Protein Alignment Klp61F and Kif19

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: NP_001402044.1
• Gene: Kif19 / 303659
• RGDID: 1559936
• Length: 997
• Species: Rattus norvegicus
• Alignment Length: 1159
• Identity: 270/1159 - (23%)
• Similarity: 467/1159 - (40%)
• Gaps: 284/1159 - (24%)

  Fly    17 NQNIQVYVRVRPLN---SRERCIRSAEVVD---------VVGPREVVTRHTLDSKLTKKFTFDRS 69
            :|.:.|.:||||::   ..|.....|..||         :..|.:::..|   ....|.:.||.:
  Rat     9 DQQLMVALRVRPISVSELEEGATLIAHKVDEQMVVLMDPMEDPDDILRAH---RSREKSYLFDVA 70

  Fly    70 FGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGII 134
            |...:.|..||......|||.|::|||.||||||.||.|||:||:|.           |.:.||.
  Rat    71 FDFTATQEMVYQATTKSLIEGVISGYNATVFAYGPTGCGKTYTMLGT-----------DHEPGIY 124

  Fly   135 PRALSHLFD--ELRMMEVEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSVIIQGLEE 197
            .|.|:.||.  |....::||.:.:||||:|||.:.|||: .....:.:.:||  ||.:.:.|:.|
  Rat   125 VRTLNDLFRAIEETSNDMEYEVSMSYLEIYNEMIRDLLN-PALGYLELREDS--KGVIQVAGITE 186

  Fly   198 IPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIGKLNLVDL 262
            :...:..::.:||.||..:|....|..|..|||||.|..:.|..|.........::.|:|.::||
  Rat   187 VSTINAKEIMQLLMKGNRQRTQEPTAANQTSSRSHAVLQVAVRQRNRVKNILQEVRQGRLFMIDL 251

  Fly   263 AGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVDRA--PHVPYRESKLTRLLQESLGGRT 325
            ||||..|:..| :|.|::|..:||:|||.||..|.||.|:.  .::.||:|||||||::||||.:
  Rat   252 AGSERASQTQN-RGQRMKEGAHINRSLLALGNCINALSDKGGNKYINYRDSKLTRLLKDSLGGNS 315

  Fly   326 KTSIIATISPGHKDIEETLSTLEYAHRAKNI-----QNKPEVNQKLTKKT-VLKEYTEEIDKL-- 382
            :|.:||.|||.....||:.:||.||.|||||     ||...|:..:.:.| ::.:...||.:|
  Rat   316 RTVMIAHISPASTAFEESRNTLTYAGRAKNIRTRVKQNLLNVSYHIAQYTSIIADLRGEIQRLKC 380

  Fly   383 KRDLMAAR-------DKNGIYLAEETYGEITL----KLESQNRELNEKMLLLKALKDELQNKEKI 436
            |.|..|.|       |:..|   .....|:.|    :.:::..:|.|:  |:.|..:::..:.::
  Rat   381 KIDQQAGRGQARGKLDRGDI---RHIQAEVQLHSGQEEQAEMGQLREQ--LISAFHEQMDVRRRL 440

  Fly   437 FSEVSMSLVEKTQELK-KTEENLLNTKGTLLLTKKVLTKTKRRYKEKKELVAS--HMKTEQVLTT 498
                 :.|..:..|:: .|..:||.                         :||  |.|:.:.|..
  Rat   441 -----LELENQAMEVQIDTSRHLLT-------------------------IASWEHEKSRRALKW 475

  Fly   499 QAQEILAAADLATDDTHQLHGTIERRRELDEKIRRSCDQFKDRMQDNLE-------------MIG 550
            :.                     |||:|...|.....|.......||||             ::|
  Rat   476 RE---------------------ERRKESYTKEDSEKDSDTGDEPDNLEPPEVASARENIAALVG 519

