Protein Alignment Klp61F and Kif18b

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: NP_001427099.1
• Gene: Kif18b / 303575
• RGDID: 1310360
• Length: 841
• Species: Rattus norvegicus
• Alignment Length: 827
• Identity: 214/827 - (25%)
• Similarity: 332/827 - (40%)
• Gaps: 208/827 - (25%)

  Fly    20 IQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHTLD-----------------SKLTKK---- 63
            ::|.|||||...:|...:...|:.||..|.:|    .|                 |...||
  Rat    10 VRVVVRVRPPTPKELESQRRPVIQVVDERMLV----FDPEECDGGFPGLKWSGSLSGPKKKGKDL 70

  Fly    64 -FTFDRSFGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWED 127
             |.|||.|...:.|.||:......:::..|.||||:|||||.||.||||||:|.|
  Rat    71 TFVFDRVFSEVATQQDVFQHTTHNILDSFLQGYNCSVFAYGATGAGKTHTMLGRE---------- 125

  Fly   128 DSDIGIIPRALSHLFDELR--MMEVEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSV 190
             .|.||:......|:..|.  ..|.::.:.|||||:|||::.|||.......||  :|..|  .|
  Rat   126 -GDPGIMYLTTMELYRRLEACQEEKQFEVLISYLEVYNEQIYDLLEPKGPLTIR--EDPDK--GV 185

  Fly   191 IIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEG-EDMLKI 254
            ::.||......|...:.::|.:|...|....|..||.|||||.:|.|.|. :::.:.| ...|::
  Rat   186 VVPGLSFHQPASAQQLLEMLTRGNCSRTQHPTDANATSSRSHAIFQIFVK-QQDRVPGLTQALRV 249

  Fly   255 GKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVD---RAPHVPYRESKLTRL 316
            .|::|:||||||..|.. :.||.|:||..|||:|||.|..|:.||.|   |..|||||:||||||
  Rat   250 AKMSLIDLAGSERASST-HAKGERLREGANINRSLLALINVLNALADAKGRKSHVPYRDSKLTRL 313

  Fly   317 LQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDK 381
            |::|:||..:|.:||.:||.....|:|.:||:||.|||.|        :||.|:.:......|.:
  Rat   314 LKDSIGGNCRTVMIAAVSPSSLTYEDTYNTLKYADRAKEI--------RLTLKSNVISLDHHISQ 370

  Fly   382 LKRDLMAARDKNGIYLAEETYGEITLKLESQNRELNEKMLLLKALKDELQNKEKIFSEVSMSLVE 446
                                |..|..:|:::...|.||:...:|....||.:.....::|:
  Rat   371 --------------------YATICQQLQAEVAALREKLQTYEAGAQALQQRSPQPPKLSI---- 411

  Fly   447 KTQELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEKKELVASHMKTEQVLTTQAQEILAAAD--- 508
                                               .:.|.:|.::......:.|.|..|..|
  Rat   412 -----------------------------------PQNLSSSPLQPGHSSQSCAPEFHAKYDAPQ 441

  Fly   509 ---LATDDTHQLHGTIERRRELDEKIRRSCDQFKDRMQDNLEMIGGSLNLYQDQQAALKEQLSQE 570
               |.||...|  ||:|.                              |..:.:|....:|...:
  Rat   442 EESLGTDSQGQ--GTVEE------------------------------NAPEQEQPPQDKQFPTQ 474

  Fly   571 MVNSSYVSQRLALNSSKSIEMLKEMCAQSLQDQTNLHNKLIGEVMKISDQHSQAFVAKLMEQMQQ 635
            |...:     |..:...:::..:.|...|||              ::..:||:....:::...|:
  Rat   475 MPEPN-----LPGSPCPTVQAKQGMNQHSLQ--------------RLDAEHSKQLALRVLRLAQR 520

  Fly   636 QQLLMSKEIQTNLQVIEENNQRHKAMLDSMQEKFATIIDSSLQSVEEHAKQMHKKLEQLGAMSLP 700
            |..|:               |....:...|..:|.|:....|:...||..:..:....  |..:|
  Rat   521 QYSLL---------------QAANLLTPDMISEFETLQQLVLEESMEHGAESPRSPGL--ARGIP 568

  Fly   701 DAEELQNLQEE----LANERALAQQEDALLESMMMQM-EQIKNLRSKNSISMSVHLNKMEESRLT 760
            .|:||.:...|    |:...|.:|:.......:...| :|:..|.....|.::......:.|:
  Rat   569 LAQELCSESSECPLSLSLRPACSQESSRYCGPVTRTMAKQLSGLTHTLGIPLAPDCTSDKTSQ-- 631

  Fly   761 RNHRIDDIKSGIQDYQKLGIEASQSAQA---ELTSQMEAGMLCLDQG 804
                    |...:..:||.:|...|..|   |:..|.::.:.||.:|
  Rat   632 --------KPTKEKKRKLNLEEPGSLPAPSVEMKRQRQSFLPCLRRG 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	141/372 (38%)
		SMC_prok_B	<408..728	CDD:274008	51/329 (16%)
		SMC_prok_B	<651..>921	CDD:274008	32/162 (20%)
		Microtub_bind	923..>1004	CDD:464048
Kif18b	NP_001427099.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	396..496		22/175 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	617..700		13/64 (20%)
		Nuclear localization signal. /evidence=ECO:0000250	633..641		0/7 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	777..803