..|.:            |...::||...|.....:...:  ||.:.:|..|:.::...::.   .
  Rat   926 GGDHYFRFNHPVEVQKGKKTSRNNLTSEGPKDFEFAKNELLAAQRSRLEAEIKDAQLKAKE---E 987

  Fly   585 SSKSIEMLKEMCAQSLQDQTNLH-NKLIGEVMKISDQHSQAFVAKLMEQMQQQQL--LMSKEIQT 646
            ..:.|::.|||..|.|..|...: ||:            :|..|:|.|:.|:::|  :.:::...
  Rat   988 MMQGIQIAKEMAQQELSSQRAAYENKI------------RALEAELREESQRKRLEEINNQKASH 1040

  Fly   647 NLQVIEENNQR-------HKAMLDSMQEKFATIIDSSLQSVEEHAKQMHKKLEQLGAMSLPDAEE 704
            .::.:|:..|.       :|..|:  .|..||     .|::|:|..:..:.||.|.......|||
  Rat  1041 KIEELEKAKQHLEQEVYVNKRRLE--METLAT-----KQALEDHRIRHARILEALEREKQKIAEE 1098

  Fly   705 LQNLQEELANER---------------ALAQQEDAL----------------------------- 725
            :|.|||...|..               .:.|:.:|:
  Rat  1099 VQILQENRGNRNKTFTIQPNWSSMKLSTMIQEANAISDKFKKHYVFGRHDASDKGRSDPSVRVRN 1163

  Fly   726 ----------LESMMMQMEQIKNLRSKNS-------------------ISMSV-HLNKMEESRLT 760
                      ||....::..:|:|...||                   .|..| .|::.....|.
  Rat  1164 LQLGISTFWNLEKFESKLAAMKDLYESNSGTRGEDVFCDPEDEWEPDITSTPVSSLSRRRSRSLM 1228

  Fly   761 RNHRIDDIKSGIQDYQKL------GIEASQSAQAELTSQMEAGMLC------------------- 800
            :|.|:......|...|.:      |:....|.....:|:.....:|
  Rat  1229 KNRRVSGCLHDIHPIQSMHPSHTSGLMEKPSTIYSNSSESFLPGICKELIGSSIDFLGQSFDEEK 1293

  Fly   801 --LDQGVANCSMLQ---VHMKNLNQKYEKETNENVGSVRVHHN-QVEIIC--------------- 844
              .|..:.|...|.   :.:...:::.::|:.:||.|.|.... .:::.|
  Rat  1294 TIADSLINNLLKLYNGVIAISKAHEEQDEESQDNVFSDRAAQALTIQVACAFEQLVVLFKHWLDD 1358

  Fly   845 -----------QESKQQLEAVQEKTEV-------NLEQMVDARQQLITEDRQRFIGHATVATDL- 890
                       :|.:|.::.:....::       ::..||...|..:||..|:.:||......|
  Rat  1359 FPPCSGSARLEEELRQDIKKLGGYLQLFLQGCCSDISSMVKEAQNKVTEIIQQAVGHVAQLAVLK 1423

  Fly   891 ------VQESNRQFSEHAEHQRQQLQICEQELVRFQQSELKTYAPTGTTPSKRDFVYPRTLVATS 949
                  :::||:..|             .|||:...|.        ||....|..:......|..
  Rat  1424 GSKLCVLEDSNKVSS-------------AQELMAALQD--------GTASGMRSLLDSGLETAQE 1467

  Fly   950 PHQEIVRRYRQE---------------------LDWSDLDTTATIDECSEGEHDVSMHSVQELSE 993
            ..|::.|:...|                     .:|........::|.|..:....::...|..:
  Rat  1468 LRQDVSRQSAPEEVTRQMKANAVELVGSLENIFAEWRTKSFRTQVEEGSRQQGSKVLNLASEFLK 1532

  Fly   994 TETIMNSTPIEPVDGVTVKRGC 1015
            .::.:..| ||.|  |:..|||
  Rat  1533 LKSCLQQT-IEMV--VSALRGC 1551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	150/370 (41%)
		SMC_prok_B	<408..728	CDD:274008	76/428 (18%)
		SMC_prok_B	<651..>921	CDD:274008	67/421 (16%)
		Microtub_bind	923..>1004	CDD:464048	12/101 (12%)
Kif14	NP_001414162.1	None