DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Klp61F and bmk-1

DIOPT Version :9

Sequence 1:	NP_476818.1	Gene:	Klp61F / 38135	FlyBaseID:	FBgn0004378	Length:	1066	Species:	Drosophila melanogaster
Sequence 2:	NP_001379525.1	Gene:	bmk-1 / 179948	WormBaseID:	WBGene00000257	Length:	963	Species:	Caenorhabditis elegans

Alignment Length:	1023	Identity:	331/1023 - (32%)
Similarity:	524/1023 - (51%)	Gaps:	142/1023 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SRQPQKKSNQNIQVYVRVRPLNSRERCIRSAEVVDVVGPREVVTRHTLDSKLTKKF-TFDRSFGP 72
            ||:...:...|::|.||:||:|..||..:...||.|...::.:      ....|.| .|.|::.|
Worm     8 SRKKHSEPTSNLRVAVRIRPMNGTERSEKCTNVVKVDKGKQAI------ELKGKSFGPFFRTYDP 66

  Fly    73 ESKQCDVYSVVVSPLIEEVLNGYNCTVFAYGQTGTGKTHTMVGNETAELKSSWEDDSDIGIIPRA 137
            ::.|.::||.:||..|::|:.|:|||||||||||||||.||.|..| :.||| .||...||||||
Worm    67 DTTQEEIYSDLVSSQIKKVIAGFNCTVFAYGQTGTGKTFTMEGGRT-DAKSS-TDDPTTGIIPRA 129

  Fly   138 LSHLFDEL-RMMEVEYTMRISYLELYNEELCDLL-STD--DTTKIRIFDDSTKKGSVIIQGLEEI 198
            :..:|::| |....||::|:||:|||||||.||| |||  |..::|||||..||| ||:.|:||:
Worm   130 VEDIFEQLERCGCEEYSLRVSYIELYNEELFDLLASTDNEDRERLRIFDDPNKKG-VIVSGVEEV 193

  Fly   199 PVHSKDDVYKLLEKGKERRKTATTLMNAQSSRSHTVFSIVVHIRENGIEGEDMLKIGKLNLVDLA 263
            ||.::.||:|||:.|.|:|:||.||||..|||||::|.:.|.||||...||:::|.|||||||||
Worm   194 PVRNRSDVFKLLQLGAEKRRTAATLMNMHSSRSHSLFMVNVVIRENTTTGEELVKQGKLNLVDLA 258

  Fly   264 GSENVSKAGNEKGIRVRETVNINQSLLTLGRVITALVDRAPHVPYRESKLTRLLQESLGGRTKTS 328
            ||||:.::| .:|.|.:|..:||||||||||||..|.....|:||||||||||||:||||.|.||
Worm   259 GSENIGRSG-AQGNRAKEAGSINQSLLTLGRVIRLLTTNGQHIPYRESKLTRLLQDSLGGSTITS 322

  Fly   329 IIATISPGHKDIEETLSTLEYAHRAKNIQNKPEVNQKLTKKTVLKEYTEEIDKLKRDLMAARDKN 393
            :|||:||...:.||:.||||||.||.||:|||..|.||:|||:||||::||:||:|||.|||:||
Worm   323 LIATLSPSSSNFEESQSTLEYAMRAANIKNKPVCNTKLSKKTILKEYSDEIEKLRRDLRAAREKN 387

  Fly   394 GIYLAEETYGEITLKLESQNRELNEKMLLLKALKDELQNKEKIFSEVSMSLVEKTQEL----KKT 454
            |:.:::|::.|.        ::.:||:..|:...|...::.:||:|..|.:.|:.::|    .:.
Worm   388 GVIISQESHDEF--------QKNSEKVQELEQHLDNAVDRLRIFTEDQMHMDEQYRQLYERKGEL 444

  Fly   455 EENLLNTKGTLLLTKKVLTKTKRRYKEKKELV----ASHMKTEQVLTTQAQEILAAADLATDDTH 515
            |:.|.:....:.:.:|.|..|.....:..|::    .|.:|....|||..    .|||....|..
Worm   445 EDRLRDRIREMAVKEKELADTNDVLNKHIEVIGLMHTSALKAFDQLTTSQ----GAADEMQTDLR 505

