DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp61F and nod

DIOPT Version :9

Sequence 1:	NP_476818.1	Gene:	Klp61F / 38135	FlyBaseID:	FBgn0004378	Length:	1066	Species:	Drosophila melanogaster
Sequence 2:	NP_001285129.1	Gene:	nod / 32107	FlyBaseID:	FBgn0002948	Length:	666	Species:	Drosophila melanogaster

Alignment Length:	740	Identity:	174/740 - (23%)
Similarity:	300/740 - (40%)	Gaps:	172/740 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 KFTFDRSFGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWED 127
            :|.||.:|.....|.::|..::.||::::|.|:.||..|||||||||:::|......|:.
  Fly    47 EFHFDHAFPATISQDEMYQALILPLVDKLLEGFQCTALAYGQTGTGKSYSMGMTPPGEIL----- 106

  Fly   128 DSDIGIIPRALSHLFDELRMMEVEYTMRI----SYLELYNEELCDLLSTDDTTKIRIFDDSTKKG 188
            ...:||:||||..:|:.:...:......|    |::|:|||:..|||.            ||...
  Fly   107 PEHLGILPRALGDIFERVTARQENNKDAIQVYASFIEIYNEKPFDLLG------------STPHM 159

  Fly   189 SVIIQGLEE---IPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGED 250
            .::....:.   :|:||:.|::.:||.|...|:...|.||:.|||||.:  :.:|::..
  Fly   160 PMVAARCQRCTCLPLHSQADLHHILELGTRNRRVRPTNMNSNSSRSHAI--VTIHVKSK------ 216

  Fly   251 MLKIGKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVDRAPHVPYRESKLTR 315
             ....::|:|||||||.|.:.|:| |:..:|.||||..||::.:|:.::......:|||:|.||.
  Fly   217 -THHSRMNIVDLAGSEGVRRTGHE-GVARQEGVNINLGLLSINKVVMSMAAGHTVIPYRDSVLTT 279

  Fly   316 LLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEID 380
            :||.||..::..:.:|.|||...|:.||||||.:...||.::..|
  Fly   280 VLQASLTAQSYLTFLACISPHQCDLSETLSTLRFGTSAKKLRLNP-------------------- 324

  Fly   381 KLKRDLMAARDKNGIYLAEETYGEITLKLESQNRELNEKMLLLKALKDELQNKEKIFSEVSMSLV 445
                 :..||.|..  ||..|           .....:.:....|:|....|...|.  |..|..
  Fly   325 -----MQVARQKQS--LAART-----------THVFRQALCTSTAIKSNAANHNSIV--VPKSKY 369

  Fly   446 EKTQELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEKKELVASHMKTEQV-LTTQAQEILAAADL 509
            ..|:.|...   |..|:..|.:|    .|.|:|.:|..||..:.::...: :...:..:|.
  Fly   370 STTKPLSAV---LHRTRSELGMT----PKAKKRARELLELEETTLELSSIHIQDSSLSLLG---- 423

  Fly   510 ATDDTHQLHGTIERRREL-----DEKIRRSCDQFKDRMQDNLEMIGGSLNLYQDQQAALKEQLSQ 569
                   .|...::.|.|     .::.|::..|       |..::|    :.::.:.....::.|
  Fly   424 -------FHSDSDKDRHLMPPPTGQEPRQASSQ-------NSTLMG----IVEETEPKESSKVQQ 470

  Fly   570 EMV-------------NSSYVSQRLALNSSK----SIEMLKEMCAQSLQDQTNLHNKLIGEVMKI 617
            .||             |::.....|..:||:    .|:.::|....|.|...     |...|...
  Fly   471 SMVAPTVPTTVRCQLFNTTISPISLRASSSQRELSGIQPMEETVVASPQQPC-----LRRSVRLA 530

  Fly   618 SDQHSQAF--VAKLMEQMQQQQLLMSKEIQTNLQVIEENNQRHKAMLDSMQEKFATIIDSSLQSV 680
            |...||.:  :.|:|                        |.|....|..::|...:::..:....
  Fly   531 SSMRSQNYGAIPKVM------------------------NLRRSTRLAGIREHATSVVVKNETDA 571

  Fly   681 EEHAKQMHKKLEQLGAMSLPDAEELQNLQEELANERALAQQEDALLESMMMQMEQIKNLRSKNSI 745
            ..|.:...:|.........|.|....|.:..|          |.|....:.|:::|..:..|::.
  Fly   572 IPHLRSTVQKKRTRNVKPAPKAWMANNTKCFL----------DLLNNGNVKQLQEIPGIGPKSAF 626

  Fly   746 SMSVHLNKMEESRLTRNHRIDDIKS 770
            |:::|     .|||.....:..:||
  Fly   627 SLALH-----RSRLGCFENLFQVKS 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	102/308 (33%)
		Kinesin	25..356	CDD:278646	101/299 (34%)
		Microtub_bind	923..>1009	CDD:290642
nod	NP_001285129.1	KISc	8..325	CDD:214526	102/329 (31%)
		KISc	8..318	CDD:276812	99/297 (33%)
		ComEA	540..648	CDD:224472	24/146 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468181
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840