Protein Alignment Klp61F and Kif7

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: NP_001419074.1
• Gene: Kif7 / 293047
• RGDID: 1310310
• Length: 1341
• Species: Rattus norvegicus
• Alignment Length: 1253
• Identity: 308/1253 - (24%)
• Similarity: 483/1253 - (38%)
• Gaps: 372/1253 - (29%)

  Fly    11 QPQKKSNQN---IQVYVRVRPLNSRERCIRSAEVVDVVGPREVVT----RHTLDSKLTKKFTFDR 68
            :.||.|...   ::|.:|||||..:|........:.|...|..:|    ||         |.|..
  Rat     4 EAQKLSGAEEAPVRVALRVRPLLPKELLHGHQSCLQVEPERGRITLGRDRH---------FGFHV 59

  Fly    69 SFGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGI 133
            ..|.::.|..||...|.||:|....|:|.|||||||||:|||:||   ..|.:.|..||:.  ||
  Rat    60 VLGEDAGQEAVYQACVQPLLEAFFEGFNATVFAYGQTGSGKTYTM---GEASVASLHEDEQ--GI 119

  Fly   134 IPRALSHLF---DELRMMEVEYTMRISYLELYNEELCDLLSTDDTTK-IRIFDDSTKKGSVIIQG 194
            ||||::..|   ||..:::.  .:.:||||||.||..|||.....:: |::.:|.  :|:|::.|
  Rat   120 IPRAMAEAFKLIDENDLLDC--LVHVSYLELYKEEFRDLLEVGTASRDIQLREDD--RGNVVLCG 180

  Fly   195 LEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENG-----IEGEDMLKI 254
            ::|:.|...|:|..|||.|...|.|..|..|..||||||||::.:..|...     ..|...|.:
  Rat   181 VKEVDVEGLDEVLSLLEMGNAARHTGATHFNRLSSRSHTVFTVTLEQRGRAPTRLPRPGAGHLLV 245

  Fly   255 GKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVD---RAPHVPYRESKLTRL 316
            .|.:.|||||||.|.|.|: .|.|::|::.||.:||.||.||:||.|   |..|:|||:||:||:
  Rat   246 SKFHFVDLAGSERVLKTGS-TGERLKESIQINSTLLALGNVISALGDPQRRGSHIPYRDSKITRI 309

  Fly   317 LQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEY------ 375
            |::||||..||.:||.:||...|.:|||:||.||.||:||:|:..||.:...:.|.:|.
  Rat   310 LKDSLGGNAKTVMIACVSPSSSDFDETLNTLNYASRAQNIRNRATVNWRPEAERVPEEQAAGARG 374

  Fly   376 -----------------------------------------TEEIDKLKRDLMA----------- 388
                                                     |.....|.|:|.|
  Rat   375 PPRHRSETRIIHRGRRVLCPGVGSAAVAPGLGTECARCRARTSAAYSLLRELQAEPGLPGAAARK 439

  Fly   389 ARD------------------KNGI-------YLAEETYG--------------EITLKLESQNR 414
            .||                  .:||       ..|:.|.|              ....:||.:||
  Rat   440 VRDWLCAVEGERSALSSASGPDSGIESAPADDQAAQGTSGRKGDEGAQQLLILQSQVARLEEENR 504

  Fly   415 E----LNEKMLLLKALKDELQNKEKIFSEVSM---------------------SLVEK--TQELK 452
            :    |.:.|...|...|.|:.:::...|:.:                     |.|.:  |..|.
  Rat   505 DFLAALEDAMEQYKLQSDRLREQQEEMVELRLRLELAQPGWGAPGLLQGLSPGSFVPRPHTAPLG 569

  Fly   453 KTEENLLNTKGTLLLTKKVLTKTKRRYKEKKELVASHMKTEQVLTTQAQEILAAADLATDDTHQ- 516
            ....::..|.....|..:.::        .::.||:..:.:..|..|..::.:|:...:::..:
  Rat   570 GAHTHMTGTMPRTCLPGEEVS--------SEQQVANGKEAKAELLAQVDKLGSASSTTSEEEEEE 626