  Fly   516 QLHGTIERRRELDEKIRRSCDQFKDRMQDNLEMIGGSLNLYQDQQAALKEQLSQEM---VNSSYV 577
            .....::.....|::.:...|.|..:|.|.::......|..:.....|.::||:.:   |.|...
Worm   506 AFWRKVDEMERADDRNKIVIDHFSKKMSDFIDTTSKLTNSLKADGDLLSKKLSENICPHVKSMES 570

  Fly   578 SQR----------------LALNSSKSIEMLKEMCAQSLQDQTNLHNKLIGEVMKISDQHSQAFV 626
            :.|                :..:|....:::..|.|.|::::..|..     |||..|...:::.
Worm   571 AHRDIESTAMDMETHAICIMKKSSEAEKKVIDNMTAISMENRIRLET-----VMKTCDDFYKSYS 630

  Fly   627 AKLMEQMQQQQLLMSKEIQTNLQVIEENNQRHKAMLDSMQEKFATIIDSSLQSVEEHAKQMHKKL 691
            ||..|   ..|:::.|        ::|..::.....:.|:...:|:..::..|.|....:..|.:
Worm   631 AKSQE---FTQMVVDK--------LDEVKKQVSDFTEDMKPLVSTLHQTTCDSYEARTNESKKNV 684

  Fly   692 EQLGA--MSLPDAEELQNLQEELANERALAQQEDALLESMMMQMEQIKNLRSKNSISMSVHLNKM 754
            |.:.|  .|:.|:.:...||.|..:.:.....|..::.....|...:..|.:..::..|:..|.:
Worm   685 EHVRAACSSMADSMKALMLQVEQLSTKVAENHEKQVIADQNNQETILDTLNTAETVVQSLEDNIV 749

  Fly   755 EESRLTRNHRIDDIKSGIQDYQKLGIEASQSAQAELTSQMEAGMLCLDQGVANCSMLQVHMKNLN 819
            |..         |:|..:.|.:|. ::.:.:.|                        :.|::...
Worm   750 ETC---------DVKQEMDDTKKT-LKQTDAKQ------------------------ENHIQVEK 780

  Fly   820 QKYEKETNENVGSVRVHHNQVEIICQES-------KQQLEAVQEKTEVNLEQMVDARQQLITEDR 877
            ::.|::.||...:::...::.|....|:       |.:..|..||.:|..|.:.|..:: .|::.
Worm   781 ERAEEKENEVKVALKSFSDEAEATRGEAREFSNTLKSRFSATSEKCKVTGELVSDCTKK-ATDEL 844

  Fly   878 QRFIGHATVATDLV-QES----NRQFSEHAE-----HQR---------QQLQICEQELV------ 917
            ...:...|.:|.:| :||    |.....|.:     .||         :..|..|.|::
Worm   845 SSLLDEFTKSTIVVTKESAAVVNSVVLVHVDPSVNVPQRILPSFPLVSELNQPVEPEVLLGFGEG 909

  Fly   918 --RFQQSELKTYAPTGTTPSKRDFVYPRTLVATSPHQEIVRRYRQELD 963
              .|...||.|.....|:..:||.:...|....|| ..|::|..|.::
Worm   910 NDDFDTDELATKKRRVTSFVRRDSLLETTNNFLSP-SSIIKRREQAIE 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Klp61F	NP_476818.1	KISc_BimC_Eg5	17..365	CDD:276815	191/352 (54%)
		Kinesin	25..356	CDD:278646	182/335 (54%)
		Microtub_bind	923..>1009	CDD:290642	12/41 (29%)
bmk-1	NP_001379525.1	Motor_domain	17..359	CDD:419868	191/351 (54%)
bmk-1	NP_001379525.1	CCDC158	<365..>839	CDD:318193	107/535 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166037
Domainoid	1	1.000	322	1.000	Domainoid score	I652
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	425	1.000	Inparanoid score	I978
Isobase	1	0.950	-	0	Normalized mean entropy	S2292
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D111985at33208
OrthoFinder	1	1.000	-	-		FOG0002556
OrthoInspector	1	1.000	-	-		oto19363
orthoMCL	1	0.900	-	-		OOG6_102884
Panther	1	1.100	-	-	LDO	PTHR47970
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4221
SonicParanoid	1	1.000	-	-		X1681
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.880