Protein Alignment Klp61F and Kif12

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: XP_006238315.1
• Gene: Kif12 / 313254
• RGDID: 1308487
• Length: 648
• Species: Rattus norvegicus
• Alignment Length: 496
• Identity: 151/496 - (30%)
• Similarity: 240/496 - (48%)
• Gaps: 98/496 - (19%)

  Fly     6 GNTSR---QPQKKSNQNIQVYVRVRPLNSRE---------RC--IRSAEVVDVVGPREVVTRH-- 54
            |:.:|   |..:.|...|||.:||||:::.|         .|  .|:.:|....|..:|..|.
  Rat     9 GDPARNLEQGPEGSETPIQVVLRVRPMSTVELRRGEQSALHCSGTRTLQVSPPGGGPDVAFRFGA 73

  Fly    55 TLDSKLTKKFTFDRSFGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETA 119
            .||...|::..| |:.|            |..|.|..|.|::||||.:||||:|||:|:.| ...
  Rat    74 VLDGARTQEDVF-RACG------------VKRLGELALRGFSCTVFTFGQTGSGKTYTLTG-PPP 124

  Fly   120 ELKSSWEDDSDIGIIPRALSHLFDELRMMEVEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDS 184
            :.:......|..||:.|..:.|.|.::.::...|:|.||||:|||::.||||......:.:  ..
  Rat   125 QAEGVPVPPSLAGIMQRTFTWLLDRMQHLDSPVTLRASYLEIYNEQVQDLLSQGSPRPLPV--RW 187

  Fly   185 TKKGSVIIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIE-- 247
            :|.....::.|..:...|.:.:.:||:.|..||::::..:|..|||||.:  :.:||.....:
  Rat   188 SKARGFYVEQLRLVECGSLEALMELLQMGLSRRRSSSHTLNQASSRSHAL--LTLHISRPTSQQV 250

  Fly   248 -----GEDMLKIGKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVD---RAP 304
                 ||..:. |||..|||||||.|:..|: :|..:.|..:||:|||.||..|:.|:|   :..
  Rat   251 PPVDLGEPPVG-GKLCFVDLAGSEKVAATGS-RGQLMLEANSINRSLLALGHCISLLLDPQRKQS 313

  Fly   305 HVPYRESKLTRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKP--------- 360
            |:|:|:||||:||.:|||||..|.::|.:||..:.:.||||||.||.||:.|..:|
  Rat   314 HIPFRDSKLTKLLADSLGGRGVTLMVACVSPSAQCLPETLSTLRYASRAQRITTRPQGPKSPAVK 378

  Fly   361 ---------------------EVNQKLTKKT----------------VLKEYTEEIDKLKRDLMA 388
                                 :::|..||..                :|:|:..|.:||::::..
  Rat   379 PPQQVEAELLQLQEENRCLRLQLDQMYTKAPRVHGARVAWAQRNLYGMLQEFMLENEKLRKEMRQ 443

  Fly   389 ARDKNGIYLAEETYGEITLKLESQNRELNEKMLLLKALKDE 429
            .|....:..||:..      |..|..||..::||..:|..:
  Rat   444 LRSSRDLAQAEQHV------LAQQIHELERRLLLACSLPQQ 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	129/400 (32%)
		SMC_prok_B	<408..728	CDD:274008	7/22 (32%)
		SMC_prok_B	<651..>921	CDD:274008
		Microtub_bind	923..>1004	CDD:464048
Kif12	XP_006238315.1	KISc	25..363	CDD:276812	126/357 (35%)