DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp61F and cos

DIOPT Version :9

Sequence 1:	NP_476818.1	Gene:	Klp61F / 38135	FlyBaseID:	FBgn0004378	Length:	1066	Species:	Drosophila melanogaster
Sequence 2:	NP_001260765.1	Gene:	cos / 35653	FlyBaseID:	FBgn0000352	Length:	1201	Species:	Drosophila melanogaster

Alignment Length:	1154	Identity:	232/1154 - (20%)
Similarity:	429/1154 - (37%)	Gaps:	318/1154 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 VGPREVVTRHTLDSKLTKKFTFDRSFGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGK 109
            |||..|...|.|.|              .|.|..||...|.|||...|.|::.:|..|||.|.||
  Fly   131 VGPHTVPVTHALPS--------------SSSQEQVYHQTVFPLITLFLEGFDASVVTYGQRGQGK 181

  Fly   110 THTMVGNETAELKSSWEDDSDIGIIPRALSHLFDELRM-MEVEYTMRISYLELYNEELCDLLSTD 173
            ::|:.||    ::.....||..|::...:..:|..:.: .|..|.:.:.::|:...::||||
  Fly   182 SYTLYGN----VQDPTLTDSTEGVVQLCVRDIFSHISLHPERTYAINVGFVEICGGDVCDLL--- 239

  Fly   174 DTTKIRIFDDSTKKGSVIIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIV 238
                                |:..|...:.|.|:..|:.|...|         ||..:||:|::.
  Fly   240 --------------------GMGNIHCTNVDAVFHWLQVGLSAR---------QSLPAHTLFTLT 275

  Fly   239 VHIRENGIEGEDML--KIGKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVD 301
              :.:..:..|.:|  ::...:..||.|:|   :.|::...|     .::..|..|.:||:.|.|
  Fly   276 --LEQQWVSKEGLLQHRLSTASFSDLCGTE---RCGDQPPGR-----PLDAGLCMLEQVISTLTD 330

  Fly   302 RA------PHVPYRESKLTRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKP 360
            ..      .::||.::.||.||::|.|||.:|.:|..:||..:.:.|||..|::|.:.:.::|..
  Fly   331 PGLMYGVNGNIPYGQTTLTTLLKDSFGGRAQTLVILCVSPLEEHLPETLGNLQFAFKVQCVRNFV 395

  Fly   361 EVNQKLTKKTVLKEYTEEIDKLKRDL-----MAARDKNGIYLAEETYGEITLKLESQNRELNEKM 420
            .:|......|::.:..|.:.:.....     ....|..|:..|...:.::....|.
  Fly   396 IMNTYSDDNTMIVQPAEPVPESNSSAGPLSQAGPGDNFGLQFAASQWSKLVTNAEG--------- 451

  Fly   421 LLLKALKDELQNKEKIFSEVSMSLVEKTQELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEKKEL 485
             |...|.|     .|:.:||....:|:...||:..|..|::           |:..|:.|:...:
  Fly   452 -LFSKLID-----SKLITEVEKEQIEEWLFLKQECEECLSS-----------TEAMRQQKQLVPI 499

  Fly   486 VASHMKTEQVLTTQAQEILAAADLATDDTHQLHGTIERRRELDEKIRRSCDQFKDR-----MQDN 545
            :.:. :.|.|.:..|......:|...|..::.|     |.:||:||....::|:|:     ::.:
  Fly   500 LEAE-EPEDVNSEAANSESPNSDNENDTDNESH-----RPDLDDKIESLMEEFRDKTDALILEKH 558

  Fly   546 LEMIGGSLN-LYQDQQAALKEQLSQEMVNSSYVS----------------------QRLA----- 582
            .|.:..... :.|.|...::.|..:|..:...||                      .|:|
  Fly   559 AEYLSKHPKAVMQSQDREIEAQPPEENGDDRKVSIGSRRRSVQPGASLSTAELAMLNRVASQQPP 623

