DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp61F and Klp10A

DIOPT Version :9

Sequence 1:	NP_476818.1	Gene:	Klp61F / 38135	FlyBaseID:	FBgn0004378	Length:	1066	Species:	Drosophila melanogaster
Sequence 2:	NP_001285109.1	Gene:	Klp10A / 32049	FlyBaseID:	FBgn0030268	Length:	805	Species:	Drosophila melanogaster

Alignment Length:	493	Identity:	156/493 - (31%)
Similarity:	241/493 - (48%)	Gaps:	52/493 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 QKKSNQNIQVYVRVRPLNSRERCIRSAEVVDVVGPR-EVVTRHTLDSK--LTK-----KFTFDRS 69
            |...:..|.|.||.||::.:|...:..:|:.|  || :::..|...||  |||     ||.||.:
  Fly   272 QAVDDHQITVCVRKRPISRKEVNRKEIDVISV--PRKDMLIVHEPRSKVDLTKFLENHKFRFDYA 334

  Fly    70 FGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGII 134
            |........||.....||::.:..|...|.|||||||:||||||.|....:::     |...||.
  Fly   335 FNDTCDNAMVYKYTAKPLVKTIFEGGMATCFAYGQTGSGKTHTMGGEFNGKVQ-----DCKNGIY 394

  Fly   135 PRALSHLFDELRM---MEVEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSVIIQGLE 196
            ..|...:|..|.|   ..:...:..|:.|:|:.::.||||  |..|:|:.:|.  |..|.:.||.
  Fly   395 AMAAKDVFVTLNMPRYRAMNLVVSASFFEIYSGKVFDLLS--DKQKLRVLEDG--KQQVQVVGLT 455

  Fly   197 EIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKI-GKLNLV 260
            |..|...::|.||::.|...|.:..|..|:.|||||.||.||  :|..|     ..|| ||.:.:
  Fly   456 EKVVDGVEEVLKLIQHGNAARTSGQTSANSNSSRSHAVFQIV--LRPQG-----STKIHGKFSFI 513

  Fly   261 DLAGSE-NVSKAGNEKGIRVRETVNINQSLLTLGRVITALVDRAPHVPYRESKLTRLLQES-LGG 323
            ||||:| .|..:..::..|: |...||:|||.|...|.||..::.|:|:|.||||::|::| :|.
  Fly   514 DLAGNERGVDTSSADRQTRM-EGAEINKSLLALKECIRALGKQSAHLPFRVSKLTQVLRDSFIGE 577

  Fly   324 RTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLKRDLM- 387
            ::||.:||.||||....|.||:||.||.|.|.:..|..|.......|...|.|::.::.:.:::
  Fly   578 KSKTCMIAMISPGLSSCEHTLNTLRYADRVKELVVKDIVEVCPGGDTEPIEITDDEEEEELNMVH 642

  Fly   388 -------------AARDKNGIYLAEETYGEITLKLESQNREL----NEKMLLLKALKDELQNKEK 435
                         |::..|....|....|.:.....:.|.:.    |..:.:|.:|.:...:.|.
  Fly   643 PHSHQLHPNSHAPASQSNNQRAPASHHSGAVIHNNNNNNNKNGNAGNMDLAMLSSLSEHEMSDEL 707

  Fly   436 IFSEVSMSLVEKTQELKKTEENLLN-TKGTLLLTKKVL 472
            |....::..:::|:|:.......:| |..|.|...|.|
  Fly   708 IVQHQAIDDLQQTEEMVVEYHRTVNATLETFLAESKAL 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	134/361 (37%)
		Kinesin	25..356	CDD:278646	129/344 (38%)
		Microtub_bind	923..>1009	CDD:290642
Klp10A	NP_001285109.1	KISc_KIF2_like	278..608	CDD:276818	131/348 (38%)
Klp10A	NP_001285109.1	Kinesin	284..609	CDD:278646	128/343 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45437800
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840