Protein Alignment Klp61F and klp3

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: NP_594686.1
• Gene: klp3 / 2542195
• PomBaseID: SPAC1834.07
• Length: 554
• Species: Schizosaccharomyces pombe
• Alignment Length: 595
• Identity: 193/595 - (32%)
• Similarity: 310/595 - (52%)
• Gaps: 79/595 - (13%)

  Fly    19 NIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHTLDSKLTKKFTFDRSFGPESKQCDVYSVV 83
            :|:|..|:||.|..|:.:...   :|:.|....|.|...|..:..|.|||.|.|.|.|.|::|..
pombe     3 SIKVVCRIRPTNQLEQDLGGN---NVIYPLNDSTVHIETSDYSGNFVFDRVFHPSSTQNDIFSYS 64

  Fly    84 VSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGIIPRALSHLFDELR-- 146
            :...::::..|||.||.||||||:|||:||:|     :::::|.:   |:.||.|..:||::|
pombe    65 IESTVDDLFLGYNGTVLAYGQTGSGKTYTMMG-----IENNFEKE---GMTPRMLRRIFDKIRDS 121

  Fly   147 MMEVEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSVIIQGLEEIPVHSKDDVYKLLE 211
            ....||.:::||:|:|.|::.|||| :...::.:.:|  |...|.:|||:.|.|.|:.:...:|.
pombe   122 PSTTEYEVKVSYMEIYMEKIHDLLS-EKNDRLTVHED--KLQGVYVQGLKTIYVSSETEALDILN 183

  Fly   212 KGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIGKLNLVDLAGSENVSKAGNEKG 276
            ||...|..|:|.|||||||||::|.:.| ::.:...||  .:.|:|.||||||||:|.|:| ..|
pombe   184 KGMGSRAVASTSMNAQSSRSHSIFVLEV-VQTDTESGE--TRRGRLFLVDLAGSESVGKSG-AVG 244

  Fly   277 IRVRETVNINQSLLTLGRVITALVD-RAPHVPYRESKLTRLLQESLGGRTKTSIIATISPGHKDI 340
            ..:.|...||:||.|||.||.:|.| :..|||||:|||||:|:|||||.::|::|...||...:.
pombe   245 QTLEEAKKINRSLSTLGMVINSLTDSKLSHVPYRDSKLTRILKESLGGNSRTTLIINCSPDSYNA 309

  Fly   341 EETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLKRDLMAAR--------------- 390
            .||||||.:.||||:|:||..||.:|:...:.::.....|.|.|.:..||
pombe   310 TETLSTLRFGHRAKSIKNKAVVNSELSVDEMKRQLYIYKDALSRCVCGARINNNLDYNNCHSNVW 374

  Fly   391 ------------DKNGIYLAEETYGEITLKLESQNRELNEKMLLLKALKDELQNKEKIFSEVSMS 443
                        :|:.:..||...|..|:: ||.|......:..:.....:..:..::::|..:.
pombe   375 SGEHSLTLSNLAEKSNLKEAEIIQGNRTIQ-ESNNDRDESTVASIHRHNFDSDSINRLYAEAQLE 438

  Fly   444 LVEKTQELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEKKELVASHMKTEQVLTTQAQEILAAAD 508
            |.::...|..|::.|.:     |:|  .|...:.||   .|||.:| :....||
pombe   439 LKQRDGVLSSTKQQLSD-----LMT--ALGDAQERY---VELVKNH-RVNSNLT----------- 481

  Fly   509 LATDDTHQLHG-TIERRRELDEKIRRSCDQFKDRMQDNLEMIGGSL-NLYQDQQAALKEQLSQEM 571
             |.:..:...| |||::   |:..  |.:..::.....|..:..|| .|...|:..:|..:|:|.
pombe   482 -ANNSLNDKPGFTIEQK---DKNF--SINNERNNFLQKLSTLDSSLAALVNVQRKLIKALISKER 540

  Fly   572 VNSSYVSQRL 581
            ..:..|.:::
pombe   541 PQNGTVIKKI 550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	147/348 (42%)
		SMC_prok_B	<408..728	CDD:274008	35/176 (20%)
		SMC_prok_B	<651..>921	CDD:274008
		Microtub_bind	923..>1004	CDD:464048
klp3	NP_594686.1	KISc_KHC_KIF5	1..325	CDD:276820	142/339 (42%)