  Fly   583 -----------LNSSKS----------------IEML-------------KEMCAQSLQDQTNLH 607
                       |.||..                ||.|             |:...:.:::...:.
  Fly   624 PPIDPESVVDPLESSSGEGIRQAALAAAAATAPIEQLQKKLRKLVAEIEGKQRQLREIEETIQVK 688

  Fly   608 NKLIGEVMKISDQHSQAFVAKLMEQMQQQQLLMSKEIQTNLQVIEENNQRHKAML----DSMQEK 668
            ..:|.|::|.||..|.|           :|....|..:...:..:...|..||::    .|..|:
  Fly   689 QNIIAELVKNSDTRSHA-----------KQRFHKKRAKLEAECDKAKKQLGKALVQGRDQSEIER 742

  Fly   669 FATIID---------SSLQSVEEHAKQMHKKLEQLGAMSLPDAEELQNLQEELANERALAQQEDA 724
            :.|||.         ||::.:...:.|..|||:|....|...|::   ||::|..|..|..|.:|
  Fly   743 WTTIIGHLERRLEDLSSMKHIAGESGQKVKKLQQSVGESRKQADD---LQKKLRKECKLRCQMEA 804

  Fly   725 LLESMMMQMEQIKNL-RSKNSISMSVHLNKMEESRLTR-NHRIDDIKSGIQDYQKLGIEASQSAQ 787
            .|..:....|..|.| :::.|........|..::|:|. ||.:.:....::  ::.|.|..::.:
  Fly   805 ELAKLRESRETGKELVKAQGSPEQQGRQLKAVQARITHLNHILREKSDNLE--EQPGPEQQETLR 867

  Fly   788 AELTSQMEAGMLCLDQGVANCSMLQVHMKNLNQKYEKETNENVGSVRVHHNQVEIICQESKQQLE 852
            .|:.:......|.|::   .|        :|::|.:::               :::.|:.:::|.
  Fly   868 HEIRNLRGTRDLLLEE---RC--------HLDRKLKRD---------------KVLTQKEERKLL 906

  Fly   853 AVQEKTEVNLEQMVDARQQLITEDRQRFIGHATVATDLVQESNRQFSEHAEHQRQQLQICEQELV 917
            ...|..|. ::..::.:.::||       ||.::.|     |:|...|..|      |:....|.
  Fly   907 ECDEAIEA-IDAAIEFKNEMIT-------GHRSIDT-----SDRIQREKGE------QMLMARLN 952

  Fly   918 RFQQSELKT--YAPTGTTPSKRDFVYPRTLVATSPHQEI----VRRYRQELDWSDLDTTATIDEC 976
            |....|::|  |.........||         :|...|:    :.|.|...:|.:...:..:.:.
  Fly   953 RLSTEEMRTLLYKYFTKVIDLRD---------SSRKLELQLVQLERERDAWEWKERVLSNAVRQA 1008

  Fly   977 S-EGE---------HDVSM-----HSVQELSETETIMNSTPIEPVDGVTVKRGCGTTRNSNSNAL 1026
            . |||         |::.:     |..:|.|.:........:.|.                  .:
  Fly  1009 RLEGERNAVLLQRQHEMKLTLMLRHMAEETSASSASYGERALAPA------------------CV 1055

  Fly  1027 KPPVAT------------GGKRSSSLSRSLTPSKTSPRGSPAFVRHNKE 1063
            .|||..            ||..|.:|.::   .|..|.||......:||
  Fly  1056 APPVQASSDFDYDHFYKGGGNPSKALIKA---PKPMPTGSALDKYKDKE 1101

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	85/328 (26%)
		Kinesin	25..356	CDD:278646	83/319 (26%)
		Microtub_bind	923..>1009	CDD:290642	18/106 (17%)
cos	NP_001260765.1	Motor_domain	132..389	CDD:277568	82/316 (26%)
cos	NP_001260765.1	SPEC	657..856	CDD:295325	47/214 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437861
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930