DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp61F and kif11

DIOPT Version :9

Sequence 1:	NP_476818.1	Gene:	Klp61F / 38135	FlyBaseID:	FBgn0004378	Length:	1066	Species:	Drosophila melanogaster
Sequence 2:	NP_775368.2	Gene:	kif11 / 195818	ZFINID:	ZDB-GENE-020426-1	Length:	1062	Species:	Danio rerio

Alignment Length:	1125	Identity:	393/1125 - (34%)
Similarity:	597/1125 - (53%)	Gaps:	154/1125 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TSRQPQKKSNQ---NIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHT---LDSKLTKKFTF 66
            :|:.|..|.::   ||||.||.||.|:.||...|..||:....|:.|...|   .|....|.:||
Zfish     3 SSQVPAAKKDEKGRNIQVVVRCRPFNTVERKSGSHTVVECDQNRKEVIMRTGGATDKAARKTYTF 67

  Fly    67 DRSFGPESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDI 131
            |..|||.:||.:||..||.|:::||:.|||||:|||||||||||.||.|:.:...:.:||:|...
Zfish    68 DMVFGPSAKQIEVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGDRSPNEEFTWEEDPLA 132

  Fly   132 GIIPRALSHLFDELRMMEVEYTMRISYLELYNEELCDLLS--TDDTTKIRIFDDSTKKGSVIIQG 194
            |||||.|..:|::|.....|:::::|.||:|||||.||||  .|.|.::::|||...|..|.|:|
Zfish   133 GIIPRTLHQIFEKLSNNGTEFSVKVSLLEIYNEELFDLLSPAPDVTERLQLFDDPRNKRGVTIKG 197

  Fly   195 LEEIPVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIGKLNL 259
            ||||.||:|::||::||:|..:||||:|||||.|||||:|||:.:|::|..::||:::|||||||
Zfish   198 LEEITVHNKNEVYQILERGAAKRKTASTLMNAYSSRSHSVFSVTIHMKEITLDGEELVKIGKLNL 262

  Fly   260 VDLAGSENVSKAGN-EKGIRVRETVNINQSLLTLGRVITALVDRAPHVPYRESKLTRLLQESLGG 323
            ||||||||:.::|. :|  |.||..|||||||||||||.|||:|.||||||||||||:||:||||
Zfish   263 VDLAGSENIGRSGAVDK--RAREAGNINQSLLTLGRVIKALVERGPHVPYRESKLTRILQDSLGG 325

  Fly   324 RTKTSIIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLKRDLMA 388
            |||||||||:||...::|||||||:||:|||:|.|||||||||||:|::|||||||::|||||.|
Zfish   326 RTKTSIIATVSPASINLEETLSTLDYANRAKSIMNKPEVNQKLTKRTLIKEYTEEIERLKRDLAA 390

  Fly   389 ARDKNGIYLAEETYGEITLKLESQNRELNEKMLLLKALKDELQNKEKIFSEVSMSLVEKTQELKK 453
            .|||:|:||:.:.|..:..|:.||..::.|....:.|:::||:....:|::....|.:.|::|:.
Zfish   391 TRDKHGVYLSVDNYETLNGKIVSQEEQITEYTERIAAMEEELKKIIDLFTDSKQKLEQCTEDLQD 455

  Fly   454 TEENLLNTKGTLLLTKKVLTKTKRRYKEKKELVASHMKT-EQVLTTQAQEILAAADLATDDTHQL 517
            ..:.|..       ..|.|::|:.|..: :|.:::.::| |..|...|.::|:.|:.:|.|...|
Zfish   456 KNQRLEE-------AHKDLSETRHRLNQ-EEFISTQLQTNESHLYNTADQLLSTAEASTQDVGGL 512

  Fly   518 HGTIERRRELD---EKIRRSCDQFKDRMQDNLEMIGGSLNLYQDQQAALKEQLSQEMVNSSY--- 576
            |..::|:::::   .|::.|..|..:             |.|...|.:||||..:......|
Zfish   513 HAKLQRKKDVELHNSKVQESFSQCME-------------NCYNSMQTSLKEQSQKHAAMIDYYRS 564

  Fly   577 -VSQRLALNSSKSIEMLK-----------------EMCAQSLQDQTNLHNKLIGEVMKISDQHSQ 623
             |.:.|..|.....|.|.                 |.|.:.:.:|..|.......:::|.|:|.|
Zfish   565 SVGELLNTNGKVFKETLSAVCESYSSIKGAVGEGVERCKEQVLNQEKLSQDAQNSILEILDEHKQ 629

