DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Klp61F and klp-20

DIOPT Version :9

Sequence 1:	NP_476818.1	Gene:	Klp61F / 38135	FlyBaseID:	FBgn0004378	Length:	1066	Species:	Drosophila melanogaster
Sequence 2:	NP_497178.1	Gene:	klp-20 / 3565057	WormBaseID:	WBGene00002230	Length:	646	Species:	Caenorhabditis elegans

Alignment Length:	731	Identity:	215/731 - (29%)
Similarity:	348/731 - (47%)	Gaps:	172/731 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 QNIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHTLDSKLTKK----------FTFDRSFGP 72
            :.::|.||.||:::.|:         :.|.:..||.:..:..:..|          |.||..|.|
Worm     5 EKVKVVVRCRPISTTEK---------LQGHKIAVTCNDEEKAVNIKSLSQEDPPRTFYFDAVFSP 60

  Fly    73 ESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGN-ETAELKSSWEDDSDIGIIPR 136
            .:.|..||:|...|::|.||.|||.|:|||||||||||.||.|: |..|::         ||||.
Worm    61 NTDQMTVYNVAARPIVENVLKGYNGTIFAYGQTGTGKTFTMAGDLEPVEMR---------GIIPN 116

  Fly   137 ALSHLFDELRMMEVEYT--MRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSVIIQGLEEIP 199
            :.:|:||.:...:.:.|  :|:||||:||||:.||||.|....:.|  .......|.::.|....
Worm   117 SFAHIFDHIAKCQHDTTFLVRVSYLEIYNEEIRDLLSKDHNGNLEI--KERPDVGVYVRNLSNPT 179

  Fly   200 VHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIGKLNLVDLAG 264
            |.:...:..|:|.|.:.||...|.||.:|||||.:|::.:....||:..:     |||.||||||
Worm   180 VENASKMQALMEFGSKNRKVGATAMNLESSRSHAMFTVTIESCRNGLVTQ-----GKLQLVDLAG 239

  Fly   265 SENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVD-RAPHVPYRESKLTRLLQESLGGRTKTS 328
            ||..||.| .:|.|::|...||.||.|||.||::||| ::.|:|||.||||||||:||||.:||.
Worm   240 SERQSKTG-AQGERLKEAAKINLSLSTLGNVISSLVDGKSTHIPYRNSKLTRLLQDSLGGNSKTV 303

  Fly   329 IIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLKRDLMAARDKN 393
            :||.:.|...:.:||||||.||:|||||||..::|:. .|...|:::..||:.|::
Worm   304 MIANVGPATYNYDETLSTLRYANRAKNIQNVAKINED-PKDAQLRKFQLEIEALRK--------- 358

  Fly   394 GIYLAEETYGEITLKLESQNRELNEKMLLLKALKDELQNKEKIFSEVSMSLVEKTQELKKTEENL 458
              .|.||..|:...:.|:...::.|:.:       |::.|.||       |.|:.......||
Worm   359 --ILDEENPGDDENQEEAWEAKMQEREV-------EMEKKRKI-------LEERVNSAVNDEE-- 405

  Fly   459 LNTKGTLLLTKKVLTKTKRRYKEKKELVASHMKTEQVLTTQAQEILAAADLATDDTHQLHGTIER 523
                                         :|...::::..:|:                   :::
Worm   406 -----------------------------THRLVKEMMENEAE-------------------LKK 422

  Fly   524 RRELDEKIRRSCDQFKDRMQDNLEMIGGSLNLYQ--DQQAALKEQLSQEMVNSSY--VSQRLALN 584
            .|...||:|...::.:.::     ::||. ||.:  ::||.|.|..::|:..|.:  ...|..|.
Worm   423 ARSEHEKLRSKLEKIEKKL-----IVGGE-NLLEKVEEQAKLLEVNNKELEQSKFQEAHLRTQLE 481

  Fly   585 SSKSIEMLKEMCAQSLQDQTNLHNKLIGEVMKISDQHSQAFVAKLMEQMQQQQLLMSKEIQTNLQ 649
            ...::::..|....|||::..:.:|   ::.|:|::                    .|:.:..|:
Worm   482 ERTAVKVEIEERYSSLQEEAFVKSK---KIKKVSNE--------------------LKDARAELK 523

  Fly   650 VIEENNQRH-KAMLDSMQE------------------KFATIIDSSLQSVEEHAKQMHKKLEQLG 695
            .:||::||. :||||.:::                  :...:|:..:...|||.....|.:...|
Worm   524 DLEEDHQRQVEAMLDDIRQLRKELLLNIAIIDEYIPVEHVELIEKYVSWSEEHGDWQLKAIAYTG 588

  Fly   696 ----AMSLPDAEELQN 707
                |.:.|..:|..|
Worm   589 NNMRASAPPAKKEFSN 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	151/360 (42%)
		Kinesin	25..356	CDD:278646	144/344 (42%)
		Microtub_bind	923..>1009	CDD:290642
klp-20	NP_497178.1	Motor_domain	5..331	CDD:328930	146/351 (42%)
klp-20	NP_497178.1	SMC_N	<325..>569	CDD:330553	64/348 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4221
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940