DRSC/TRiP Functional Genomics Resources

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Protein Alignment Klp61F and KIF21B

DIOPT Version :10

Sequence 1:NP_476818.1 Gene:Klp61F / 38135 FlyBaseID:FBgn0004378 Length:1066 Species:Drosophila melanogaster
Sequence 2:NP_001239029.1 Gene:KIF21B / 23046 HGNCID:29442 Length:1637 Species:Homo sapiens


Alignment Length:1278 Identity:324/1278 - (25%)
Similarity:540/1278 - (42%) Gaps:300/1278 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 IQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHTLDSKLTKKFTFDRSFGPESKQCDVYSVVV 84
            ::|.||:||..|:|: |....:...|.|.|.......|    |.||:|..|..::.|..:||..|
Human     9 VKVAVRIRPQLSKEK-IEGCHICTSVTPGEPQVLLGKD----KAFTYDFVFDLDTWQEQIYSTCV 68

  Fly    85 SPLIEEVLNGYNCTVFAYGQTGTGKTHTM-VGNETAELKSSWEDDSDIGIIPRALSHLF------ 142
            |.|||....|||.||.||||||.|||:|| .|.:.|      ..:.:.||||||::|||      
Human    69 SKLIEGCFEGYNATVLAYGQTGAGKTYTMGTGFDMA------TSEEEQGIIPRAIAHLFGGIAER 127

  Fly   143 ----DELRMMEVEYTMRISYLELYNEELCDLL-STDD------TTKIRIFDDSTKKGSVIIQGLE 196
                .|..:...|:.:...:|||||||:.||. ||.|      .:.|:|.:|:  .|.:...|:.
Human   128 KRRAQEQGVAGPEFKVSAQFLELYNEEILDLFDSTRDPDTRHRRSNIKIHEDA--NGGIYTTGVT 190

  Fly   197 EIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSI------------VVHIRENGI--- 246
            ...:||::::.:.|::|...|.||:|.||.||||||.:|:|            :|:....|:   
Human   191 SRLIHSQEELIQCLKQGALSRTTASTQMNVQSSRSHAIFTIHLCQMRMCTQPDLVNEAVTGLPDG 255

  Fly   247 ---EGEDMLKIGKLNLVDLAGSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVDRAP---H 305
               ..|......|.:.|||||||.:.:.| ..|.|.:|.::||..||.||.||:||.|::.   |
Human   256 TPPSSEYETLTAKFHFVDLAGSERLKRTG-ATGERAKEGISINCGLLALGNVISALGDQSKKVVH 319

  Fly   306 VPYRESKLTRLLQESLGGRTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKT 370
            ||||:||||||||:||||.::|.:||.:||..:|..|||:||:||:||:||:||..|||..|.:.
Human   320 VPYRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRARNIKNKVVVNQDKTSQQ 384

  Fly   371 VLKEYTEEIDKLKRDLMAARDKNGIYLAE---ETYGEI---TLKLESQNRELNEKMLLLKALKDE 429
            : .....||.:|:.:||..:....: :.|   |.|.::   ...|:.:|..|..::..::...|.
Human   385 I-SALRAEIARLQMELMEYKAGKRV-IGEDGAEGYSDLFRENAMLQKENGALRLRVKAMQEAIDA 447

  Fly   430 LQNK-EKIFSEVSMSLVEKTQE------------LKKTEENLLNTKGTLLLTKKVLTKTKRRYKE 481
            :.|: .::.|:.:..|:.|..:            :::.||  |.||   ||..:.:.::.||...
Human   448 INNRVTQLMSQEANLLLAKAGDGNEAIGALIQNYIREIEE--LRTK---LLESEAMNESLRRSLS 507

  Fly   482 KKEL------------------VASHMKTEQVLTTQAQEILAAADLATDDTHQL-HGTIERRREL 527
            :...                  .||.|:       .|.|::..   |..|..:| ...:.:||:.
Human   508 RASARSPYSLGASPAAPAFGGSPASSME-------DASEVIRR---AKQDLERLKKKEVRQRRKS 562

  Fly   528 DEKIRRSCDQFKDR---MQDNLEMIGGSLNLYQDQ---QAALKEQLSQEMVNSSYVSQRLALNSS 586
            .||     :.||.|   .|:|.|....:....:::   ::..:|:..:|..:....|:...::|.
Human   563 PEK-----EAFKKRAKLQQENSEETDENEAEEEEEERDESGCEEEEGREDEDEDSGSEESLVDSD 622

  Fly   587 KSIEMLKEMCAQS-LQDQT---NLHNKLIGEVMKISDQHSQAFVAKLMEQMQQQQLLMSKEIQTN 647
            ...|. ||:..|: |.|.|   .:..|||.|:     ::||..:..|..|.:::.:|:..:|: :
Human   623 SDPEE-KEVNFQADLADLTCEIEIKQKLIDEL-----ENSQRRLQTLKHQYEEKLILLQNKIR-D 680