  Fly   624 AFVAKLMEQMQ---QQQLLMSKEIQTNLQV---IEENNQRHKA----MLDSMQEKFATIIDSSLQ 678
            .....|:.|..   :..:.|:..::..|..   :.|..|..||    ..|:..|..|::.:.:||
Zfish   630 HLEEVLVAQAVPGIRSVMSMNDNLKQTLHKYHNLAEQMQGVKADMMTFFDAYTESLASMRECALQ 694

  Fly   679 SVE----EHAKQMHKKLEQLG-AMSLPDAEELQNLQEELANERALAQQED--ALLESMMMQMEQI 736
            ...    ||.| :.:::.|.| :..:..||.:|.||.:: |..|:..|.|  .|.::...|:..:
Zfish   695 GFNTLRAEHDK-LKQQISQAGNSHQVRVAELVQCLQNQM-NLLAVDTQNDFEGLSQAASAQIPPL 757

  Fly   737 KNLRSKNSISMSVHLNKMEESRLTRNHRIDDIKSGIQDYQKLGIEASQSAQAELTSQMEAGMLCL 801
            :.|:|    |:.......||..::...|:.....|:              .:|:.|..:.|...|
Zfish   758 ETLQS----SIESKCTVAEEQAVSVRARLGSSVHGV--------------ISEMNSVTKEGERAL 804

  Fly   802 DQGVANCSMLQVHMKNLNQKYEKETNENVGSVRVH-HNQVEIICQES---KQQLEAVQEKTEVNL 862
            ::....|..||..:.:|.:...|..:|..|..... ..|:::|.|..   :..|::|:||.| ..
Zfish   805 EECAGYCGHLQTSLDSLAESGLKWCDEAKGLTESKAQEQLKLIRQTDTAVQDLLKSVEEKGE-KA 868

  Fly   863 EQMVDARQQLITEDRQRFIGHATVATDLVQESNRQFSEHAEHQRQQLQICEQEL---VRFQQSEL 924
            .|..:||...:.::.:..:|...:.|. ..|:..|     ||:.....|..|.|   ..|..|||
Zfish   869 VQDCEARLGQMQQEMEATLGRVEMQTS-KDEATLQ-----EHRETLSSINTQALDTVHNFISSEL 927

  Fly   925 KTYAPTGTTPSKRDFVYPRTLVATSPHQEIVRRYR--QELDWSDLDTTATIDECSEG-------- 979
            :...||||||.:::::|||.|......:|:...:|  ||...|:|.....:.|..|.
Zfish   928 RQDLPTGTTPQRKEYMYPRVLSRPRSREELEEEFRAQQEQLQSELKPCEIVMEVEEEKPVDQDSL 992

  Fly   980 EHDVSMHSVQELSETETIMNSTPIEPVDGVTVKRGCGTTRNSNSNAL-----KPPVATGGKRSSS 1039
            |.|||:.|                   ||...::.|     |:.|.:     :.|......:..:
Zfish   993 EDDVSVSS-------------------DGNNTEQSC-----SDENLICYENGRIPFFKKKSKKEN 1033

  Fly  1040 LSRSLTPSK-------TSPR 1052
            .|:||..||       |.||
Zfish  1034 GSKSLNRSKVENDSMSTPPR 1053

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	204/356 (57%)
		Kinesin	25..356	CDD:278646	192/336 (57%)
		Microtub_bind	923..>1009	CDD:290642	26/95 (27%)
kif11	NP_775368.2	KISc_BimC_Eg5	15..367	CDD:276815	204/353 (58%)
		KISc	17..365	CDD:214526	202/349 (58%)
		Microtub_bind	926..1061	CDD:290642	39/152 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594331
Domainoid	1	1.000	368	1.000	Domainoid score	I866
eggNOG	1	0.900	-	-		E2759_KOG0243
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3322
Inparanoid	1	1.050	544	1.000	Inparanoid score	I1130
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111985at33208
OrthoFinder	1	1.000	-	-		FOG0002556
OrthoInspector	1	1.000	-	-		oto40859
orthoMCL	1	0.900	-	-		OOG6_102884
Panther	1	1.100	-	-	LDO	PTHR47970
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4221
SonicParanoid	1	1.000	-	-		X1681
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.790