  Fly   517 ----LHGTIERRRE----------------LDEKIRRSCDQFKDRMQDNLEMIGGSLNLYQDQQA 561
                ...|:..||.                .|.|....|.:.........:.:|||....|.:||
  Rat   627 EEEPPRRTLHLRRNGISNWSQRAGVRPGSPPDRKGPEVCPEEPAAAIPAPQAVGGSKAPGQTRQA 691

  Fly   562 ------------------------ALKEQLSQEMVNSSYVSQRLALNSSKSIEMLK--------E 594
                                    .:||:|..|:|.:...:|.|....|:.|..|:        |
  Rat   692 PAAMASEWRLAQAQQKIRELAINIRMKEELIGELVRTGKAAQALNRQHSQRIRELEQEAERVRGE 756

  Fly   595 MC--------AQSLQDQTNLHNKLIGEVMK-ISDQHSQAFVAKLMEQMQQQQLLMSKEIQTNLQV 650
            :|        .:..:.|.......:.|..| ::...||..|.:..:|..::.:.:|.:.:|.||.
  Rat   757 LCEGQRQLRELEGREPQDASERSRLQEFRKRVAAAQSQVQVLREKKQATERLVSLSAQSETRLQE 821

  Fly   651 IEENNQ------------------------------RHKA----MLDSMQEKFATIIDSSL---- 677
            :|.|.|                              :|:.    :....|:|...|....:
  Rat   822 LERNVQLMRRQQGQLQRRLREETEQKRRLETEMNKRQHRVKELELKHEQQQKILKIKTEEIAAFQ 886

  Fly   678 -----------------QSVEEHAK----------QMHKKLEQLGAMSLPDAEELQNLQEELANE 715
                             |.:||..|          |..:.||:||       |||:..:..||.:
  Rat   887 RNRRSGSNGSVVSLEQQQKIEEQKKWLDQEMEKVLQQRRALEELG-------EELRKREVILAKK 944

  Fly   716 RALAQQEDALLESMMMQMEQIKNLRSKNSISMSVHLNKMEE------------SRLTRNH---RI 765
            .||.|::.. |||..|:..|..|   ::.:.:|..|..:|:            |.|.:..   .|
  Rat   945 EALMQEKTG-LESKRMRSSQALN---EDIVRVSSRLEHLEKELSEKSGQLRQGSALNQQQIRGEI 1005

  Fly   766 DDIKSGIQDY--QKLGIEASQSAQAELTSQMEAGMLCLDQGV----------------------A 806
            |.::......  |:|.|::.....:.|:.:.|..:..||:.:                      |
  Rat  1006 DTLRQEKDSLLKQRLEIDSKLRQGSLLSPEEERTLFQLDEAIEALDAAIEYKNEAITCRQRVLRA 1070

  Fly   807 NCSMLQVHMKNLNQKY----EKETN-------ENVGSVRVHHNQVEIICQESKQQLEAVQEKT-- 858
            :.|:|.....||..|.    ..||.       :.|.::|...:|.:|...|.:.|||..|...
  Rat  1071 SASLLSQCEMNLMAKLSYLSSSETRALLCKYFDKVVTLREEQHQQQIAFSELEMQLEEQQRLVYW 1135

  Fly   859 -EVNLE-QMVDARQQLITEDRQRFIGHATVATDLVQESNRQFSEH-AEHQRQ---QLQICEQELV 917
             ||.|| |.::..:||..:.::    |......|:|:......|. |:.:||   ::|..|:||.
  Rat  1136 LEVALERQRLEMDRQLTLQQKE----HEQNVQLLLQQGRDHLGEGLADSKRQYEARIQALEKELG 1196

  Fly   918 RFQ--QSELKTYAPTGTT 933
            |..  ..|||.....|.|
  Rat  1197 RHMWINQELKQKLSAGNT 1214

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	150/366 (41%)
		SMC_prok_B	<408..728	CDD:274008	81/473 (17%)
		SMC_prok_B	<651..>921	CDD:274008	80/394 (20%)
		Microtub_bind	923..>1004	CDD:464048	5/11 (45%)
Kif7	NP_001419074.1	KISc_KIF4	15..350	CDD:276823	146/353 (41%)
		Smc	<700..>1196	CDD:440809	101/510 (20%)