Protein Alignment Klp61F and KIF1B

DIOPT Version :10

• Sequence 1: NP_476818.1
• Gene: Klp61F / 38135
• FlyBaseID: FBgn0004378
• Length: 1066
• Species: Drosophila melanogaster
• Sequence 2: NP_001352880.1
• Gene: KIF1B / 23095
• HGNCID: 16636
• Length: 1816
• Species: Homo sapiens
• Alignment Length: 1054
• Identity: 257/1054 - (24%)
• Similarity: 447/1054 - (42%)
• Gaps: 266/1054 - (25%)

  Fly    16 SNQNIQVYVRVRPLNSRE-----RCI-----RSAEVVDVVGPREVVTRHTLDSKLTKKFTFDRSF 70
            |..:::|.|||||.||||     :||     .|..:::...|:|.          .|.|:||.|:
Human     2 SGASVKVAVRVRPFNSRETSKESKCIIQMQGNSTSIINPKNPKEA----------PKSFSFDYSY 56

  Fly    71 ----GPE----SKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWED 127
                .||    :.|..||:.:...::.....|||..:|||||||.||::||:|.         ::
Human    57 WSHTSPEDPCFASQNRVYNDIGKEMLLHAFEGYNVCIFAYGQTGAGKSYTMMGK---------QE 112

  Fly   128 DSDIGIIPRALSHLFDELR---MMEVEYTMRISYLELYNEELCDLLSTDDTTKIRIFDDSTKKGS 189
            :|..||||:....||:::.   ..|:.|::.:||:|:|.|.:.|||:..:...:|:.:....  .
Human   113 ESQAGIIPQLCEELFEKINDNCNEEMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLL--G 175

  Fly   190 VIIQGLEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVV----HIRENGIEGED 250
            ..::.|.::.|.|..|:..|::.|.:.|..|.|.||..|||||.||:||.    |..|..:..|
Human   176 PYVEDLSKLAVTSYTDIADLMDAGNKARTVAATNMNETSSRSHAVFTIVFTQKKHDNETNLSTE- 239

  Fly   251 MLKIGKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVD------------RA 303
              |:.|::||||||||.....| .||.|::|..|||:||.|||:||:||.:            :.
Human   240 --KVSKISLVDLAGSERADSTG-AKGTRLKEGANINKSLTTLGKVISALAEVDNCTSKSKKKKKT 301

  Fly   304 PHVPYRESKLTRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTK 368
            ..:|||:|.||.||:|:|||.::|:::|.:||...:.:||||||.||.|||.|:....:|:....
Human   302 DFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIKCNAVINEDPNA 366

  Fly   369 KTVLKEYTEEIDKLKRDLMAARDKNGIY----LAEETYGEITLKLESQNRELNEKMLLLKALKDE 429
            |.| :|..||:.:|| ||:.|:....|.    |.::..|..:                 |.|||.
Human   367 KLV-RELKEEVTRLK-DLLRAQGLGDIIDIDPLIDDYSGSGS-----------------KYLKDF 412

  Fly   430 LQNKEKI-----------FSEVSMSLVEKT------------QELKKTEENLLNTKG------TL 465
            ..||.:.           ||..||..:..:            ..:...:|.:::|.|      .|
Human   413 QNNKHRYLLASENQRPGHFSTASMGSLTSSPSSCSLSSQVGLTSVTSIQERIMSTPGGEEAIERL 477

  Fly   466 LLTKKVLTKTKRRYKEKKELVASHMKTEQVLTTQAQEILAAADLATDDTHQLHGTIERRRE---- 526
            ..::|::.:....::||       ::..:.:..:.:.:||...:|..:.....|....::.
Human   478 KESEKIIAELNETWEEK-------LRKTEAIRMEREALLAEMGVAIREDGGTLGVFSPKKTPHLV 535