  Fly   648 LQVIEENNQRHKAMLDSMQEKFATIIDSSLQSVEEHAKQMHKKLEQLGAMSLPDA---------- 702
            .|:..:...::.:.::...|:.|..|.:   ..|:..::|::.|::|.|.....|          
Human   681 TQLERDRVLQNLSTMECYTEEKANKIKA---DYEKRLREMNRDLQKLQAAQKEHARLLKNQSRYE 742

  Fly   703 EELQNLQEELA--------------------------NERALAQ-------QEDAL--LESMMMQ 732
            .||:.||.|:|                          ..|.:||       ||..:  |||...|
Human   743 RELKKLQAEVAEMKKAKVALMKQMREEQQRRRLVETKRNREIAQLKKEQRRQEFQIRALESQKRQ 807

  Fly   733 MEQIKNLRSKN--------------------------------SISMSVHLNKMEE-----SRLT 760
            .|.:  ||.|.                                .:|.|...::.|.     |.:.
Human   808 QEMV--LRRKTQEVSALRRLAKPMSERVAGRAGLKPPMLDSGAEVSASTTSSEAESGARSVSSIV 870

  Fly   761 R------NHRIDD--------IKSGIQDYQKLGIEASQSAQAELTSQ------------------ 793
            |      ||.:.|        .:...:.:||.|...|.|..|.|..|                  
Human   871 RQWNRKINHFLGDHPAPTVNGTRPARKKFQKKGASQSFSKAARLKWQSLERRIIDIVMQRMTIVN 935

  Fly   794 MEAGMLCLDQGVANCSMLQVHMKNLNQKYEKETNENVGSVRVHHNQVEII-------------CQ 845
            :||.|..|.:......:||..::...::.:.|:.|....::....::|::             ||
Human   936 LEADMERLIKKREELFLLQEALRRKRERLQAESPEEEKGLQELAEEIEVLAANIDYINDGITDCQ 1000

  Fly   846 ESKQQLEAVQEKTEVN---------------------LEQMVDARQQLITEDRQ-RFIGHATVAT 888
            .:..|||..:|:.:..                     |:..:|...|:..::.| |.:......|
Human  1001 ATIVQLEETKEELDSTDTSVVISSCSLAEARLLLDNFLKASIDKGLQVAQKEAQIRLLEGRLRQT 1065

  Fly   889 DLVQESNRQFSEHAEHQRQQLQICEQELVRFQQSELKTYAPTG---TTPSKRDFVYPRTLVATSP 950
            |:...|.......|..::.:.....|.|:...|.| ..||.|.   :..|:..|....|:..::.
Human  1066 DMAGSSQNHLLLDALREKAEAHPELQALIYNVQQE-NGYASTDEEISEFSEGSFSQSFTMKGSTS 1129

  Fly   951 HQEIVRRYRQELDWSDLDTTATIDECSEGEHDVSMHSVQELSETETIMNSTPIEPVDGV--TVKR 1013
            |.:.  :::.|...| ....|...||.....|:|..::     |:::.:...|:. |||  :|:.
Human  1130 HDDF--KFKSEPKLS-AQMKAVSAECLGPPLDISTKNI-----TKSLASLVEIKE-DGVGFSVRD 1185

  Fly  1014 GCGTTRNSNSNALKPPVATGGKRSSSLSRS-LTPSKTSPRGSP 1055
            .....|.|.:.:|....:|..::|.:...| ||..|:..||.|
Human  1186 PYYRDRVSRTVSLPTRGSTFPRQSRATETSPLTRRKSYDRGQP 1228

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Klp61FNP_476818.1 KISc_BimC_Eg5 17..365 CDD:276815 153/383 (40%)
SMC_prok_B <408..728 CDD:274008 78/406 (19%)
SMC_prok_B <651..>921 CDD:274008 70/418 (17%)
Microtub_bind 923..>1004 CDD:464048 16/83 (19%)
KIF21BNP_001239029.1 KISc_KIF4 7..371 CDD:276823 148/375 (39%)
CwlO1 379..>539 CDD:443091 30/173 (17%)
Interaction with TRIM3. /evidence=ECO:0000250|UniProtKB:Q9QXL1 400..1099 131/731 (18%)
Smc <472..>1064 CDD:440809 113/623 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 509..538 3/35 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 552..628 15/81 (19%)
EnvC 633..>842 CDD:443969 43/219 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 830..865 3/34 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 880..906 4/25 (16%)
Rcc_KIF21B 929..1010 CDD:410203 14/80 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1194..1251 10/35 (29%)
WD40 1305..1613 CDD:238121
WD 1 1306..1343
WD40 repeat 1312..1346 CDD:293791
WD 2 1346..1384
WD40 repeat 1351..1387 CDD:293791
WD40 repeat 1407..1450 CDD:293791
WD 3 1410..1448
WD 4 1451..1493
WD40 repeat 1456..1500 CDD:293791
WD 5 1502..1539
WD40 repeat 1509..1541 CDD:293791
WD 6 1543..1582
WD40 repeat 1548..1572 CDD:293791
WD 7 1585..1622
Blue background indicates that the domain is not in the aligned region.

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