  Fly   551 GSLNLYQDQQAALKEQLSQEMVNSSYVSQRL--ALNSSKSIEMLKEMCAQSLQDQTNLHNKLIGE 613
            ....| :.::.||:::..:.......:.:.|  .:.|.:..|:|..:|                .
  Rat   520 EQKKL-RKEKLALEQRCRELRARGRRLEETLPRRIGSEEQREVLSLLC----------------R 567

  Fly   614 VMKISDQHSQAFVAKLMEQMQQQQLLMSKEIQTNLQVIEENNQRHKAMLDSMQEKFATIIDSSLQ 678
            |.::..:::         :||...||....::...:.:....| |:::.|.       ||....|
  Rat   568 VHELEVENT---------EMQSHALLRDSALRHRREAVRRLEQ-HRSLCDE-------IIQGQRQ 615

  Fly   679 SVEEHAKQMHKKLEQLGAMSLPDAEELQNLQEELANERALAQQEDALLESMM------------- 730
            .::::..::.:.||:|..:.|.:.|| .:|:.....:|..::   ||.:|.:
  Rat   616 IIDDYNLEIPRHLEELYEVYLRELEE-GSLERATIMDRVASR---ALQDSSLPKITPAGTTLTPD 676

  Fly   731 MQMEQIKNLRSKNSISMSVHLNKMEESRLTRNHRIDDIKSGIQDYQKLGIEAS------QSAQAE 789
            ..:|.:|.|.|              |::..:|:.:..:.:....|..  .:||      :|:...
  Rat   677 SDLESVKTLSS--------------EAQCPQNNTLPPLGTDSDSYHM--FKASPRAWQVKSSSVP 725

  Fly   790 LTSQMEAGMLCLDQGVANCSMLQVHMKNLNQKYEKETNENVGSVRVHHNQ-VEIICQESKQQLEA 853
            ....::.|.|...:.....|:    ...:|.  ..:::||:..:.:.|.: .||:.:.....::|
  Rat   726 TPPPIQVGSLVTQEAPPQDSL----GSQINS--SPDSSENLSEILLSHKERKEILTRTKCISVKA 784

  Fly   854 VQEKTEVNLEQMVDARQQLITEDRQRFIGHATVATDLVQESNRQFSEHAEHQRQQLQICEQ---E 915
            .|.::           :.|.||.| ..:..||..:.|   |....||..:.:......|::   .
  Rat   785 AQRRS-----------RALGTEGR-HLLAPATERSSL---SLHSLSEADDVRPPGPLACKRPPSP 834

  Fly   916 LVRFQQSELKTYAPTGTTPSKRDFVYPR-----------TLVATSPHQEIVRRYRQELDWSDLDT 969
            .::...||....:.||..|::.  |.||           ....:...:|.:...|::......:.
  Rat   835 TLQHAISEDNLSSSTGEGPARA--VGPRGDGSGPWVRGQKKCLSKKREESLEAKRRKRRSRSFEV 897

  Fly   970 TATIDECSEGEHDVSMHSVQELSETETIMNSTPIEPVDGVTVKR--GCGTTR------------- 1019
            |.                 |.||.::|.:...  .|.:||:.:|  .||...
  Rat   898 TG-----------------QGLSRSKTHLLGP--RPSEGVSDRRMPACGRPSPGVRHLGKVSLPL 943

  Fly  1020 -------NSNSNALKPPVATGGKRSSSLSRSLTPSKTSPRGSPAF-----VRHN 1061
                   |.|:.:..|.........:.:||..|.....|.||..|     ::||
  Rat   944 AKVKFPPNQNTGSGNPSPLLVPSNQAGVSRRATRGPNLPHGSSTFGKDGRLQHN 997

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	138/368 (38%)
		SMC_prok_B	<408..728	CDD:274008	54/337 (16%)
		SMC_prok_B	<651..>921	CDD:274008	49/292 (17%)
		Microtub_bind	923..>1004	CDD:464048	14/91 (15%)
Kif19	NP_001402044.1	KISc_KIP3_like	11..346	CDD:276821	132/352 (38%)
		Smc	<340..>605	CDD:440809	61/347 (18%)