Protein Alignment Klp61F and Kif6

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: NP_796026.2
• Gene: Kif6 / 319991
• MGIID: 1098238
• Length: 802
• Species: Mus musculus
• Alignment Length: 910
• Identity: 232/910 - (25%)
• Similarity: 421/910 - (46%)
• Gaps: 173/910 - (19%)

  Fly    18 QNIQVYVRVRP-----------LNSRERCIRSAEVVDVVGPREVVTRHTLDSKLTKKFTFDRSFG 71
            |.||::.||:|           ::..|:...|.|   :|.||::......:.:.:.||.|.|.|.
Mouse     4 QTIQIFARVKPTVRKQQQGIYSIDEDEKLTHSLE---IVLPRDLADGFVNNKRESYKFKFQRIFD 65

  Fly    72 PESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGIIPR 136
            .|:||..::.::..|:.|..|.|||.|:|||||||:|||.|:.|..        |..||.|||||
Mouse    66 QEAKQEIIFEIIAKPVAESTLAGYNGTIFAYGQTGSGKTFTITGGA--------ERYSDRGIIPR 122

  Fly   137 ALSHLFDELRMMEVE-YTMRISYLELYNEELCDLL-------STDDTTKIRIFDDSTKKGSVIIQ 193
            .||::|::|:....: ||..|||||:|||...|||       ..:|..|:.|.:|..:  ::.::
Mouse   123 TLSYIFEQLQKDSSKIYTTHISYLEIYNECGYDLLDPRHEASKLEDLPKVTILEDPDQ--NIHLK 185

  Fly   194 GLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIGKLN 258
            .|......::::...||..|...|..|.|.||..|:|||.:|::.:..:|   .|...::..||:
Mouse   186 NLSLHQATTEEEALNLLFLGDTNRMIAETPMNQASTRSHCIFTVHLSSKE---PGSATVRHAKLH 247

  Fly   259 LVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVDR-APHVPYRESKLTRLLQESLG 322
            ||||||||.|||.| ..|:.:.|...||.||..|.:||.||.:: ..|:|||.|.:|.:|::|||
Mouse   248 LVDLAGSERVSKTG-VGGLLLTEAKYINLSLHYLEQVIIALSEKHRTHIPYRNSMMTSVLRDSLG 311

  Fly   323 GRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLKRDL- 386
            |...|::|||:|...::|:|::||..:|.|...|:|:..:|:::..:.::....:||:.||.:|
Mouse   312 GNCMTTMIATLSLEKRNIDESISTCRFAQRVALIKNEAILNEEIDPRLMIVRLQKEIEDLKAELA 376

  Fly   387 MAARDKNGIYLAEETYGEITLKLESQNRELNEKMLLLKALKDELQNKEKIFSEVSMSLVEKTQEL 451
            ||..::....|.|   .|: |:||.         |:...|:|  |:.|        |.:|...::
Mouse   377 MATGEQRTEALTE---AEL-LQLEK---------LIASYLED--QDPE--------SRLEVGADM 418

  Fly   452 KKTE------ENLLNTKGTLLLTKKVLTKTKRRYKEKKELVASHMKTEQVLTTQAQEILAAADLA 510
            :|..      :.|||.|.||                           |..:::::........|.
Mouse   419 RKIHHCFHHFKKLLNDKKTL---------------------------ENTVSSESTRQACQEPLR 456

  Fly   511 TDDTHQLHGTIERRRELDEKIR---RSCDQFKDRMQDNLEMIGGSLNLYQDQQAALKEQLSQEMV 572
            .::..:|.|.:::|   |.:|.   ....:.|.:.||.|            |.::|::..::...
Mouse   457 DEEYTKLLGLLKQR---DNEINILVNMLKKEKKKTQDAL------------QNSSLEKSDTRPPQ 506

  Fly   573 NSSYVS-----QRLALNSSKSIEMLKEMCAQSLQDQTNLHNKLIGEVMKISDQHSQAFVAKLMEQ 632
            ||.:::     .|...:|:.|......:|    :.:::|.:|..|...::|....:||      :
Mouse   507 NSPFIAGSPAVPRTPFSSAPSHTQDLSIC----RHRSSLLHKKTGMREEMSLGRQEAF------E 561

  Fly   633 MQQQQLLMSKEIQTNLQVIEENNQRHKAMLDSMQEKFATIIDSSLQSVEEHAKQMHKKLEQLG-- 695
            :.::....|..|:.|.||:::.....||:.:|:.|     ..|.:..:::...|.|.:...||
Mouse   562 IFKRDHADSVTIEDNKQVLKQRFSEAKALGESINE-----ARSKIGQLKDAINQRHLQQVALGIS 621

  Fly   696 ----AMSLPDAEELQNLQEELANERALAQQEDALLESMMMQMEQIKNLRSKNSISMSVHLNKM-- 754
                ..|.||.:| :.|:.:|..|:...:.....|:::.:::|.::.|..|..:.:.......
Mouse   622 ENTVPASTPDPQE-EKLRAQLEEEKGRYKTAFMHLKALKVEIEHLQLLMDKAKVKLQKEFEAWWA 685

  Fly   755 -EESRLTRNHRIDDIKSGIQDYQKLGIEASQSAQAELTSQMEAGMLCLDQGVANCSMLQVHMKNL 818
             |.:.|..|....:::..::.:       .|..||:|.|:..:..|.::.|.....:...:.:.:
Mouse   686 EEATSLQVNSPATNLQDAVKPF-------PQQDQAQLLSKKSSRDLEVENGAGRLEVCDRNARRI 743

  Fly   819 ------NQKYEKETNENVGSVRVHHNQVEIICQESKQQLEAV----QEKTEVNLEQMVDARQQLI 873
                  ||    ::.|..||        .::.|:  :.|.::    ..:|:.::...:.|||.::
Mouse   744 LPSPCPNQ----QSQEPSGS--------RVLVQD--RPLSSIPLTGDSQTDSDILAFIKARQSIL 794

  Fly   874  873
            Mouse   795  794

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	134/366 (37%)
		SMC_prok_B	<408..728	CDD:274008	63/339 (19%)
		SMC_prok_B	<651..>921	CDD:274008	41/242 (17%)
		Microtub_bind	923..>1004	CDD:464048
Kif6	NP_796026.2	KISc_KIF9_like	5..343	CDD:276826	130/354 (37%)
		GumC	<557..>726	CDD:442439	36/187 (19%)