DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp61F and neb

DIOPT Version :9

Sequence 1:	NP_476818.1	Gene:	Klp61F / 38135	FlyBaseID:	FBgn0004378	Length:	1066	Species:	Drosophila melanogaster
Sequence 2:	NP_476817.1	Gene:	neb / 35293	FlyBaseID:	FBgn0004374	Length:	1121	Species:	Drosophila melanogaster

Alignment Length:	1130	Identity:	285/1130 - (25%)
Similarity:	472/1130 - (41%)	Gaps:	307/1130 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 NIQVYVRVRPLNSRERCIRS--AEVVDVVGPREVVTRHTLDSK-----LTKKFTFDR---SFGPE 73
            |:.|.|||||||:.| |.|.  ..||.|.|....:|.....|.     :|..|::|:   |..||
  Fly   120 NMIVAVRVRPLNALE-CTRGQVTNVVQVHGNSNELTVQAGSSADASAGVTHFFSYDQVYYSCDPE 183

  Fly    74 SK----QCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDS----- 129
            .|    |..|:.....|||:....|||..:|||||||:||:::|:|.|..       ||:
  Fly   184 RKNFACQAKVFEGTARPLIDTAFEGYNACLFAYGQTGSGKSYSMMGIEAL-------DDAALDGG 241

  Fly   130 ----DIGIIPRALSHLFDELR----MMEVEYTMRISYLELYNEELCDLLS-------TDDTTKIR 179
                :.|||||....||..:.    ..:::..:.:||.|:|||::.||||       |.::|.|:
  Fly   242 PPHDEAGIIPRFCHELFRRIEAVKSQQQLQVEVEVSYFEIYNEKIHDLLSVQHAAAATGESTPIQ 306

  Fly   180 ----------------IFDDSTKKGSVIIQGLEEIPVHSKDDVYKL---LEKGKERRKTATTLMN 225
                            ||      |..::    ::..||.|....|   |..|..:|.||:|.||
  Fly   307 QQQQQQRPALKVREHPIF------GPYVV----DLSAHSVDSYSALRNWLAVGNSQRATASTAMN 361

  Fly   226 AQSSRSHTVFSIVVHI----RENGIEGED---------MLKIGKLNLVDLAGSENVSKAGNEKGI 277
            .:|||||::|:||:::    .::|:..:.         ..:..|::||||||||.:|.:|: .|.
  Fly   362 DKSSRSHSIFNIVLNLTDLSSDDGLSSDTDSSTASSLRQTRRSKISLVDLAGSERISVSGS-NGE 425

  Fly   278 RVRETVNINQSLLTLGRVITALVDR--------------APHVPYRESKLTRLLQESLGGRTKTS 328
            |:||.|:||:||||||:||.||.|.              :..||||||.||.||:|:|||.:||.
  Fly   426 RIREGVSINKSLLTLGKVIAALADSRKAIANGPLGSGTPSTFVPYRESVLTWLLRENLGGNSKTV 490

  Fly   329 IIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLK---RDLMAAR 390
            ::|||||.....:|||:||.||.:|::|.|:.:||:....| ::::...|:|:||   .:....|
  Fly   491 MLATISPASIHADETLATLRYACKARSIVNRVKVNESPHDK-IIRDLRAEVDRLKSLRNEYERQR 554

  Fly   391 DKNGIYLAEETYGEITLKLESQNRELNEKMLL--------LKALKDELQNKEKIFSEVSMSLVEK 447
            ..:|                :.|..:..|:::        ::||:.:|..:|:..|....|.:||
  Fly   555 RLSG----------------NSNNPVPRKIIIETSVDETEVEALRQQLAERERELSRAQKSWMEK 603

  Fly   448 TQEL---KKTEENLLNTKGTLL-LTKKVLTKTKRRYKEKKELVASHMKTEQVLTTQAQEIL---- 504
            .:|.   :|:|..:|..:|..| ||           .|:|:....::..:.:|:.....:|
  Fly   604 LKEAEDQRKSELRVLKRRGLALELT-----------AEQKQACLVNLTADPILSGTLFYLLPQGL 657

