DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp61F and klp3

DIOPT Version :9

Sequence 1:	NP_476818.1	Gene:	Klp61F / 38135	FlyBaseID:	FBgn0004378	Length:	1066	Species:	Drosophila melanogaster
Sequence 2:	NP_594686.1	Gene:	klp3 / 2542195	PomBaseID:	SPAC1834.07	Length:	554	Species:	Schizosaccharomyces pombe

Alignment Length:	595	Identity:	193/595 - (32%)
Similarity:	310/595 - (52%)	Gaps:	79/595 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 NIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHTLDSKLTKKFTFDRSFGPESKQCDVYSVV 83
            :|:|..|:||.|..|:.:...   :|:.|....|.|...|..:..|.|||.|.|.|.|.|::|..
pombe     3 SIKVVCRIRPTNQLEQDLGGN---NVIYPLNDSTVHIETSDYSGNFVFDRVFHPSSTQNDIFSYS 64

  Fly    84 VSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGIIPRALSHLFDELR-- 146
            :...::::..|||.||.||||||:|||:||:|     :::::|.:   |:.||.|..:||::|
pombe    65 IESTVDDLFLGYNGTVLAYGQTGSGKTYTMMG-----IENNFEKE---GMTPRMLRRIFDKIRDS 121

  Fly   147 MMEVEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGSVIIQGLEEIPVHSKDDVYKLLE 211
            ....||.:::||:|:|.|::.|||| :...::.:.:|  |...|.:|||:.|.|.|:.:...:|.
pombe   122 PSTTEYEVKVSYMEIYMEKIHDLLS-EKNDRLTVHED--KLQGVYVQGLKTIYVSSETEALDILN 183

  Fly   212 KGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIGKLNLVDLAGSENVSKAGNEKG 276
            ||...|..|:|.|||||||||::|.:.| ::.:...||  .:.|:|.||||||||:|.|:| ..|
pombe   184 KGMGSRAVASTSMNAQSSRSHSIFVLEV-VQTDTESGE--TRRGRLFLVDLAGSESVGKSG-AVG 244

  Fly   277 IRVRETVNINQSLLTLGRVITALVD-RAPHVPYRESKLTRLLQESLGGRTKTSIIATISPGHKDI 340
            ..:.|...||:||.|||.||.:|.| :..|||||:|||||:|:|||||.::|::|...||...:.
pombe   245 QTLEEAKKINRSLSTLGMVINSLTDSKLSHVPYRDSKLTRILKESLGGNSRTTLIINCSPDSYNA 309

  Fly   341 EETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLKRDLMAAR--------------- 390
            .||||||.:.||||:|:||..||.:|:...:.::.....|.|.|.:..||
pombe   310 TETLSTLRFGHRAKSIKNKAVVNSELSVDEMKRQLYIYKDALSRCVCGARINNNLDYNNCHSNVW 374

  Fly   391 ------------DKNGIYLAEETYGEITLKLESQNRELNEKMLLLKALKDELQNKEKIFSEVSMS 443
                        :|:.:..||...|..|:: ||.|......:..:.....:..:..::::|..:.
pombe   375 SGEHSLTLSNLAEKSNLKEAEIIQGNRTIQ-ESNNDRDESTVASIHRHNFDSDSINRLYAEAQLE 438

  Fly   444 LVEKTQELKKTEENLLNTKGTLLLTKKVLTKTKRRYKEKKELVASHMKTEQVLTTQAQEILAAAD 508
            |.::...|..|::.|.:     |:|  .|...:.||   .|||.:| :....||
pombe   439 LKQRDGVLSSTKQQLSD-----LMT--ALGDAQERY---VELVKNH-RVNSNLT----------- 481

  Fly   509 LATDDTHQLHG-TIERRRELDEKIRRSCDQFKDRMQDNLEMIGGSL-NLYQDQQAALKEQLSQEM 571
             |.:..:...| |||::   |:..  |.:..::.....|..:..|| .|...|:..:|..:|:|.
pombe   482 -ANNSLNDKPGFTIEQK---DKNF--SINNERNNFLQKLSTLDSSLAALVNVQRKLIKALISKER 540

  Fly   572 VNSSYVSQRL 581
            ..:..|.:::
pombe   541 PQNGTVIKKI 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	147/348 (42%)
		Kinesin	25..356	CDD:278646	140/333 (42%)
		Microtub_bind	923..>1009	CDD:290642
klp3	NP_594686.1	KIP1	1..546	CDD:227392	192/589 (33%)
klp3	NP_594686.1	KISc_KHC_KIF5	1..325	CDD:276820	142/339 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910