  Fly   527 ---------------LDEKIRRSCDQFKDRMQDNLEMIGGSLN----LYQDQQAALKE------- 565
                           :.:.|.|......:|.|| :.:.|..:.    :::.:::...|
Human   536 NLNEDPLMSECLLYYIKDGITRVGQADAERRQD-IVLSGAHIKEEHCIFRSERSNSGEVIVTLEP 599

  Fly   566 -QLSQEMVNSSYVSQRLALNSSKSIEMLKEMCAQ-SLQDQTNLHNKLIGEVMKISDQHSQAFVAK 628
             :.|:..||...|||.:.|.|...|.|.|....: :..:|.....:........|:.....|..:
Human   600 CERSETYVNGKRVSQPVQLRSGNRIIMGKNHVFRFNHPEQARAEREKTPSAETPSEPVDWTFAQR 664

  Fly   629 LMEQMQQQQLLMSKEIQTNLQVIEENNQRHKAMLDSMQEKFATIIDSSLQSVEEHAKQMHKKLEQ 693
              |.:::|.:.|.:|::..||.:|...::.|...|.:.|:.....:|.||:::   ||:..:  .
Human   665 --ELLEKQGIDMKQEMEKRLQEMEILYKKEKEEADLLLEQQRLDYESKLQALQ---KQVETR--S 722

  Fly   694 LGAMSLPDAEELQNLQEEL---ANERALAQQEDALLESMMMQMEQIKNLRSKNSI------SMSV 749
            |.|.:..:.||    :||:   .:|..|||.  |..:....|...:::|...|::      ::||
Human   723 LAAETTEEEEE----EEEVPWTQHEFELAQW--AFRKWKSHQFTSLRDLLWGNAVYLKEANAISV 781

  Fly   750 HLNKMEE--------------------SRLTRNH------------RIDDIKSGIQDY------- 775
            .|.|..:                    :.:.:.|            .:.|:|:|...|
Human   782 ELKKKVQFQFVLLTDTLYSPLPPELLPTEMEKTHEDRPFPRTVVAVEVQDLKNGATHYWSLEKLK 846

  Fly   776 QKLGI---------EASQSAQAELTSQMEAGMLCLDQGVANCSMLQVHMKNLNQKYEKETNENVG 831
            |:|.:         |.:.|||.|..:.:.......|         :.|...|           ||
Human   847 QRLDLMREMYDRAGEMASSAQDESETTVTGSDPFYD---------RFHWFKL-----------VG 891

  Fly   832 SVRVHHNQVEIICQESKQQLEAVQEKT--------EVNLEQMVDARQQLITE-DRQRFIGHATVA 887
            |..:.|..|.          |.:.::|        :.::.::.|.:|..:.: |.:.|:..|  .
Human   892 SSPIFHGCVN----------ERLADRTPSPTFSTADSDITELADEQQDEMEDFDDEAFVDDA--G 944

  Fly   888 TDL-VQESNRQFSE 900
            :|. .:|.:..||:
Human   945 SDAGTEEGSDLFSD 958

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	137/384 (36%)
		SMC_prok_B	<408..728	CDD:274008	68/383 (18%)
		SMC_prok_B	<651..>921	CDD:274008	58/317 (18%)
		Microtub_bind	923..>1004	CDD:464048
KIF1B	NP_001352880.1	KISc_KIF1A_KIF1B	4..361	CDD:276816	136/381 (36%)
		Interaction with KIFBP. /evidence=ECO:0000269|PubMed:16225668	270..350		36/79 (46%)
		Kinesin_assoc	358..555	CDD:465047	35/222 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	431..450		4/18 (22%)
		FHA_KIF1B	530..639	CDD:438779	18/109 (17%)
		GimC	662..>719	CDD:440992	15/61 (25%)
		KIF1B	845..892	CDD:463574	11/66 (17%)
		KIF1B	<956..975	CDD:463574	2/3 (67%)
		DUF3694	1266..1413	CDD:463599
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1550..1570
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1617..1660
		PH_KIFIA_KIFIB	1697..1799	CDD:269939