  Fly   505 --------------AAADLATDD--THQLHGTIERRRELDEKIRRSCDQFKDRMQDNLEMIGGSL 553
                          :..|:..|.  ....|.:||..|                 ...|.:|.||
  Fly   658 VRIGRGRLPGGSSSSQPDIVLDGPLVALQHCSIEHER-----------------GGKLYVIPGS- 704

  Fly   554 NLYQDQQAALKEQLSQEMVNSSYVSQRLALNSSKSIEMLKEMCAQSLQDQTNLHNKLIGEVMKIS 618
               :|.:..:..:|.::. ...:...||.:..|....:....|:|.            |:.
  Fly   705 ---EDFETYVNGELLKDR-RQLFHGDRLVIGGSHYFRISNPFCSQR------------GKA---- 749

  Fly   619 DQHSQAFVAKLMEQMQQQQLLMSKEIQTNLQVIEENNQRHKAMLDSMQEKFATIIDSSLQSVEEH 683
             .|...|      |:..|::|..:|.|...::..|.    :|.|..::::.|           :|
  Fly   750 -DHPVDF------QLAHQEILQKQEQQLRSELEAEK----RAALTKIEQERA-----------QH 792

  Fly   684 AKQMHKKLEQLGAMSLPDAEELQNLQ-----EELANER---ALAQQEDALLESMMMQMEQIKNLR 740
            |:...::|:.|         ||:..:     |.|..||   |||||::   .:.:...:.:....
  Fly   793 ARDFEERLQCL---------ELEQFKYKCNSEMLETERQALALAQQQE---HTPLRHEDAVSTPA 845

  Fly   741 SKNSISMSVH---LNKMEESRLTRNHRID-DIKSGIQDYQKLG--IEASQSAQAELTSQMEAGML 799
            .|::|...:.   ||..|||.    |:.. .:|...|..::|.  :|..|:...:....:...:|
  Fly   846 QKSTILEDIQRIMLNPSEESL----HKTQLMVKEATQRCRQLDLPLEFRQTQTPDEFGLLRTVIL 906

  Fly   800 CLDQ-------------GVANCSMLQVHMKNLNQKYEKETNENVGSVRVHHNQVEIICQESKQQL 851
            .||:             ||    .|.:...|..|:.:........||.|....::....|:....
  Fly   907 ILDKQRGLKAEWPTARLGV----WLDLVRDNAEQQEKLNATTIFQSVEVDWEPLDADLNETLSDT 967

  Fly   852 EAVQEKTEVNLEQMVDARQQLITEDRQRFIGHATVATDLVQESNRQFSEHAEHQRQQLQICEQEL 916
            .. ..:..:||..|.|.   |:.:..:|.:.    |:.....:.||.|..:.         ..:|
  Fly   968 HN-SSRIALNLSAMKDV---LLNKPLKRLLN----ASSSKSNTPRQTSTPSP---------GSQL 1015

  Fly   917 VRFQQSELKTYAPTGTTPSKRDFVYPRTLVATSPHQEI------VRRYRQELDWSDLDTTATIDE 975
            |.|.: .|.||.|.....|:..|.   |||    .||:      .:|.|:..:      .|.::.
  Fly  1016 VHFTK-RLLTYDPEEIPESQSSFT---TLV----QQELQIMQRSAQRLRRHCE------AALLER 1066

  Fly   976 CSEGEHDVSMHSVQE-LSETETIMN 999
            .:..::.|...|:|| |:..:|::|
  Fly  1067 ENHQDNGVLAVSLQEALARMDTVLN 1091

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	153/425 (36%)
		Kinesin	25..356	CDD:278646	146/410 (36%)
		Microtub_bind	923..>1009	CDD:290642	21/84 (25%)
neb	NP_476817.1	KISc_KIF1A_KIF1B	119..525	CDD:276816	151/423 (36%)
		KISc	120..525	CDD:214526	151/423 (36%)
		Kinesin_assoc	524..657	CDD:292801	31/160 (19%)
		FHA	634..740	CDD:238017	17/127 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437914
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930